Publications by authors named "Hanna Coppola"
Individuals born after intrauterine growth restriction (IUGR) are at risk of developing cardiovascular diseases (CVDs). Endothelial dysfunction plays a role in the pathogenesis of CVDs; and endothelial colony-forming cells (ECFCs) have been identified as key factors in endothelial repair. In a rat model of IUGR induced by a maternal low-protein diet, we observed an altered functionality of ECFCs in 6-month-old males, which was associated with arterial hypertension related to oxidative stress and stress-induced premature senescence (SIPS).
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- - Metabolic syndrome (MetS) is a combination of health issues like obesity, insulin resistance, high blood pressure, and liver disease, with individuals born after intrauterine growth restriction (IUGR) facing higher risks of these conditions later in life.
- - A study involving rats showed that male offspring with IUGR (induced by a low-protein diet during pregnancy) had increased visceral fat, glucose intolerance, and liver damage compared to control males, while no significant differences were noted in female offspring.
- - The livers of IUGR males exhibited signs of stress-induced premature senescence and oxidative stress, pointing to impaired liver function and structure, suggesting the need for targeted therapies to mitigate the negative impacts of IUG
Article Synopsis
- Infants born with intrauterine growth restriction (IUGR) are at heightened risk for developing high blood pressure later in life due to issues with their endothelial cells, which are key in vascular health.* -
- A study using a rat model showed that male offspring from IUGR pregnancies had higher blood pressure and fewer blood vessels compared to controls, indicating a problem with their endothelial colony-forming cells (ECFCs). * -
- ECFCs from IUGR rats displayed decreased ability to proliferate and form new blood vessels, linked to oxidative stress and cellular damage, which may contribute to the hypertension observed in these individuals as adults.*