A lanthanide metal organic frameworks ratiometric fluorescence sensor for visual detection of anthrax biomarker.

A novel dual-emission fluorescence probe, Eu-TDA-DHTP, was developed based on a ratiometric fluorescence-organic frameworks utilizing Eu, 2,5-Thiophenedicarboxylic acid, and 2,5-dihydroxyterephthalic acid for the ratiometric and fluorescent visual sensing of the anthrax biomarker 2,6-pyridine dicarboxylic acid (DPA). The experiments demonstrated that this material can effectively enhance dual emission for DPA detection, enabling clear visualization. The limit of detection for DPA detection using Eu-TDA-DHTP is 1.

Curcumin's protective role against fluoride-induced bone damage: Implications for pullet pathology and skeletal biomechanics.

This study aimed to investigate the effects of dietary fluoride (F) and curcumin (Cur) supplementation on the tibial biomechanical performance, histopathology, and behavior of pullets. Four dietary F levels (0, 400, 800, 1200 mg/kg) supplemented with CUR (0, 200 mg/kg) were used to create 8 experimental groups in Hyline Brown pullets. Behavioral study results showed that supplements of 1200 mg/kg F reduced the percentages of feeding, walking, standing, and preening behaviors while increasing the percentage of lying behavior (P < 0.

Effects of sulfonamide on water remediation by aquatic plants: Insight from toxicological responses.

Overuse of antibiotics such as sulfonamide (SA) has led to their excess existence in water environment, which would threaten water ecological security and human health. In this study, the resistance of three plants to SA was systematically studied. The relative growth rate (RGR) of Pistia stratiotes L.

Untargeted metabolomics unveils critical metabolic signatures in novel phenotypes of acute ischemic stroke.

This study aimed to identify metabolic footprints associated with distinct phenotypes of acute ischemic stroke (AIS) using untargeted metabolomics. We included 20 samples each from AIS phenotype A (n = 251), B (n = 213), and C (n = 43) groups, along with 20 age- and gender-matched healthy controls (HCs). Plasma metabolic profiles were analyzed using liquid chromatography-mass spectrometry (LC-MS).

Patient-derived tumor xenograft animal model of gastric cancer in precision chemotherapy.

This study aims to establish a patient-derived tumor xenograft (PDX) model for gastric cancer and apply it in pharmacodynamic studies for chemotherapeutic agents. So as to provide guidance for personalized treatment in gastric cancer patients. Fresh gastric cancer tissues were collected from surgical patients and transplanted into NOG mice to establish PDX model.

Predictive effect of modified frailty index on postoperative nausea and vomiting in thyroid cancer patients.

Postoperative nausea and vomiting (PONV) are common complications following thyroid cancer surgery, impacting patient well-being, prognosis, and potentially leading to severe complications. Frailty, a critical risk factor for postoperative complications, has not been thoroughly investigated concerning PONV in thyroid cancer patients. This study aimed to explore the correlation between frailty and PONV in thyroid cancer patients.

Intra-tumoral bacteria in head and neck cancer: holistic integrative insight.

Intra-tumoral bacteria are pivotal in the initiation and progression of head and neck squamous cell carcinoma (HNSCC), exerting a significant influence on tumor cell biology, immune responses, and the tumor microenvironment (TME). Different types and distribution of bacteria threaten the balance of metabolism and the immune environment of tumor cells. Taking advantage of this disrupted homeostasis, intra-tumoral bacteria stimulate the secretion of metabolites or influence specific immune cell types to produce inflammatory or chemokines, thereby influencing the anti-tumor immune response while regulating the level of inflammation and immunosuppression within the TME.

() infection in hospitalized adult patients in Cambodia.

Unlabelled: Despite high levels of global concern, little is known about the epidemiology of () infection (CDI) in Cambodia. This study aimed to identify the prevalence and risk factors for CDI, and molecular types of in hospitalized adults at Calmette Hospital, Phnom Penh, Cambodia. Stool samples were collected from 263 hospitalized adults between June and September 2022 and tested for using direct and enrichment cultures.

LNC159c Negatively Regulates Anthocyanin Biosynthesis via miR159c in Malus spectabilis Under Low Nitrogen.

Low-nitrogen (LN) conditions typically promote anthocyanin biosynthesis in plants. Although previous studies primarily explored structural genes and transcription factors involved in anthocyanin biosynthesis, the role of long noncoding RNAs (lncRNAs) in this process under LN conditions remains less understood. This study identified LNC159c as a potential regulator of anthocyanin biosynthesis, with its expression notably downregulated under LN conditions.

Association between weekend catch-up sleep and hypertension of the United States population from 2017 to 2020: a cross-sectional study.

Background: Hypertension is a prevalent cardiovascular risk factor that significantly contributes to morbidity and mortality worldwide. Previous studies have highlighted the role of inadequate sleep during weekdays in the development of hypertension. However, the potential mitigative effects of weekend catch-up sleep (WCS) on hypertension have been less explored.

Polyhydroxyalkanoate production during electroactive biofilm formation and stabilization in wetland microbial fuel cells for petroleum hydrocarbon bioconversion.

