Publications by authors named "Hannah Buttkus"
Angew Chem Int Ed Engl
November 2024
Article Synopsis
- There is a need for effective methods to integrate deuterium into carbon compounds, especially in later stages of synthesis.
- A new synthetic approach for hydrogen isotope exchange (HIE) has been developed using hexafluorophosphate (PF) and deuterated hexafluoroisopropanol (HFIP-d) under mild, ambient conditions.
- This method achieves high yields in deuterating a variety of aromatic compounds and relies on the activation of the P-F bond by HFIP-d through H-bonding, facilitating the formation of deuterated molecules that could be useful in various chemical applications, including pharmaceuticals.
