Publications by authors named "Hanna Lenhoff"

Background: Use of d,l-sotalol for rhythm control in patients with atrial fibrillation (AF) has raised safety concerns. Previous randomized studies are few and not designed for mortality outcome.

Objective: The purpose of this study was to compare the incidences of mortality and ventricular arrhythmias in AF patients treated with d,l-sotalol for rhythm control vs matched control patients treated with cardioselective beta-blockers.

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Article Synopsis
  • - The study examines the risk of ventricular arrhythmias in patients on QT-prolonging medications like sotalol after cardioversion of atrial fibrillation to sinus rhythm, specifically focusing on changes in the corrected QT interval (QTc) over a 24-hour period.
  • - Fifty patients were monitored using Holter recordings for 24 hours following cardioversion, with 27 on sotalol and 23 on metoprolol, revealing significant diurnal variation in heart rate and QTc, especially in those on sotalol.
  • - Results showed that 22% of patients on sotalol experienced over 20% of their heartbeats with QTc exceeding 500 ms, indicating a higher risk for pro
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Introduction: Psychosocial factors influence the risk of developing hypertension. Personality traits have a modulating effect against the harmful influences of psychosocial factors.

Aim: Through a longitudinal clinical study consisting of men and women aged 35 and 55 at the baseline in Estonia and Sweden, to assess the influence of psychosocial factors and personality traits resulting in arterial hypertension.

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Background: Sotalol is recommended to prevent relapse of atrial fibrillation after cardioversion (CV). Sotalol prolongs the action potential by blocking the rapid component of the delayed rectifier potassium current, which results in corrected QT (QTc) prolongation on the electrocardiogram. Pronounced QTc prolongation may lead to proarrhythmias and sudden death.

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Aim: In the 1990s, several studies noted a large gap in life expectancy between Western and Eastern European countries. It was speculated that this could be explained by environmental pollution, socioeconomic factors, lifestyle and psychosocial stress. A weakness in addressing the issue has been the lack of prospective studies with mortality as end point.

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