This study presented new insights into the sustainable conversion of total petroleum hydrocarbon (TPHC) into polyhydroxyalkanoates (PHAs) using wetland microbial fuel cells (WMFCs). The main innovations included the following two points: (1) The integration of bioelectricity generation with efficient PHA production further underscored the potential of electroactive biofilms as a sustainable platform for simultaneous TPHC biotransformation, bioelectricity recovery and PHA production. (2) The interactive dynamics of PHAs, metabolites, extracellular polymeric substances (EPS) and microorganisms during the formation and stabilization of electroactive biofilms provided novel insights into microbial strategies for carbon utilization.

Can digital governance stimulate green development? Evidence from the program of "pilot cities regarding information for public well-being" in China.

Digital governance is an important goal of government digital transformation, and the policy of "pilot cities regarding information for public well-being" in China is an important initiative to promote the reform of government governance system and realize green development. Based on the panel data of 282 cities in China from 2007 to 2020, this paper analyzes the mechanism and path of the impact of digital governance on green development using the program of "pilot cities regarding information for public well-being" as a quasi-natural experiment. The double-difference model and mediation effect model are utilized.

ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.

Anillin (ANLN) is a highly conserved protein involved in cytokinesis and cytoskeletal remodeling. This study investigates the role of ANLN in head and neck squamous cell carcinoma (HNSCC) progression and its impact on the tumor immune microenvironment, with a focus on the combination of ANLN silencing and anti-programmed cell death protein 1 (PD-1) therapy. Through and experiments, along with clinical specimen analysis, we discovered that silencing ANLN not only inhibits the malignant progression of HNSCC but also reduces the activation of the extracellular signal-regulated kinase-mitogen-activated protein kinase (ERK-MAPK) signaling pathway and decreases programmed death ligand-1 (PD-L1) expression.

Dielectric metasurface-assisted terahertz sensing: mechanism, fabrication, and multiscenario applications.

Terahertz (THz) technology has attracted significant global interest, particularly in sensing applications, due to its nonionizing feature and sensitivity to weak interactions. Recently, owing to the advantages of low optical loss and the capability to support both electric and magnetic high-quality factor (high-Q) resonances, dielectric metasurfaces have emerged as a powerful platform for multiscenario terahertz sensing applications. This review summarizes recent advancements in dielectric metasurface-assisted THz sensing.

Heterocyclic Assembly: An Underutilized Disconnection with Potential to Maximize High Fsp Chemical Space Exploration.

From a retrosynthetic standpoint, or heterocyclic cores are fundamental disconnections that chemists make. This manuscript highlights heterocycle synthesis as the strategic bond disconnection by leveraging ubiquitous building blocks, carboxylic acids and amines, for preparation of heterocyclic cores in a library-friendly format. This heterocyclic formation strategy allows medicinal chemists to access much wider chemical space, especially for analogs with higher Fsp vs state-of-the-art heterocycle functionalization methods.

"Frozen" Ionogels with High and Tunable Toughness for Soft Electronics.

As a promising material, ionogels have garnered increasing interest in various applications including flexible electronics and energy storage. However, most existing ionogels suffer from poor mechanical properties. Herein, an effective and universal strategy is reported to toughen ionogels by freezing the polymer network via network design.

Sensory quality and metabolite dynamics in an organic selenium-enriched milk fermented by Geotrichum candidum.

This study explores selenium enrichment of milk through microbial transformation, utilizing Geotrichum candidum LG-8, isolated from traditional dairy products. A combination of electronic tongue, electronic nose, HPLC-ICP-MS, and UHPLC-QTOF-MS were used to evaluate milk quality, organic selenium types, and various components. The milk retained a weakly acidic pH post-transformation, with a flavor profile rich in sour, sweet, and umami tastes.

Anterior lumbar discectomy and fusion: an effective technique in treating lumbar disc herniation-- a retrospective case study.

Objective: Lumbar disc herniation is a syndrome triggered by degenerative changes in the intervertebral disc. Based on the technique of ALIF, combining the concept of Anterior Cervical Discectomy and Fusion (ACDF), we summarized Anterior Lumbar Discectomy Fusion (ALDF) in our previous clinical experience. This study is to explore the clinical efficacy and safety of this method for treating lumbar disc herniation.

Metagenomic analysis reveal the phytoremediation effects of monocropping and intercropping of halophytes Halogeton glomeratus and Suaeda glauca in saline soil of Northwestern China.

Aims: Planting halophytes is a widely used method of phytoremediation for saline soils. The succulent halophytes Halogeton glomeratus and Suaeda glauca are widely used for remediation of saline soil in the arid region of Northwestern China. However, whether intercropping of H.

Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies.

Abnormal glucose metabolism inevitably disrupts normal neuronal function, a phenomenon widely observed in Alzheimer's disease (AD). Investigating the mechanisms of metabolic adaptation during disease progression has become a central focus of research. Considering that impaired glucose metabolism is closely related to decreased insulin signaling and insulin resistance, a new concept "type 3 diabetes mellitus (T3DM)" has been coined.

The effects of an unfamiliar experimenter on proactive and reactive control in children.

Cognitive control development across childhood is critical for later academic achievement. Despite recent advances in the comprehension of how the context influences cognitive control development, no study has ever addressed whether one of the most frequent contextual features of children's lives (i.e.