Publications by authors named "Hanjing Li"

To investigate the influence of the fractured rock-concrete interface on the mechanical response of the rock mass and engineering, the mechanical properties and energy evolution of granite-concrete composite specimens with 16 different fracture inclinations were examined through uniaxial compression particle flow simulation. The results show that when the relative area is constant, the larger the fracture dip angle is, the compressive strength of the composite body presents a similar "peak" type change; the dip angle appears to have the maximum value at 60 o and 90o and the minimum value at 0 o and 30 o, while the peak elastic modulus presents a "waterfall" type change, and the maximum value appears at 90o. The crack types were classified as shear cracks, tensile cracks, secondary shear cracks, secondary tensile cracks, shear-dominated mixed cracks, and tension-dominated mixed cracks.

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Herein, a palladium-catalyzed cross-coupling cascade cyclization of alkene-tethered indoles and ()-β-chlorovinyl ketones, providing access to various furan-bearing indolo[2,1-]isoquinolines, is reported. The reaction enables the rapid construction of one C-O bond and two C-C bonds to form bis-heterocycles. Furthermore, these furan-bearing indolo[2,1-]isoquinolines exhibited certain antifungal activity .

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Neonatal mammalian hearts are capable of regenerating by inducing cardiomyocyte proliferation after injury. However, this regenerative capability in adult mammalian hearts almost disappears. Extracellular vesicles (EVs) have been shown to play vital cardioprotective roles in heart repair.

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The articular cartilage is characterized by its gradient hierarchical structure, which exhibits excellent lubrication and robust load-bearing properties. However, its inherent difficulty in self-repair after damage presents numerous formidable challenges for cartilage repair. Inspired by the unique structure of articular cartilage, a biomimetic bilayer hydrogel composed of PAM (polyacrylamide) and PAM/SA (sodium alginate) is prepared using a two-stepswelling method.

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Article Synopsis
  • Hydroxyapatite nanowires (HAW) improve cell survival in spheroids by providing material exchange channels, reducing core necrosis and enhancing biological activity.
  • HAW was synthesized and introduced to osteoblast precursor cells to create 3D composite spheroids with increased osteogenic differentiation capacity.
  • The study suggests that HAW-bone cell composite spheroids could serve as valuable components in 3D bioprinting for creating complex tissues and organoids.
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Objectives: Helicobacter pylori () is a type of bacteria that infects the stomach lining, and it is a major cause of chronic gastritis (CG). infection can influence the composition of the gastric microbiota. Additionally, alterations in the gut microbiome have been associated with various health conditions, including gastrointestinal disorders.

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Mammalian heart is capable to regenerate almost completely early after birth through endogenous cardiomyocyte proliferation. However, this regenerative capacity diminishes gradually with growth and is nearly lost in adulthood. Cannabidiol (CBD) is a major component of cannabis and has various biological activities to regulate oxidative stress, fibrosis, inflammation, and cell death.

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Background: Studies showed that development of gut microbial dysbiosis has a close association with type 2 diabetes (T2D). It is not yet clear if there is a causal relationship between gut microbiota and T2D.

Methods: The data collected from the published genome-wide association studies (GWASs) on gut microbiota and T2D were analyzed.

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Digestion and absorption of old cuticles during insect molting are necessary for new cuticle formation, during which complicated enzyme catalysis is essential. To date, a few carboxypeptidases, aminopeptidases and serine proteases (mostly trypsins) connected with cuticle digestion, zymogen activation and histological differentiation during the ecdysis of lepidopteran, dipteran and hymenopteran insects have been identified. However, little is known about these proteins in hemimetabolous insects.

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Mammalian cardiomyocytes (CMs) maintain a low capacity for self-renewal in adulthood, therefore the induction of CMs cycle re-entry is an important approach to promote myocardial repair after injury. Recently, photobiomodulation (PBM) has been used to manipulate physiological activities of various tissues and organs by non-invasive means. Here, we demonstrate that conditioned PBM using light-emitting diodes with a wavelength of 630 nm (LED-Red) was capable of promoting the proliferation of neonatal CMs.

