Exploring structure-directed immunogenic cytotoxicity of arginine-rich peptides for cytolysis-induced immunotherapy of cancer.

The same cells can die with varied immunological consequences. For the purpose of cancer therapy, stronger immunogenic death of cancer cells is considered favorable. Membrane disruptive peptides are cytotoxic agents with tunable structures capable of not just killing heterogeneous cancer cells, but also inducing immunogenic death.

Draw-tower-grating-based Fabry-Perot interferometers for simultaneous measurements of temperature and salinity.

In this paper, a fiber optic sensor with draw-tower-grating (DTG)-based Fabry-Perot interferometers (FPIs) are proposed to measure the temperature and salinity of seawater simultaneously. The sensing structure utilizes DTG as the reflector, and two adjacent gratings can be cascaded to compose an FPI. By employing moisture-sensitive materials to the surface of the optical fiber, the variation in salinity can be measured by the axial strain applied by the coating on the sensing optical fiber.

Deep Integration of Fiber-Optic Communication and Sensing Systems Using Forward-Transmission Distributed Vibration Sensing and on-off Keying.

The deep integration of communication and sensing technology in fiber-optic systems has been highly sought after in recent years, with the aim of rapid and cost-effective large-scale upgrading of existing communication cables in order to monitor ocean activities. As a proof-of-concept demonstration, a high-degree of compatibility was shown between forward-transmission distributed fiber-optic vibration sensing and an on-off keying (OOK)-based communication system. This type of deep integration allows distributed sensing to utilize the optical fiber communication cable, wavelength channel, optical signal and demodulation receiver.

Bulk-RNA and single-nuclei RNA seq analyses reveal the role of lactate metabolism-related genes in Alzheimer's disease.

Dysfunctional lactate metabolism in the brain has been implicated in neuroinflammation, Aβ deposition, and cell disturbance, all of which play a significant role in the pathogenesis of Alzheimer's disease (AD). In this study, we aimed to investigate the lactate metabolism-related genes (LMRGs) in AD via an integrated bulk RNA and single-nuclei RNA sequencing (snRNA-seq) analysis, with a specific focus on microglia. We obtained 26 HC and 24 AD snRNA-seq samples originated from human prefrontal cortex in Gene Expression Omnibus (GEO) database and collected 873 LMRGs from three databases, namely MSigDB, The Human Protein Atlas and GeneCards.

Automatic diagnosis of pediatric supracondylar humerus fractures using radiomics-based machine learning.

The aim of this study was to construct a classification model for the automatic diagnosis of pediatric supracondylar humerus fractures using radiomics-based machine learning. We retrospectively collected elbow joint Radiographs of children aged 3 to 14 years and manually delineated regions of interest (ROI) using ITK-SNAP. Radiomics features were extracted using pyradiomics, a python-based feature extraction tool.

Successful anesthesia management with inhalation anesthesia in Rosai-Dorfman disease: a case report.

Rosai-Dorfman disease (RDD) is a rare, benign, non-Langerhans cell histiocytic proliferative disease. RDD with central nervous system involvement is extremely rare. Surgical excision is generally regarded as the appropriate treatment of choice for this disease, especially when the lesion causes neurological compression.

Albumin pre-opsonized membrane-active iPep nanomedicine potentiates chemo to immunotherapy of cancer.

Chemotherapy-conjugated immunotherapy in clinical oncology conceptually resembles the combined effects of cytoreduction and immunostimulation in membrane targeted cell killings mediated by pore-forming proteins or host defense peptides. Of the similar concept, targeting cancer cell membrane using membrane active peptides is a hopeful therapeutic modality but had long been hindered from in vivo application. Here we report an enabling strategy of pre-opsonizing a membrane penetrating Ir-complexed octa-arginine peptide (iPep) with serum albumin via intrinsic amphipathicity-driven bimodal interactions into nanoparticles (NP).

Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing.

Objective: Astrocytes constitute approximately 30% of cells in gliomas and play important roles in synapse construction and survival. Recently, JAK/STAT pathway activation associated with a new type of astrocyte was reported. However, the implications of these tumor-associated reactive astrocytes (TARAs) in glioma are not known.

Ronidazole Is a Superior Prodrug to Metronidazole for Nitroreductase-Mediated Hepatocytes Ablation in Zebrafish Larvae.

