ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates.

Eukaryotic ribosome assembly is an intricate process that involves four ribosomal RNAs, 80 ribosomal proteins, and over 200 biogenesis factors that take part in numerous interdependent steps. This complexity creates a large genetic space in which pathogenic mutations can occur. Dead-end ribosome intermediates that result from biogenesis errors are rapidly degraded, affirming the existence of quality control pathway(s) that monitor ribosome assembly.

A FOXC2 inhibitor, MC-1-F2, as a therapeutic candidate for targeting EMT in castration-resistant prostate cancer.

Androgen deprivation therapy (ADT) is the major treatment option for advanced prostate cancer. However, prostate cancer can develop into androgen-independent castration-resistant prostate cancer (CRPC) which is resistant to ADT. An alternative treatment strategy for CRPC can be targeting the epithelial-mesenchymal transition (EMT).

Perfectionism, Prolonged Stress Reactivity, and Depression: A Two-Wave Cross-Lagged Analysis.

Perfectionism is a vulnerability factor for a wide array of psychopathology. Despite much evidence suggesting dysregulated stress response as an intermediary process that links perfectionism to psychopathology, the lack of a cross-lagged examination deterred researchers from making causal interpretations. This study examined the directionality of effects among perfectionism dimensions, stress reactivity, and depression.

University Students Adjusting to COVID-19 Stressors: Exploratory and Confirmatory Factor Analyses of the COVID-19 Stressors Questionnaire.

The psychological effects of COVID-19 have been documented in the past year, but scarce literature exists on the nature of COVID-19 stressors. Using a random split sample of 1199 young adult university students, results of exploratory factor analyses (EFA) identified a four-factor structure in the COVID-19 Stressors Questionnaire (C19SQ), which were labeled Resource Constraints, Social Restrictions, Future Uncertainty, and Health Concerns. This model was supported by a confirmatory factor analysis (CFA) when run on the other split sample of 1139 university students.

Perfectionism and alcohol-related problems: The role of procrastination.

Objective: College drinking is a significant individual and societal problem, and thus, identifying risk factors to alcohol-related problems has been an important line of inquiry. Adding to this rich literature, the current study examined whether perfectionism dimensions were associated with alcohol-related problems and whether a poor self-regulation process linked these associations.

Participants: A total of 410 university students completed measures pertaining to perfectionism, procrastination, and negative consequences of alcohol use.

Daily change patterns in mindfulness and psychological health: A pilot intervention.

Objective: This study examined the differences in first-year college students' daily change trajectories in subjective happiness, depression, anxiety, stress, and state mindfulness.

Method: A 5-day, online mindfulness-based intervention (MI) condition and stress management (SM) condition were employed in 247 first-year college students.

Results: Students in both the MI and SM conditions displayed similar significant linear declines in anxiety and stress, but there were significant differences between the two conditions, including: (1) the MI condition showing a significant linear increase in subjective happiness compared with no change in the SM condition and (2) the SM condition showed a significant linear decrease in depression compared to no significant change in the MI condition.

Profiles of mindfulness and difficulties in emotion regulation and links to work-family-school conflict.

We explored latent profiles based on mindfulness and difficulties in emotion regulation scores, and investigated each profiles' relations to work-family-school conflict (WFSC). A total of 194 first year college students (64.4% women) participated in this study.

A review and meta-analysis of perfectionism interventions: Comparing face-to-face with online modalities.

Extending Lloyd, Schmidt, Khondoker, and Tchanturia (2015), this review and meta-analysis evaluated the effectiveness of randomized controlled trials aimed at reducing perfectionism and associated symptoms of depression and anxiety. Of particular interest was the examination of a moderator of delivery method (face-to-face vs. online) in testing the effectiveness of psychological interventions.

The advising alliance for international and domestic graduate students: Measurement invariance and implications for academic stress.

We expanded the focus of a prior study of international graduate student advising relationships (Rice et al., 2009) to examine advising experiences of both international and domestic students. International (n = 434) and domestic (n = 387) students completed the Advisory Working Alliance Inventory (AWAI-S; Schlosser & Gelso, 2001) and measures of advising experiences, perceived academic stress, and desire to change advisor.

The CES-D as a Measure of Psychological Distress Among International Students: Measurement and Structural Invariance Across Gender.

Detecting psychological distress among international students can be challenging given diverse languages, cultural backgrounds, and lack of refined measurement properties of measures tailored to international students. Despite the challenges, ensuring that a psychological distress measure works effectively has considerable potential value for assessment purposes. The current study evaluates the measurement properties of a short 10-item version of Radloff's Center for Epidemiologic Studies Depression Scale (CES-D).

Factor structure of the perfectionistic self-presentation scale in Korea.

This study explored the factor structure of the Korean version of the Perfectionistic Self-Presentation Scale, originally developed by Hewitt and colleagues in 2003 with three factors (Perfectionistic Self-promotion, Non-display of Imperfection, and Non-disclosure of Imperfection). In Study 1, a confirmatory factor analysis was performed on the Korean version with 27 items for 151 Korean college students, but the model fit was poor. Subsequently, an exploratory factor analysis was conducted, and the results yielded three factors as found in Hewitt, et al.