Publications by authors named "Hanming Yu"
Background: N, N-diethyl-m-toluamide (DEET), an active ingredient prevalent in insect repellents, has its effects on human health under ongoing debate and scrutiny.
Objective: This study aimed to investigate the association between exposure to DEET and arthritis outcomes within the broader adult demographic, leveraging data obtained from the National Health and Nutrition Examination Survey (NHANES).
Methods: 3-diethyl-carbamoyl benzoic acid (DCBA) was used as a specific indicator of DEET exposure.
The involvement of HDAC3 in the pathogenesis of lung injury and pulmonary fibrosis.
Front Immunol
October 2024
Article Synopsis
- Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious lung conditions linked to high death rates due to intense lung inflammation, and there's a pressing need for new treatments as current pharmacological options are lacking.
- Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by irreversible lung damage and excessive scar tissue formation, with limited treatment options and no cure available.
- HDAC3, a key protein involved in regulating gene expression and various cellular processes, is investigated for its potential therapeutic roles in treating ALI, ARDS, and IPF by targeting the underlying inflammation and tissue remodeling mechanisms.
Regulation of idiopathic pulmonary fibrosis: a cross-talk between TGF- signaling and MicroRNAs.
Front Med (Lausanne)
September 2024
Pulmonary fibrosis (PF) is a highly complex and challenging disease affecting the respiratory system. Patients with PF usually have an abbreviated survival period and a consequential high mortality rate after the diagnosis is confirmed, posing serious threats to human health. In clinical practice, PF is typically treated by antifibrotic agents, such as Pirfenidone and Nintedanib.
View Article and Find Full Text PDFObjective: Arthritis has been postulated as a prevalent potential risk factor for the emergence of dementia and cognitive impairment. This conjecture prompted an examination of the correlation between arthritis and cognitive impairment using the National Health and Nutrition Examination Survey (NHANES) repository. The analysis was meticulously adjusted for potential confounders such as age and assorted systemic comorbidities, to ensure robustness in the results obtained.
View Article and Find Full Text PDFArticle Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a serious and uncurable lung disease characterized by damage to lung tissue and abnormal healing processes, which can lead to severe lung damage.
- There is ongoing research into the role of macrophages, specifically their different types (M1 and M2), in the development of fibrosis, with M2 macrophages being linked to dysfunctional tissue repair.
- The article highlights histone deacetylase 6 (HDAC6) as a key player in IPF and suggests its potential as a target for new treatments.
Natural compounds have been candidates for anticancer medicine over the last 20 years. During the process of isolating seed oil from L., yellow and green pigments containing multiple compounds with an aromatic structure were identified.
View Article and Find Full Text PDF