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Background: RNA interference (RNAi) has potential as a new strategy for pest control. However, the current overemphasis on the control of a single pest increased control costs. The aim of this study was to find a green method of controlling several pests without affecting the natural enemies with a single target gene.

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Photobiomodulation (PBM) has emerged as an alternative therapy involved in modulating a variety of biological effects. In this study, we verified whether PBM can affect cardiac physiological activity in mice through noninvasive irradiation using light-emitting diodes at a wavelength of 630 nm (LED-Red). We found that the PBM involved in regulating the repair of injured myocardium is wavelength-limited.

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The brown planthopper () is a monophagous pest of rice (), which threatens food security around the world. Insect Heat shock proteins 70 kDa (Hsp70s) play a key role in insect growth and development, however, if they also modulate the plant physiological processes is still unclear. In this study, we identified the Heat shock 70 kDa protein cognate 3 (NlHSC70-3) of BPH from compared protein profiles of Nipponbare tissues after BPH infestation via LC/MS.

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The mechanism of sex determination remains poorly understood in hemimetabolous insects. Here, in the brown planthopper (BPH), , a hemipteran rice pest, we identified a feminizing switch or a () that encodes a serine/arginine-rich protein. Knockdown of in female nymphs resulted in masculinization of both the somatic morphology and splicing.

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Insects harbor a wide variety of symbiotic microorganisms that are capable of regulating host health and promoting host adaptation to their environment and food sources. However, there is little knowledge concerning the mechanisms that maintain the microbial community homeostasis within insects. In this study, we found that the () gene played an essential role in maintaining microbial homeostasis in the brown planthopper (BPH), .

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Aims: N6-Methyladenosine (mA), one of the important epigenitic modifications, is very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in various diseases. However, the role of mA modification in heart regeneration after injury remains unclear. The study was conducted to investigate whether targeting methyltransferase-like 3 (METTL3) could replenish the loss of cardiomyocytes (CMs) and improve cardiac function after myocardial infarction (MI).

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Objective: To determine the efficacy of acupuncture around the greater tuberosity of the femur (AGTF) combined with acupuncture at Xuehai acupoint for postoperative pain in elderly patients with intertrochanteric fracture.

Methods: A total of 97 elderly patients with intertrochanteric fracture treated by proximal femoral nail antirotation (PFNA) were enrolled and randomly assigned into an observation group (Obs group, n=48) and a control group (Con group, n=49). The Obs group was treated by aspirin and AGTF combined with acupuncture at Xuehai acupoint for analgesia, while the Con group was treated by aspirin alone for analgesia.

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(), a gene involved in the sex-determining cascade of , works in concert with the female-specific product of () at the end of the hierarchy to implement the sex-specific differentiation of sexually dimorphic characters in female individuals. In this study, the homolog was identified in the brown planthopper (BPH), , which contained two splice variants expressed in both female and male insects. We found that played a vital role in the early nymphal development of BPH, showing an accumulated effect.

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Objective: To compare the difference of therapeutic efficacy of electroacupuncture (EA) stimulation of abdominal acupoints and limb acupoints in the treatment of acute pancreatitis (AP), so as to provide a reference for EA treatment of AP.

Methods: A total of 60 patients with AP were equally and randomly divided into abdominal acupoint group and limb acupoint group. On the basis of retention enema of Chaiqin Chengqi Decoction (containing , etc.

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Pollen development metabolomics. Developing pollen is among the plant structures most sensitive to high temperatures, and a decrease in pollen viability is often associated with an alteration of metabolite content. Most of the metabolic studies of pollen have focused on a specific group of compounds, which limits the identification of physiologically important metabolites.

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Chronic liver disease is one of the most common diseases that threaten human health. Effective treatment is still lacking in western medicine. Semen Persicae (Taoren) and Flos Carthami (Honghua) are known to relieve acute hepatic injury and inflammation, improve microcirculation, and reduce tissue fiber.

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Plants defend themselves against potential pathogens via the recognition of pathogen-associated molecular patterns (PAMPs). However, the molecular mechanisms underlying this PAMP-triggered immunity (PTI) are largely unknown. In this study, we show that tomato HP1/DDB1, coding for a key component of the CUL4-based ubiquitin E3 ligase complex, is required for resistance to Agrobacterium tumefaciens.

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