Hierarchically Porous Microgels with Interior Spiral Canals for High-Efficiency Delivery of Stem Cells in Wound Healing.

Chronic wound poses a serious risk to diabetic patients, primarily due to damaged skin microvasculature and prolonged inflammation at the wound site. Mesenchymal stem cell (MSC) therapy utilizing microgels as a cell delivery system has shown promise in promoting wound healing by enhancing cell viability and the secretion of bioactive factors. Retaining sufficient MSCs at injury sites is crucial for optimal therapeutic outcomes.

Bifunctional nanoprobe for simultaneous detection of intracellular reactive oxygen species and temperature in single cells.

Living cells can rapidly adjust their metabolic activities in response to external stimuli, leading to fluctuations in intracellular temperature and reactive oxygen species (ROS) levels. Monitoring these parameters is essential for understanding cellular metabolism, particularly during dynamic biological processes. In this study, we present a bifunctional nanoprobe capable of simultaneous measurement of ROS levels and temperature within single cells.

Light patterning semiconductor nanoparticles by modulating surface charges.

Optical patterning of colloidal particles is a scalable and cost-effective approach for creating multiscale functional structures. Existing methods often use high-intensity light sources and customized optical setups, making them less feasible for large-scale microfabrication processes. Here, we report an optical patterning method for semiconductor nanoparticles by light-triggered modulation of their surface charge.

The important role of ferroptosis in inflammatory bowel disease.

Ferroptosis is a type of regulated cell death that occurs due to the iron-dependent accumulation of lethal reactive oxygen species (ROS) from lipids. Ferroptosis is characterized by distinct morphological, biochemical, and genetic features that differentiate it from other regulated cell death (RCD) types, which include apoptosis, various necrosis types, and autophagy. Recent reports show that ferritin formation is correlated to many disorders, such as acute injury, infarction, inflammation, and cancer.

Molecular Mechanism Study of Dietary Fiber Lignin Intervention in Ulcerative Colitis through GPR37.

Lignin is dietary fiber from plant cell walls with multiple biological antioxidant and anti-inflammatory activities. However, whether lignin protects from ulcerative colitis (UC) and underlying mechanisms is unclear. Herein, UC mouse modeling was established with dextran sulfate sodium (DSS) and treatment with lignin for 1 week.

DNA methylation-mediated ROS production contributes to seed abortion in litchi.

Although there is increasing evidence suggesting that DNA methylation regulates seed development, the underlying mechanisms remain poorly understood. Therefore, we aimed to shed light on this by conducting whole-genome bisulfite sequencing using seeds from the large-seeded cultivar 'HZ' and the abortive-seeded cultivar 'NMC'. Our analysis revealed that the 'HZ' seeds exhibited a hypermethylation level compared to the 'NMC' seeds.

Sustainable cellobionic acid biosynthesis from starch via artificial in vitro synthetic enzymatic biosystem.

Cellobionic acid (CBA), a kind of aldobionic acid, offers potential applications in the fields of pharmaceutical, cosmetic, food, and chemical industry. To tackle the high cost of the substrate cellobiose in CBA production using quinoprotein glucose dehydrogenase, this study developed a coenzyme-free and phosphate-balanced in vitro synthetic enzymatic biosystem (ivSEBS) to enable the sustainable CBA synthesis from cost-effective starch in one-pot via the CBA-synthesis module and gluconic acid-supply module. The metabolic fluxes of this artificial biosystem were strengthened using design-build-test-analysis strategy, which involved exquisite pathway design, meticulous enzyme selection, module validation and integration, and optimization of the key enzyme dosage.

Polydopamine-Modified 2D Iron (II) Immobilized MnPS Nanosheets for Multimodal Imaging-Guided Cancer Synergistic Photothermal-Chemodynamic Therapy.

Manganese phosphosulphide (MnPS ), a newly emerged and promising member of the 2D metal phosphorus trichalcogenides (MPX ) family, has aroused abundant interest due to its unique physicochemical properties and applications in energy storage and conversion. However, its potential in the field of biomedicine, particularly as a nanotherapeutic platform for cancer therapy, has remained largely unexplored. Herein, a 2D "all-in-one" theranostic nanoplatform based on MnPS is designed and applied for imaging-guided synergistic photothermal-chemodynamic therapy.

Increased DNA methylation of the splicing regulator SR45 suppresses seed abortion in litchi.

The gene regulatory networks that govern seed development are complex, yet very little is known about the genes and processes that are controlled by DNA methylation. Here, we performed single-base resolution DNA methylome analysis and found that CHH methylation increased significantly throughout seed development in litchi. Based on the association analysis of differentially methylated regions and weighted gene co-expression network analysis (WGCNA), 46 genes were identified as essential DNA methylation-regulated candidate genes involved in litchi seed development, including LcSR45, a homolog of the serine/arginine-rich (SR) splicing regulator SR45.

