Four-quadrant retarder array imaging spectropolarimeter for the full Stokes vector spectrum.

Aiming at the major demand for polarization information gap in earth observation and space exploration, we proposed a four-quadrant retarder array imaging spectropolarimeter (FQRAISP) in view of the existing technical problem of the spectral resolution degradation along with spectral aliasing crosstalk. The optical schematic diagram of the FQRAISP together with its interference model was conceptually described, and the effectiveness of the scheme was validated through the experimental simulation, which demonstrated the competitive efficiency and accuracy in the proposed FQRAISP. The FQRAISP could restore the incident Stokes vector spectrum without any errors, and the inversion accuracy was increased by seven times, avoiding the spectrum aliasing and channel filtering in the channel modulation.

Securinine Promotes Neuronal Development and Exhibits Antidepressant-like Effects via mTOR Activation.

Impaired differentiation of newborn neurons or abnormalities at the synapses resulted from stress maladaptation could be the key etiology of depression. Recent studies have shown that mTOR, a crucial factor for neuronal differentiation and synapse development, acts as a common factor that mediates the rapid antidepression effects of several new-class antidepressants. In this study, the antidepressant-like activity of securinine, an alkaloid that has central nervous system stimulation ability, was investigated.

7-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4E-hepten-3-one alleviates Aβ induced cytotoxicity through PI3K-mTOR pathways.

Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. Increasing evidence has shown that β-amyloid protein (Aβ) production is the key pathological cause of AD. 7-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4E-hepten-3-one (AO-2), a natural diarylheptanoid, is previously found to have activities in neuronal differentiation and neurite outgrowth, and its analogue shows protective effects against Aβ.