Publications by authors named "Hanjing Meng"
Article Synopsis
- Cancer cells reprogram their metabolism, and a specific type of protein modification called malonylation is linked to this process and cancer growth, though its role is not fully understood.
- Research on hepatocellular carcinoma (HCC) showed reduced levels of malonyl-CoA and a general decline in protein malonylation, but increased malonylation of the protein nucleolin (NCL) was found in HCC samples.
- NCL's malonylation encourages its movement in the cell, allowing it to bind to AKT mRNA and enhance AKT production, which is crucial for HCC cell proliferation; reducing AKT levels effectively slowed down the growth of these cancer cells.
