Publications by authors named "Hanna-Leena Hietaranta-Luoma"
Introduction: The APOE ε4 allele predisposes to high cholesterol and increases the risk for lifestyle-related diseases such as Alzheimer's disease and cardiovascular diseases (CVDs). The aim of this study was to analyse interrelationships of APOE genotypes with lipid metabolism and lifestyle factors in middle-aged Finns among whom the CVD risk factors are common.
Methods: Participants (n = 211) were analysed for APOE ε genotypes, physiological parameters, and health- and diet-related plasma markers.
Background: The APOE ε4 allele is associated with higher risks of cardiovascular diseases and Alzheimer disease than ε3 and ε2.
Objectives: We studied the effectiveness of dietary and lifestyle guidance and personal genetic risk information [ε4 carrier (ε4+); ε4 noncarrier (ε4-)] as motivators for a healthier lifestyle.
Methods: A total of 188 healthy Finnish volunteers (82.
Aim: This observational follow-up study was designed to assess the long-term behavioural and clinical effects of receiving personal genetic risk information. The information disclosed was the carrier status of the apolipoprotein E (APOE)alleles, which differentially contribute to the genetic risk for cardiovascular disease (CVD) and Alzheimer's disease.
Methods: This study forms a continuum with a previous 1-year intervention (2010-2011) monitoring the effects of disclosing the carrier status of the APOE ε4risk allele.
Article Synopsis
- The study aimed to evaluate how receiving personal genetic information, specifically about the apoE genotype, influences health-related behaviors, especially regarding diet and lifestyle changes.
- A total of 107 healthy adults participated over a year, having their dietary habits, alcohol consumption, and exercise tracked at multiple points, comparing groups based on their apoE risk levels.
- Results showed that those with the high-risk apoE genotype improved their dietary fat quality more significantly after receiving genetic health advice than those in low-risk and control groups, indicating that personal genetic insights can prompt some immediate behavioral changes but may not sustain over time.