Publications by authors named "Hania Abdelhafez"
Article Synopsis
- Gene therapies like TNNT2-4Fpolycistronic-NIL have shown promise in treating subacute ischaemic heart failure (IHF) by inducing cardiomyocyte (CM) cell cycle re-entry but need testing in chronic IHF settings for broader clinical relevance.
- In the study, rats with induced chronic IHF were treated with TNNT2-4Fpolycistronic-NIL, which led to reduced scar size and improved left ventricular function over four months, though it didn't prevent LV dilation associated with chronic IHF.
- The findings suggest that this gene therapy effectively promotes CM regeneration in chronic IHF, highlighting potential new treatment avenues for this widespread condition.
Background And Purpose: Myocardial infarction (MI) is the leading cause of mortality globally due in part to the limited ability of cardiomyocytes (CMs) to regenerate. Recently, we demonstrated that overexpression of four-cell cycle factors, CDK1, CDK4, cyclin B1 and cyclin D1 (4F), induced cell division in ~20% of the post-mitotic CMs overexpressed 4F. The current study aims to identify a small molecule that augments 4F-induced CM cycle induction.
View Article and Find Full Text PDF