Publications by authors named "Hank Jones"
Article Synopsis
- Scientists are studying how DNA sequences work to control gene expression in different cell types, but it's been hard to figure out how these sequences affect gene activity.
- They created a new method called Variant-FlowFISH to test many tiny changes in DNA and see how they change gene expression, using advanced tools like CRISPR.
- By testing 672 different changes, they found that many can really change gene activity, and some changes work differently in different types of cells, which helps improve predictions about how genes are controlled.
Article Synopsis
- - This study identifies over 13 million interactions between transcriptional enhancers and their target genes across various cell types and tissues, which is crucial for understanding how gene regulation influences diseases.
- - Utilizing a new predictive model called ENCODE-rE2G, the researchers achieved high accuracy in predicting enhancer-gene interactions, supported by a robust dataset from CRISPR experiments and genetic mapping.
- - The findings highlight not only the role of enhancers and their contacts with promoters but also additional factors like promoter types and enhancer interactions that affect gene regulation, creating a detailed resource for future genetic research.
One key barrier to curative therapies for HIV is the limited understanding of HIV persistence. HIV provirus integration sites (ISs) within are common, and almost all sites mapped to date are located upstream of the start codon in the same transcriptional orientation as the gene. These unique features suggest the possibility of insertional mutagenesis at this location.
View Article and Find Full Text PDF