Publications by authors named "Hani M Abdelsalam"
Article Synopsis
- - The study investigates the effects of platelet-rich plasma (PRP) and exosome injections on kidney and brain tissue following renal ischemia/reperfusion (I/R) injury, which disrupts the blood-brain barrier and elevates toxins leading to uremic encephalopathy.
- - Results show that rats treated with PRP and exosomes exhibited improved kidney function, increased brain GABA levels, decreased glutamate, and better histological outcomes, compared to those that only experienced I/R injury.
- - Additionally, the treatments led to reduced oxidative stress and inflammation markers in renal tissues, as well as significant restoration of damaged brain cells, indicating their potential as therapeutic options for kidney-related brain injuries.
Background: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian brain and is a non-proteinogenic amino acid. Doxorubcin (DOX) or adriamycin is one of the most potent chemotherapy drugs for breast cancer.
Purpose: This study focused on diminishing the brain injury and neurotoxicity of doxorubicin (DOX) by GABA administration.
Background: Cardiorenal crosstalk has gained growing scientific curiosity recently. Clinical observations have approved that heart and kidney performances are intimately interrelated; acute or chronic dysfunction of either is inevitably mirrored on the other. This coexistence usually has the poor prognosis and worsened outcome.
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