Obstructive sleep apnea in young infants: Sleep position dependence and spontaneous improvement.

Objectives: The natural evolution of obstructive sleep apnea (OSA) in young infants is not established.

Methods: We re-evaluated 10-year pediatric sleep center infant polysomnography (PSG) data, excluding infants with syndromes, genetic defects, structural anomalies or periodic breathing > 5% of sleep time.

Results: Obstructive events > 1 h were evident in 255 infants, of which 91 were eligible for the study.

Lymphomas in cartilage-hair hypoplasia - A case series of 16 patients reveals advanced stage DLBCL as the most common form.

Background: Patients with cartilage-hair hypoplasia (CHH) have an increased risk of malignancy, particularly non-Hodgkin lymphoma and basal cell carcinoma. The characteristics, clinical course, response to therapy and outcome of lymphomas in CHH remains unexplored.

Methods: We assessed clinical features of lymphoma cases among Finnish patients with CHH.

Obstructive sleep apnea is position dependent in young infants.

Background: Obstructive sleep apnea in infants with Pierre Robin sequence is sleep-position dependent. The influence of sleep position on obstructive events is not established in other infants.

Methods: We re-evaluated ten-year pediatric sleep center data in infants aged less than six months, with polysomnography performed in different sleep positions.

Pierre Robin sequence causes position-dependent obstructive sleep apnoea in infants.

Introduction: Obstructive sleep apnoea (OSA) and feeding difficulties are key problems for Pierre Robin sequence (PRS) infants. OSA management varies between treatment centres. Sleep positioning represents the traditional OSA treatment, although its effectiveness remains insufficiently evaluated.

Comparison of the severity and outcome of invasive pneumococcal infections in children and adults.

In a population-based observational study of 285 patients with positive blood culture for pneumococci, we found that the course and outcome of invasive pneumococcal infections differ considerably between adults and children. None of the children died, whereas the infection was fatal for 15% (35/229) of the adults (P<0.001).