Publications by authors named "Hanna Kristiina Isotalus"
Introduction: Technology holds the potential to track disease progression and response to neuroprotective therapies in Parkinson's disease (PD). The sit-to-stand (STS) transition is a frequently occurring event which is important to people with PD. The aim of this study was to demonstrate an automatic approach to quantify STS duration and speed using a real-world free-living dataset and look at clinical correlations of the outcomes, including whether STS parameters change when someone withholds PD medications.
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- - The study investigates the potential of turning parameters, captured through video, to serve as biomarkers for assessing disease progression in Parkinson's disease (PD) and examines the impact of clinician observation on turning outcomes.
- - Conducted over 5 days with 11 PD participants and 11 control participants in a home-like environment, the research analyzed 3869 turns from high-resolution video, finding significant differences in turning metrics between medication states.
- - Results indicate that turning parameters correlate positively with established clinical rating scales, suggesting that real-world turning behavior can effectively distinguish PD medication states and provides a method for validating digital health outcomes.
Rationale: Parkinson's disease (PD) impairs working memory (WM)-the ability to maintain items in memory for short periods of time and manipulate them. There is conflicting evidence on the nature of the deficits caused by the disease, and the potential beneficial and detrimental effects of dopaminergic medication on different WM processes.
Objectives: We hypothesised that PD impairs both maintenance and manipulation of items in WM and dopaminergic medications improve this in PD patients but impair it in healthy older adults.