Publications by authors named "Haniel Araujo"
Article Synopsis
- Dual immune checkpoint blockade (ICB) using CTLA4 and PD-(L)1 inhibitors shows improved anti-tumor effectiveness and immune toxicity compared to PD-(L)1 inhibitors alone in advanced non-small-cell lung cancer (NSCLC) patients.
- Patients with mutations in STK11 and/or KEAP1 genes benefit more from the combination treatment compared to those receiving only PD-(L)1 inhibitors, as shown in the POSEIDON trial.
- The loss of KEAP1 serves as a strong predictor for the success of dual ICB, as it leads to a more favorable outcome by changing the tumor's immune environment to better engage CD4 and CD8 T cells for anti-tumor activity. *
Article Synopsis
- The study investigates the effectiveness of the RAS(ON) multiselective inhibitor RMC-7977 against KRASG12C-mutant non-small cell lung cancer (NSCLC) that shows resistance to traditional RASG12C inhibitors.
- It found that targeting RASGTP, either alone or alongside active RASG12C, leads to improved anti-tumor activity in various mouse models, indicating a more effective treatment strategy.
- Additionally, the research highlights a specific transcriptional program related to mucinous features in tumors, which may hinder the effectiveness of therapies like sotorasib or adagrasib in patients, presenting new insights for personalized treatment approaches.
Article Synopsis
- A study analyzed 424 patients with KRASG12C-mutant non-small cell lung cancer (NSCLC) and identified key genomic alterations (in KEAP1, SMARCA4, and CDKN2A) that lead to worse outcomes with KRASG12C inhibitors (KRASG12Ci).
- These alterations allowed researchers to classify patients into different prognostic groups, indicating nearly 50% of those who experienced early disease progression.
- The research suggests potential pathways not only associated with poor response (like PI3K/AKT/MTOR) but also hints that certain DNA damage response issues might improve KRASG12Ci effectiveness, paving the way for personalized treatment strategies.
Context And Objective: Cerebrovascular disease is one of the most important causes of death and disability worldwide. The patient's inability to identify the warning signs of stroke substantially delays the search for emergency services, which is related directly to a worse outcome. Thus, during the 2011 Stroke Campaign in Brazil, a survey was conducted to identify the lay population's knowledge with regard to the recognition, treatment, and prevention of stroke.
View Article and Find Full Text PDFIntroduction: The assessment of cortical excitability (CE) measurements has been increasingly used in neuropsychiatric research. However, there is scant information on the normative values of these measurements, as well as the possible effect of hemisphere laterality, gender and age on these variables.
Objectives: To obtain normative data for CE measurements by transcranial magnetic stimulation, to assess inter-/intra-investigator variability and the influence of sex, age and oral contraception use.
Whole-vessel remodeling critically determines lumen caliber in vascular (patho)physiology, and it is reportedly redox-dependent. We hypothesized that the cell-surface pool of the endoplasmic reticulum redox chaperone protein disulfide isomerase-A1 (peri/epicellular=pecPDI), which is known to support thrombosis, also regulates disease-associated vascular architecture. In human coronary atheromas, PDI expression inversely correlated with constrictive remodeling and plaque stability.
View Article and Find Full Text PDFAims: Superficial erosion of atheromata causes many acute coronary syndromes, but arises from unknown mechanisms. This study tested the hypothesis that Toll-like receptor-2 (TLR2) activation contributes to endothelial apoptosis and denudation and thus contributes to the pathogenesis of superficial erosion.
Methods And Results: Toll-like receptor-2 and neutrophils localized at sites of superficially eroded human plaques.
Objective: To review the literature on the analgesic effects of repetitive transcranial magnetic stimulation (rTMS) in chronic pain according to different pain syndromes and stimulation parameters.
Data Sources: Publications on rTMS and chronic pain were searched in PubMed and Google Scholar using the following key words: chronic pain, analgesia, transcranial magnetic stimulation, neuropathic pain, fibromyalgia, and complex regional pain syndrome.
Study Selection: This review only included double-blind, controlled studies with >10 participants in each arm that were published from 1996 to 2014 and written in English.
Article Synopsis
- The study investigates the role of interstitial collagenases, specifically MMP-13 and MMP-8, in the development and characteristics of atherosclerotic plaques in mice.
- Mice with specific gene deletions related to MMPs were fed a high-cholesterol diet, revealing that those lacking MMP-13 exhibited significantly reduced collagen degradation in lesions.
- The findings suggest MMP-13 is the primary collagenase involved in plaque structure, indicating potential clinical implications for targeting this enzyme in future treatments, although the results may not directly apply to human cases.