Publications by authors named "Hanna M Valtonen"
Article Synopsis
- A study diagnosed 191 patients with DSM-IV Bipolar Disorder I or II, examining sociodemographic and clinical characteristics, including comorbidities and neuroticism, at intake and follow-up.
- Approximately 74% of patients had a positive family history (FH) of mood disorders or alcoholism, with 55% related to mood disorders and 36% to alcoholism.
- Patients with a positive FH of both mood disorders and alcoholism had a significantly higher chance (odds ratio of 4.8) of developing anxiety disorders, indicating that family history influences the bipolar patients' mental health course and comorbidities.
P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts.
Am J Med Genet B Neuropsychiatr Genet
June 2011
We investigated the effect of nine candidate genes on risk for mood disorders, hypothesizing that predisposing gene variants not only elevate the risk for mood disorders but also result in clinically significant differences in the clinical course of mood disorders. We genotyped 178 DSM-IV bipolar I and II and 272 major depressive disorder patients from three independent clinical cohorts carefully diagnosed with semistructured interviews and prospectively followed up with life charts for a median of 60 (range 6-83) months. Healthy control subjects (n = 1322) were obtained from the population-based national Health 2000 Study.
View Article and Find Full Text PDFObjective: To test two hypotheses of psychiatric comorbidity in bipolar disorder (BD): (i) comorbid disorders are independent of BD course, or (ii) comorbid disorders associate with mood.
Methods: In the Jorvi Bipolar Study (JoBS), 191 secondary-care outpatients and inpatients with DSM-IV bipolar I disorder (BD-I) or bipolar II disorder (BD-II) were evaluated with the Structured Clinical Interview for DSM-IV Disorders, with psychotic screen, plus symptom scales, at intake and at 6 and 18 months. Three evaluations of comorbidity were available for 144 subjects (65 BD-I, 79 BD-II; 76.
Background: We investigated the adequacy of maintenance phase pharmacotherapy received by psychiatric in- and outpatients with bipolar I or II disorder, including patients both with and without a clinical diagnosis of bipolar disorder (BD).
Methods: In the Jorvi Bipolar Study (JoBS), a naturalistic prospective 18-month study representing psychiatric in- and outpatients with DSM-IV BD I and II in three Finnish cities, we studied the adequacy of pharmacological treatment received by 154 patients during the first maintenance phase after index episode. Information on treatments prescribed during the follow-up was gathered in interviews and from psychiatric records.
Background: Learning to detect prodromal symptoms is a key element of psychosocial treatment of bipolar disorder (BD). However, previous studies have described only prodromes of manic and depressive phases of BD I patients, while information on prodromes in BD II, or other phases is lacking.
Methods: The Jorvi Bipolar Study included 191 in- and outpatients with DSM-IV BD (90 BD I, 101 BD II) in any acute phase of illness at baseline.
Article Synopsis
- The study compares the course of bipolar disorder type II (BD II) and type I (BD I) to see if BD II is more depressive.
- Patients with BD II were found to spend more time in depressive states compared to those with BD I, indicating higher vulnerability.
- The higher incidence and frequency of depressive phases in BD II patients contributed to their increased depressive symptoms and outcomes.
Objective: To obtain a comprehensive view of differences in current comorbidity between bipolar I and II disorders (BD) and (unipolar) major depressive disorder (MDD), and Axis I and II comorbidity in BD in secondary-care psychiatric settings.
Method: The psychiatric comorbidity of 90 bipolar I and 101 bipolar II patients from the Jorvi Bipolar Study and 269 MDD patients from the Vantaa Depression Study were compared. We used DSM-IV criteria assessed by semistructured interviews.