Publications by authors named "Hannah Crothers"
Article Synopsis
- Primary sclerosing cholangitis (PSC) is a significant concern in Europe as it is linked to liver transplants and cancer risk in people with inflammatory bowel disease (IBD); this study aims to examine the trends in prevalence and forecast future changes in PSC and IBD among adults in England.
- Data was analyzed from a national healthcare registry to determine the prevalence rates of PSC with IBD from 2015 to 2020, and predictions were made for 2021-2027 based on current trends and survival rates.
- The findings indicate that the prevalence of PSC associated with IBD is expected to grow faster than that of IBD alone, highlighting the need for further
UK-Wide Multicenter Evaluation of Second-line Therapies in Primary Biliary Cholangitis.
Clin Gastroenterol Hepatol
June 2023
Background & Aims: Thirty-to-forty percent of patients with primary biliary cholangitis inadequately respond to ursodeoxycholic acid. Our aim was to assemble national, real-world data on the effectiveness of obeticholic acid (OCA) as a second-line treatment, alongside non-licensed therapy with fibric acid derivatives (bezafibrate or fenofibrate).
Methods: This was a nationwide observational cohort study conducted from August 2017 until June 2021.
Objective: Financial incentives are often applied to motivate desirable performance across organisations in healthcare systems. In the 2016/2017 financial year, the National Health Service (NHS) in England set a national performance-based incentive to increase uptake of the influenza vaccination among frontline staff. Since then, the threshold levels needed for hospital trusts to achieve the incentive (ie, the targets) have ranged from 70% to 80%.
View Article and Find Full Text PDFBackground: The outcomes of elective surgery in public versus Independent Sector Healthcare Providers (ISHPs) are a matter of policy relevance and theoretical interest.
Methods: Retrospective study of all National Health Service (NHS) hospitals and ISHPs in England that provided NHS-funded elective surgery. We used data from the England-wide Hospital Episode Statistics to study 18 common surgical procedures performed between 2006 and 2019.
Background: Studies suggest that certain black and Asian minority ethnic groups experience poorer outcomes from COVID-19, but these studies have not provided insight into potential reasons for this. We hypothesised that outcomes would be poorer for those of South Asian ethnicity hospitalised from a confirmed SARS-CoV-2 infection, once confounding factors, health-seeking behaviours and community demographics were considered, and that this might reflect a more aggressive disease course in these patients.
Methods: Patients with confirmed SARS-CoV-2 infection requiring admission to University Hospitals Birmingham NHS Foundation Trust (UHB) in Birmingham, UK between 10 March 2020 and 17 April 2020 were included.
Background & Aims: There are insufficient population-level data on the effects of primary sclerosing cholangitis (PSC) in patients with inflammatory bowel disease (IBD).
Methods: We identified incident cases of IBD, with PSC (PSC-IBD) and without, from April 2006 to April 2016 and collected data on outcomes through April 2019. We linked data from national health care registries maintained for all adults in England on hospital attendances, imaging and endoscopic evaluations, surgical procedures, cancer, and deaths.