Publications by authors named "Hannah Billig"
Article Synopsis
- Stent under-expansion can increase risks like neoatherosclerosis and stent thrombosis, especially in cases of severe coronary calcification, and intravascular lithotripsy (IVL) can help prevent this by ensuring proper stent expansion.
- A 62-year-old male with unstable angina was treated for high-grade stenosis in the right coronary artery but experienced stent under-expansion despite multiple attempts to dilate it, including using ultra-high-pressure balloons.
- The successful use of IVL led to complete stent expansion at a lower pressure, illustrating its effectiveness and safety in treating stent under-expansion, which is critical for preventing complications like restenosis and thrombosis.
Aims: To quantify greyzone fibrosis (GZF) in patients after acute myocardial infarction (MI) and to evaluate its correlation with MI-free survival and improvements in left ventricular ejection fraction (LVEF) compared with the established risk factors high-sensitivity cardiac troponin T (hs-cTnT) and Late Gadolinium Enhancement (LGE).
Methods And Results: The study involved 176 patients who experienced acute MI and underwent cardiac magnetic resonance (CMR) prior to hospital discharge, followed by a second CMR on average six months later. LGE was quantified in both examinations, a separate analysis of the GZF was conducted only in the follow-up CMR after resolution of the initial infarct edema.
Lactate and glucose are widely used biochemical parameters in current predictive risk scores for cardiogenic shock. Data regarding the relationship between lactate and glucose levels in cardiogenic shock are limited. Thus, we aimed to analyze glucose and lactate as early markers for in-hospital mortality in cardiogenic shock.
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- Delayed coronary obstruction (DCO) is a rare but serious complication that can occur after transcatheter aortic valve implantation (TAVI), often affecting the left main coronary artery due to issues like prosthesis endothelialization or thrombus formations.
- A 73-year-old patient experienced recurrent ventricular tachycardia and syncope months after TAVI, leading to the discovery of DCO caused by a calcium nodule through cardiac computed tomography angiography (CCTA).
- CCTA proved to be a valuable diagnostic tool that helped identify the obstruction and guide the subsequent percutaneous coronary intervention, highlighting the potential risks associated with TAVI.
Critical care cardiology (CCC) in the modern era is shaped by a multitude of innovative treatment options and an increasingly complex, ageing patient population. Generating high-quality evidence for novel interventions and devices in an intensive care setting is exceptionally challenging. As a result, formulating the best possible therapeutic approach continues to rely predominantly on expert opinion and local standard operating procedures.
View Article and Find Full Text PDFAortic valve stenosis (AS) development is driven by distinct molecular and cellular mechanisms which include inflammatory pathways. Toll-like-receptor-3 (TLR3) is a lysosomal pattern-recognition receptor that binds double-stranded RNA and promotes pro-inflammatory cellular responses. In recent years, TLR3 has emerged as a major regulator of vascular inflammation.
View Article and Find Full Text PDFHead and neck squamous cell carcinoma (HNSCC) remains a clinical challenge and identification of novel therapeutic targets is necessary. The receptor tyrosine kinase AXL has been implicated in several tumor entities and a selective AXL small molecule inhibitor (BGB324) is currently being tested in clinical trials for patients suffering from non-small cell lung cancer or acute myeloid leukemia. Our study investigates AXL expression during HNSCC progression and its use as a potential therapeutic target in HNSCC.
View Article and Find Full Text PDFBackground: Although head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumour entity worldwide, it remains a clinical challenge. Large-scale explorative genomic projects have identified several genes as potential targets for therapy, including fibroblast growth factor receptor 3 (FGFR3).
Aims: The aim of this study was to investigate the biological significance of wild-type and mutated FGFR3 to evaluate its potential as a novel therapeutic target in HNSCC.