Systemic criticality-a new assessment concept improving the evidence basis for CI protection.

With high certainty, extreme weather events will intensify in their impact within the next 10 years due to climate change-induced increases in hazard probability of occurrence and simultaneous increases in socio-economic vulnerability. Data from previous mega-disasters show that losses from disruptions of critical services surpass the value of direct damages in the exposed areas because critical infrastructures [CI] are increasingly (inter-) dependent. Local events may have global impacts.

Cone Beam CT-Based Daily Adaptive Planning or Defined-Filling Protocol for Neoadjuvant Gastric Cancer Radiation Therapy: A Comparison.

Purpose: This study aimed to investigate, in the setting of neoadjuvant gastric irradiation with integrated boost, whether cone beam computed tomography (CBCT)-based adaptive radiation therapy compared with a defined-filling protocol would be beneficial in terms of feasibility and achieving daily reproducible dose volume indexes of the planning target volume (PTV) and organs at risk (OARs) and workflow.

Methods And Materials: Planning computed tomography (PCT) and 25 CBCT scans of a previously treated patient were used, and neoadjuvant therapy of gastric carcinoma was simulated offline. PTVs and OARs were defined per the TOPGEAR protocol (PTV: 45 Gy/1.