Publications by authors named "Hanlu Fang"
Article Synopsis
- Cuproptosis is a newly identified type of programmed cell death that is linked to neuroendocrine tumors and metabolism, but its specific role in Hepatocellular carcinoma (HCC) has not been thoroughly explored.
- Researchers used bioinformatics analyses to construct a prognostic gene model and a competing endogenous RNA (ceRNA) network to examine the relationship between cuproptosis-related genes (CRGs) and various clinical factors in HCC patients.
- The study identified a 3-gene signature associated with CRGs that effectively predicts HCC patient prognosis, revealing correlations with immune factors and suggesting potential new biomarkers and treatment targets.
Background: Previous studies have revealed the significant roles of SHC SH2 domain-binding protein 1 (SHCBP1) in occurrence and progression of cancers, but there is no pan-cancer analysis of SHCBP1.
Methods: In this study, we explored the potential carcinogenic role of SHCBP1 across 33 tumors from the TCGA and GTEx databases. We investigated SHCBP1 expression, prognosis, genetic alterations, tumor mutational burden (TMB) score, microsatellite instability (MSI) and tumor microenvironment from TIMER2, GEPIA2, UALCAN and cBioPortal databases.
Recent studies have indicated that pyroptosis may participate in the regulation of tumorigenesis and immune microenvironment. However, the role of pyroptosis-related genes (PRGs) in pancreatic adenocarcinoma (PAAD) remains unclear. Through multiple bioinformatics analysis, we constructed a prognostic gene model and competing endogenous RNA network.
View Article and Find Full Text PDFThe lactation period is an important period for individual development and a sensitive period for the behavioral phenotypes and plasticity of individual offspring. Early life experiences (e.g.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) is a major public health problem in humans. The imbalance of mitochondrial function has been discovered to be closely related to the development of cancer recently. However, the role of mitochondrial-related genes in HCC remains unclear.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) is a major human health concern. Increasing evidence has demonstrated that ubiquitin ligase E4B (UBE4B) may be involved in the occurrence and development of various human cancers and may affect prognosis. However, the specific role and mechanism of UBE4B in HCC is unclear.
View Article and Find Full Text PDF