Automated Actuation of Biodegradable and Self-Fluorescent Chlorella Swarms Using Magnetic Tweezers.

Magnetic microrobot swarms have broad application prospects in human-targeted therapy. However, the automated assembly and actuation of functional large-volume swarms is a challenging topic. Chlorella with self-fluorescence and biodegradability is used in this paper as a template to prepare magnetic Chlorella-based microrobots through magnetron sputtering.

Optical tweezer-assisted cell pairing and fusion for somatic cell nuclear transfer within an open microchannel.

Somatic cell nuclear transfer (SCNT), referred to as somatic cell cloning, is a pivotal biotechnological technique utilized across various applications. Although robotic SCNT is currently available, the subsequent oocyte electrical activation/reconstructed embryo electrofusion is still manually completed by skilled operators, presenting challenges in efficient manipulation due to the uncontrollable positioning of the reconstructed embryo. This study introduces a robotic SCNT-electrofusion system to enable high-precision batch SCNT cloning.

Illumination-adjustable photoacoustic and harmonic ultrasound for tracking magnetically driven microrobots.

The development of microrobots for biomedical applications has enabled tasks such as targeted drug delivery, minimally invasive surgeries, and precise diagnostics. However, effective in vivo navigation and control remain challenging due to their small size and complex body environment. Photoacoustic (PA) and ultrasound (US) imaging techniques, which offer high contrast, high resolution, and deep tissue penetration, are integrated to enhance microrobot visualization and tracking.

Serotonin and dopamine depletion in distinct brain regions may cause anxiety in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice as a model of early Parkinson's disease.

In this study, we aimed to evaluate the association of early anxious behavior with serotonin, dopamine, and their metabolites in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson's disease. Forty C57BL/6 male mice were randomly divided into the control group (n = 20) and the model group (n = 20). Mice in the model group were injected intraperitoneally with MPTP.

[Effects of chronic hypoxic hypercapnia on spatial learning-memory and expression of NMDAR1 in rats].

Aim: To explore the effect of chronic hypoxic hypercapnia on learning-memory and the possible mechanisms involved.

Methods: Fifty-eight male SD rats were randomly divided into three groups: Normal control group (NC, n=18), 2-week (2HH, n=18), and 4-week hypoxic hypercapnia (4HH, n=20) group. The rats, spatial learning-memory tasks were assessed by the Morris water maze.

A clinical study of eosinophilic meningoencephalitis caused by angiostrongyliasis.

Objective: To improve the clinician's awareness of angiostrongyliasis.

Methods: The clinical and laboratory data as well as the epidemiological information concerning 18 patients with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis were analyzed.

Results: All patients had a history of eating raw fresh water snail (Ampularium canaliculatus) before the onset of the disease.