Publications by authors named "Hannah Breeze-Jones"
Collagen remodeling contributes to many physiologic and pathologic processes. In primary tumors, the linearization of collagen fibers promotes cancer cell invasion and metastasis and is indicative of poor prognosis. However, it remains unknown whether there are endogenous inhibitors of collagen linearization that could be exploited therapeutically.
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- - Collagen linearization, which is associated with aggressive tumors, enhances cancer cell invasion and metastasis, and this process can occur without mechanical forces from the cells.
- - The study identifies WISP1 (CCN4), a matricellular protein secreted by tumor cells, as a crucial factor that binds to type I collagen, leading to its linearization in both cell-free and tumor environments.
- - Increased levels of WISP1 in patient tumors are linked to quicker progression of cancer and poorer patient outcomes, highlighting its role in promoting metastasis through collagen linearization.