Publications by authors named "Hannah Brenke"
Article Synopsis
- Acetyl-coenzyme A carboxylases (ACCs) play a critical role in fatty acid metabolism by converting acetyl-CoA to malonyl-CoA, but research on insect ACCs is limited compared to those in humans, plants, and microbes.*
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- Noctuid moths, like Trichoplusia ni, are major agricultural pests with insecticide resistance, prompting the exploration of new insecticides targeting ACCs; however, there is a lack of structural information for effective drug design.*
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- This study presents a 3.12 Å cryo-EM structure of the carboxyltransferase domain of T. ni ACC, offering insights into its unique interactions and potential applications in