The liver plays a very important role in physiological processes of the human body. Liver regeneration has developed into an important area of study in liver disease. The Mtz (metronidazole)/NTR (nitroreductase)-mediated cell ablation system has been widely used to study the processes and mechanisms of liver injury and regeneration.

A High-Sensitivity Dual-Axis Accelerometer with Two FP Cavities Assembled on Single Optical Fiber.

In this paper, a dual-axis Fabry-Pérot (FP) accelerometer assembled on single optical fiber is proposed. The sensor is equipped with a special beam-splitting prism to split the light into two perpendicular directions (the X- and Y-axes); the prism surface coated with semi-permeable film and the reflective sheet on the corresponding Be-Cu vibration-sensitive spring form two sets of FP cavities of different sizes. When the Be-Cu spring with a proof mass (PM) is subjected to the vibration signal, the cavity length of the corresponding FP cavity is changed and the interference signal returns to the collimator through the original path of the prism.

Pretreatment of Ultra-Weak Fiber Bragg Grating Hydrophone Array Based on Cubic Spline Interpolation Using Intensity Compensation.

The demodulation algorithm based on 3 × 3 coupler in a fiber-optic hydrophone array has gained extensive attention in recent years. The traditional method uses a circulator to construct the normal path-match interferometry; however, the problem of increasing the asymmetry of the three-way signal to be demodulated is easily overlooked. To provide a solution, we report a pretreatment method for hydrophone array based on 3 × 3 coupler demodulation.

Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs.

Endothelial progenitor cells (EPCs) are reduced in number and impaired in function in diabetic patients. Whether and how Nrf2 regulates the function of diabetic EPCs remains unclear. In this study, we found that the expression of Nrf2 and its downstream genes were decreased in EPCs from both diabetic patients and db/db mice.

Long Short-Term Memory Neural Network with Transfer Learning and Ensemble Learning for Remaining Useful Life Prediction.

Prediction of remaining useful life (RUL) is greatly significant for improving the safety and reliability of manufacturing equipment. However, in real industry, it is difficult for RUL prediction models trained on a small sample of faults to obtain satisfactory accuracy. To overcome this drawback, this paper presents a long short-term memory (LSTM) neural network with transfer learning and ensemble learning and combines it with an unsupervised health indicator (HI) construction method for remaining-useful-life prediction.

Vaping Flavors and Flavor Representation: A Test of Youth Risk Perceptions, Novelty Perceptions, and Susceptibility.

Introduction: Whether novelty-flavored vaping devices should be available in the marketplace has been a hotly contested debate. From one perspective, the variety of different flavors, such as fruit and mint, may help adult cigarette smokers who are seeking to switch to reduced-harm nicotine products. However, these flavors are also wildly popular among youth, creating concerns about new nicotine product use among minors.

Empagliflozin Ameliorates Diabetic Cardiomyopathy via Attenuating Oxidative Stress and Improving Mitochondrial Function.

Diabetic cardiomyopathy (DCM) is considered to be a critical contributor to the development of heart failure. Empagliflozin (EMPA), a sodium-glucose cotransporter 2 inhibitor, has been shown to prevent cardiovascular events and reduce the incidence of heart failure in randomized clinical trials. However, the mechanism of how EMPA prevents DCM is poorly understood.

High-Resolution Optical Fiber Temperature Sensor Based on Draw Tower Grating Array.

Ocean temperature monitoring is of great significance to marine fishing, aquaculture, and marine operations. Traditional electric sensors lack the potential to multiplex several sensors, and may suffer from electromagnetic interference. Meanwhile, fiber Bragg grating-based sensors have the advantages of high sensitivity, possibility for large-scale multiplexing, and immunity to electromagnetic interference.

Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma.

The most prevalent malignant central nervous system (CNS) cancer is glioblastoma multiforme (GBM). PLKs (polo-like kinases) are a kind of serine-threonine kinase that modulate DNA replication, mitosis, and stress responses. PLKs in GBM need to be better studied and examined in terms of their expression, function, along with prognostic significance.

Comprehensive analysis of the LncRNAs, MiRNAs, and MRNAs acting within the competing endogenous RNA network of LGG.

Messenger RNA (mRNA) and long noncoding RNA (lncRNA) targets interact via competitive microRNA (miRNA) binding. However, the roles of cancer-specific lncRNAs in the competing endogenous RNA (ceRNA) networks of low-grade glioma (LGG) remain unclear. This study obtained RNA sequencing data for normal solid tissue and LGG primary tumour tissue from The Cancer Genome Atlas database.