Medication-related osteonecrosis of the jaw: a retrospective single center study of recurrence-related factors after surgical treatment.

Objectives: To provide an overview of the features of patients with medication-related osteonecrosis of the jaw (MRONJ) and explore recurrence-related factors after surgery.

Materials And Methods: All pathological records of patients diagnosed with osteonecrosis or osteomyelitis of the jaw were reviewed. Only patients who had a history of use of medication related to bone turnover were included.

Single versus dual venous anastomosis in radial forearm free flaps in head and neck reconstruction.

A retrospective cohort study of 253 radial forearm free flap (RFFF) procedures in head and neck reconstruction performed in our department between 2005 and 2018 was reviewed. In order to explore the effects between single and dual anastomoses, we applied Fisher's exact test for statistical analysis. Although no flap failure was identified, more venous compromises were observed in single anastomosis group (5/80 vs.

Abnormal downregulation of 10-formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway.

Background: 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) is a major folate enzyme, which is usually underexpressed in malignant tumors and competes with tumors for the same folate substrate. However, the specific role and mechanisms of ALDH1L1 in oral squamous cell carcinoma (OSCC) remainsobscure.

Methods: The expression level of ALDH1L1 in paired OSCC tissues and adjacent noncancerous tissues were detected by quantitative realtime PCR, Western blot and immunohistochemistry.