Multi-label feature selection based on HSIC and sparrow search algorithm.

Feature selection has always been an important topic in machine learning and data mining. In multi-label learning tasks, each sample in the dataset is associated with multiple labels, and labels are usually related to each other. At the same time, multi-label learning has the problem of "curse of dimensionality".

Algorithm for frequency capture and rectification in a low-orbit satellite IoT communication network.

In satellite communication systems, due to relative motion between satellites and that between satellites and the ground, the resulting Doppler frequency offset adversely affects communication synchronization. In this research, Doppler frequency offset compensation and phase offset compensation method eliminate the influence of the Doppler effect on synchronization. The proposed algorithm divides frequency estimate into two steps, coarse and precision.

Recessive/dominant model: Alternative choice in case-control-based genome-wide association studies.

An additive genetic model is usually employed in case-control-based genome-wide association studies. The model usually encodes "AA", "Aa" and "aa" ("a" represents the minor allele) as three different numbers, implying the contribution of genotype "Aa" to the phenotype is different from "AA" and "aa". From the perspective of biological phenomena, the coding is reasonable since the phenotypes of lives are not "black and white".

coPLINK: A complementary tool to PLINK.

In genome-wide association studies (GWAS), a wide variety of analysis tools have been designed, leading to various formats of GWAS data. How to convert a dataset in non-PLINK format into PLINK format to use its powerful analysis performance, or to convert a dataset in PLINK format into the format of other analysis tools, is a problem that needs to be faced and solved. To address this issue, we developed a tool called coPLINK, a complementary tool to PLINK, to cooperate with PLINK to implement the conversions of GWAS data formats and to provide some additional functions, such as data files comparison.

Provincial-level outcomes of China's 'Reducing maternal mortality and eliminating neonatal tetanus' program.

To determine whether the nationwide program 'Reducing maternal mortality and eliminating neonatal tetanus' contributed to the rapid decline in China's maternal mortality ratio (MMR) and neonatal tetanus elimination by enhancing hospital delivery, we compared MMR and neonatal tetanus incidence rate (NTR) reductions by province from 2000 to 2013. The difference-in-difference method was used to analyze the program effect. Long-term effects were analyzed relative to MMR and NTR in 2000 and 2002, respectively, while short-term effects in a given year were analyzed relative to MMR and NTR in the preceding year.

Long non-coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-29c-3p in gastric cancer.

Objective: Long non-coding RNA (lncRNA) has become an important regulator of many human malignancies. However, the biological role and clinical significance of most lncRNA in gastric cancer (GC) remain unclear.

Methods: We investigate the biological function, mechanism of action and clinical expression of lncRNA MYOSLID in GC.

Density distribution of gene expression profiles and evaluation of using maximal information coefficient to identify differentially expressed genes.

The hypothesis of data probability density distributions has many effects on the design of a new statistical method. Based on the analysis of a group of real gene expression profiles, this study reveal that the primary density distributions of the real profiles are normal/log-normal and t distributions, accounting for 80% and 19% respectively. According to these distributions, we generated a series of simulation data to make a more comprehensive assessment for a novel statistical method, maximal information coefficient (MIC).

Maximal information coefficient applied to differentially expressed genes identification: A feasibility study.

Background: The main obstacle encountered in microarray technology is how to mine the valuable information under the profiles and study the genes function.

Objective: Maximal information coefficient (MIC) is a novel, non-parametric statistic that has been successfully applied to genome-wide association studies and differentially gene and miRNA expression analysis. However, the data used in these applications are not gold standard but real data.

Analysis of connection networks among miRNAs differentially expressed in early gastric cancer for disclosing some biological features of disease development.

This paper first identified differentially expressed miRNAs associated with early gastric cancer and then respectively constructed relevant connection networks among the identified differentially expressed miRNAs that corresponded to early gastric cancer and control tissues. Twenty-three differentially expressed miRNAs were identified, 18 of which were different with the related results on the same data, and they provide great discriminatory power between patients and controls. There are not only conserved unchangeable sub-networks but also different sub-networks between the two connection networks.

Biocomputional construction of a gene network under acid stress in Synechocystis sp. PCC 6803.

Acid stress is one of the most serious threats that cyanobacteria have to face, and it has an impact at all levels from genome to phenotype. However, very little is known about the detailed response mechanism to acid stress in this species. We present here a general analysis of the gene regulatory network of Synechocystis sp.

Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.

The drugs that are currently used to treat pulmonary hypertension (PH) lack the ability to inhibit or reverse the pulmonary vascular remodeling that occurs during the course of the disease. We propose a novel method that combines the therapeutic powers of the potassium channel opener pinacidil and the statin drug simvastatin. These two drugs do not share similar mechanisms of treating PH.

Interface enhancement of glass fiber/vinyl ester composites with carbon nanotubes synthesized from ethanol flames.

Multi-walled carbon nanotubes synthesized from ethanol flames (F-MWCNTs) and nanotubes functionalized by n-hexadecylamine (H-MWCNTs) were applied to the preparation of glass fiber/vinyl ester composites by overcoating the original glass fiber. Scanning electron microscopy of the composites containing multi-walled carbon nanotubes (MWCNTs) showed better bonding between the glass fiber and the resin matrix which may be attributed to the existence of a flexible interphase introduced by the nanotubes. It was found that the bonding in the composites treated with H-MWCNTs was much stronger.

[Effect of polycythemia on hypoxia induced pulmonary hypertension and pulmonary vascular remodeling in rats].

Objective: To investigate the effect of polycythemia on hypoxia induced pulmonary hypertension and pulmonary vascular remodeling in rats.

Methods: The healthy female Sprague-Dawley rats were randomly divided into 3 groups: normoxia control group (C group), hypoxia group (H group), hypoxia + different doses of human recombine hemopoietin (rEPO) group. All rats in hyoxia groups were exposed to hypoxia, 8 hours every day, for 21 days.

[Changes of MMP-2,9 and TIMP-1 expressions in rats with pulmonary arterial hypertension after captopril and losartan interventions].

Objective: To determine the effect of captopril and losartan on the expressions of matrix metalloproteinase-2,9 (MMP-2,9) and metalloproteinase-1 (TIMP-1) in rats with pulmonary arterial hypertension, and the mechanisms of captopril and losartan in intervening the development of pulmonary arterial hypertension.

Methods: Forty male Spraque-Dawley rats were divided into 4 groups randomly: pulmonary arterial hypertension (created by pneumonectomy plus MCT injection) model group (PAH Model), PAH model treated with captopril [PAH+Cap 10 mg/(kg x d)], losartan group [PAH+Los 15 mg/(kg x d)] and normal control group(Control). The mPAP, weight ratio of RV to LV+S, neointima formation, relative thickness of small pulmonary arteries, and degree of muscularization of non-muscular arterioles were measured at day 35.