Publications by authors named "Hannah Busch"
Recent advances in computational methods like AlphaFold have transformed structural biology, enabling accurate modeling of protein complexes and driving applications in drug discovery and protein engineering. However, predicting the structure of systems involving weak, transient, or dynamic interactions, or of complexes with disordered regions, remains challenging. Nuclear Magnetic Resonance (NMR) spectroscopy offers atomic-level insights into biomolecular complexes, even in weakly interacting and dynamic systems.
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- - The study examines how the rate of environmental change impacts the adaptation of populations, using the lytic RNA bacteriophage Φ6 as a model system exposed to varying rates of heat shocks to improve thermostability.
- - Results revealed that populations gradually exposed to higher temperatures showed better survival rates during initial heat exposure compared to those facing rapid increases in temperature.
- - While certain mutations enhanced viral thermostability, others improved growth rates, indicating that different selective pressures can affect adaptation outcomes in evolving environments.