Publications by authors named "Hannah Auwerx"
PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells.
Am J Physiol Renal Physiol
June 2023
Article Synopsis
- PCK1 (phosphoenolpyruvate carboxykinase 1) is a key enzyme in kidney cells that helps convert oxaloacetate to phosphoenolpyruvate and plays a role in maintaining metabolic processes such as gluconeogenesis and ammoniagenesis.
- Deleting PCK1 in kidney-specific knockout mice led to metabolic issues including hyperchloremic metabolic acidosis and altered metabolism, causing kidney injury and decreased ATP production.
- Enhancing PCK1 expression during chronic kidney disease improved renal function, highlighting its importance for acid-base balance, energy production, and overall tubular health.
Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries.
Front Med (Lausanne)
October 2021
Acute and chronic kidney disease are responsible for large healthcare costs worldwide. During injury, kidney metabolism undergoes profound modifications in order to adapt to oxygen and nutrient shortage. Several studies highlighted recently the importance of these metabolic adaptations in acute as well as in chronic phases of renal disease, with a potential deleterious effect on fibrosis progression.
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