Optimization of a centrifugal blood pump designed using an industrial method through experimental and numerical study.

With improved treatment of coronary artery disease, more patients are surviving until heart failure occurs. This leads to an increase in patients needing devices for struggling with heart failure. Ventricular assist devices are known as the mainstay of these devices.

Analysis of the Adherent Cell Response to the Substrate Stiffness Using Tensegrity.

Cell's shape is dependent on the cytoskeleton mechanical properties. Hybrid models were developed that combine the discrete structure for the cytoskeleton and continuum parts for other cell organelles. Tensegrity-based structures that consist of tensile and compression elements are useful models to understand the cytoskeleton mechanical behavior.

Multi-scale model of lumen formation via inverse membrane blebbing mechanism during sprouting angiogenesis process.

Cancer is one of the leading causes of mortality and morbidity among people worldwide. Cancer appears as solid tumors in many cases. Angiogenesis is the growth of blood vessels from the existing vasculature and is one of the imperative processes in tumor growth.

Design of an aortic polymeric valve with asymmetric leaflets and evaluation of its performance by finite element method.

Background: The geometry of leaflets plays a significant role in prosthetic valves' (PVs) performance. Typically, natural aortic valves have three unequal leaflets, which differ in size. The present study aims to design an asymmetric tri-leaflet polymeric valve with one large and two small leaflets based on commissure lengths and leaflet eccentricities.

Investigation the effect of geometry and position of polymeric heart valves on hemodynamic with fluid-structure interaction numerical method.

Computational modeling and numerical simulation of heart valve dynamics incorporating both fluid dynamics and valve structural replications has been challenging. In this study, we developed a double-coupled fluid-structure interaction (FSI) model using arbitrary lagrangian eulerian(ALE) and steered adaptive mesh(SAM). So we were looking to simulate transcatheter aortic valve (TAV) hemodynamic performance throughout entire cardiac cycles [1].

Numerical study of hemodynamics in a complete coronary bypass with venous and arterial grafts and different degrees of stenosis.

Cardiovascular diseases are among the leading causes of death in the world. The coronary blockage is one of most common types of these diseases that in the majority of cases has been treated by bypass surgery. In the bypass surgery, a graft is implemented to alter the blocked coronary and allow the blood supply process.

Local hemodynamic analysis of the C-Pulse Device by 3D fluid-structure interaction simulation.

C-Pulse is a new, nonblood contacting device based on the concept of counter-pulsation that is designed for long-term implantation. However, there is a lack of comprehensive investigation of the pressure and velocity fields under the action of C-Pulse. In this paper, we aim to conduct a numerical simulation of the underlying mechanism of the device in order to analyze its performance and related undesirable issues.

Personalized image-based tumor growth prediction in a convection-diffusion-reaction model.

Inter-individual heterogeneity of tumors leads to non-effectiveness of unique therapy plans. This issue has caused a growing interest in the field of personalized medicine and its application in tumor growth evaluation. Accordingly, in this paper, a framework of personalized medicine is presented for growth prediction of brain glioma tumors.

Simulating glioblastoma growth consisting both visible and invisible parts of the tumor using a diffusion-reaction model followed by resection and radiotherapy.

Glioblastoma is known to be among one of the deadliest brain tumors in the world today. There have been major improvements in the detection of cancerous cells in the twenty-first century. However, the threshold of detection of these cancerous cells varies in different scanning techniques such as magnetic resonance imaging (MRI) and computed tomography (CT).

Numerical simulation of osteocyte cell in response to directional mechanical loadings and mechanotransduction analysis: Considering lacunar-canalicular interstitial fluid flow.

The osteocyte cell is a bone cell that also functions as a bone mechanosensor. In this work, a three-dimensional (3D) fluid-structure interaction (FSI) model of an osteocyte cell under different mechanical loading conditions was used to obtain a better understanding of osteocyte cell behavior under different physiological conditions. In the current study, both fluid and solid parts of osteocyte cell were considered in order to allow for more accurate results.

Computational fluid dynamics-based study of possibility of generating pulsatile blood flow via a continuous-flow VAD.

Until recent years, it was almost beyond remedy to save the life of end-stage heart failure patients without considering a heart transplant. This is while the need for healthy organs has always far exceeded donations. However, the evolution of VAD technology has certainly changed the management of these patients.

A comparative study of thermal effects of 3 types of laser in eye: 3D simulation with bioheat equation.

The application of laser in ophthalmology and eye surgery is so widespread that hardly can anyone deny its importance. On the other hand, since the human eye is an organ susceptible to external factors such as heat waves, laser radiation rapidly increases the temperature of the eye and therefore the study of temperature distribution inside the eye under laser irradiation is crucial; but the use of experimental and invasive methods for measuring the temperature inside the eye is typically high-risk and hazardous. In this paper, using the three-dimensional finite element method, the distribution of heat transfer inside the eye under transient condition was studied through three different lasers named Nd:Yag, Nd:Yap and ArF.

Numerical investigation of three patterns of motion in an electromagnetic pulsatile VAD.

Hemolysis and thrombus formation which are critical concerns in designing a long-term implantable ventricular assist device (VAD) have impeded the widespread use of VADs. In this study, thus, the three-dimensional fluid domain of blood flow in a small bichamber positive displacement VAD (25 ml) with a magnetically levitated moving pusher plate was simulated by the means of a finite element package called ADINA. To optimize the function of the pump for minimizing shear stress induced blood damage, three different driver patterns (linear, sinusoidal, and Guyton's pulse) were investigated.

A new design and computational fluid dynamics study of an implantable axial blood pump.

Considering small thoracic space, using implantable ventricular assist device requires reduction in a pump size. Among many available blood pumps, axial blood pumps have attracted greatly because of their small size. In this article, a new miniature axial blood pump has been designed and studied which can be easily implanted in the human body.

Comparison of blood flow velocity through the internal carotid artery based on Doppler ultrasound and numerical simulation.

Doppler ultrasound is a usual non-invasive method to estimate the stenosis percentage in large arteries such as carotid by measuring maximum velocity of blood flow. Based on clinical investigations, because of vessel wall motions, Doppler positioning and angle correction, some errors can arise in Doppler results which lead to incorrect diagnosis. The aim of this study was to compare the results of Doppler test and the numerical simulation of blood flow in the same case.