FK866 inhibits colorectal cancer metastasis by reducing NAD levels in cancer-associated fibroblasts.

Background: Extraintestinal metastasis is the main therapeutic challenge for colorectal cancer, the third most common cancer worldwide. Various components of the tumor microenvironment, especially cancer-associated fibroblasts (CAFs), play important roles in tumor metastasis. NAMPT is often overexpressed in tumor tissues and is associated with poorer prognosis.

Moxidectin induces autophagy arrest in colorectal cancer.

Colorectal cancer (CRC) is a cancer with a high morbidity and mortality worldwide. Hence, developing new therapeutic drugs for CRC is very important. Moxidectin (MOX) has shown good anti-glioblastoma effect both in vitro and in vivo.

Niobium Diselenide Nanosheets: An Emerging Biodegradable Nanoplatform for Efficient Cancer Phototheranostics in the NIR-II Window.

As a prominent class of 2D transition metal dichalcogenides (TMDCs), niobium diselenide nanosheets (NbSe NSs) have garnered tremendous interest on account of promising applications pertaining to optoelectronics and energy storage. Although NbSe NSs have many unique advantages such as inherent biocompatibility and broad absorption in the NIR region, their biomedical applications have rarely been reported, especially as therapeutic agents for the second near-infrared (NIR-II) range. Herein, a biodegradable nanotherapeutic platform consisting of NbSe NSs is designed and demonstrated for NIR-II light-triggered photothermal therapy.

Sugar Transport, Metabolism and Signaling in Fruit Development of Sonn: A Review.

Sonn. is an important evergreen fruit crop cultivated in the tropical and subtropical regions. The edible portion of litchi fruit is the aril, which contains a high concentration of sucrose, glucose, and fructose.

Photochemical Activity of Black Phosphorus for Near-Infrared Light Controlled In Situ Biomineralization.

The photochemical activity of black phosphorus (BP) in near-infrared (NIR) light controlled in situ biomineralization is investigated. Owing to the excellent NIR absorption, irradiation with NIR light not only promotes degradation of BP into PO , but also enhances the chemical activity to accelerate the reaction between PO and Ca and promote in situ biomineralization. Mineralization of hydrogels is demonstrated by the preparation of BP incorporated hydrogel (BP@Hydrogel) which delivers greatly improved biomineralization performance under NIR illumination.

Biodegradable Bi O Se Quantum Dots for Photoacoustic Imaging-Guided Cancer Photothermal Therapy.

As new 2D layered nanomaterials, Bi O Se nanoplates have unique semiconducting properties that can benefit biomedical applications. Herein, a facile top-down approach for the synthesis of Bi O Se quantum dots (QDs) in a solution is described. The Bi O Se QDs with a size of 3.

Genome-wide identification and expression analysis of SWEET gene family in Litchi chinensis reveal the involvement of LcSWEET2a/3b in early seed development.

Background: SWEETs (Sugar Will Eventually be Exported transporters) function as sugar efflux transporters that perform diverse physiological functions, including phloem loading, nectar secretion, seed filling, and pathogen nutrition. The SWEET gene family has been identified and characterized in a number of plant species, but little is known about in Litchi chinensis, which is an important evergreen fruit crop.

Results: In this study, 16 LcSWEET genes were identified and nominated according to its homologous genes in Arabidopsis and grapevine.

Facile mass production of self-supported two-dimensional transition metal oxides for catalytic applications.

We report a novel metal-corrosion route beyond traditional top-down or bottom-up strategies for the mass production of 2D TMOs with a self-supported structure. The self-supported 2D CoO, a typical TMO, exhibits excellent electrocatalytic activity and stability in the oxygen evolution reaction surpassing those of commercial precious metal RuO catalysts at high currents.

Electrostatic Self-Assembly of TiCT MXene and Gold Nanorods as an Efficient Surface-Enhanced Raman Scattering Platform for Reliable and High-Sensitivity Determination of Organic Pollutants.

A reliable surface-enhanced Raman scattering (SERS) substrate composed of two-dimensional (2D) MXene (TiCT) nanosheets and gold nanorods (AuNRs) is designed and fabricated for sensitive detection of organic pollutants. The AuNRs are uniformly distributed on the surface of the 2D MXene nanosheets because of the strong electrostatic interactions, forming abundant SERS hot spots. The MXene/AuNR SERS substrate exhibits high sensitivity and excellent reproducibility in the determination of common organic dyes such as rhodamine 6G, crystal violet, and malachite green.

Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration.

A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability.

Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer.

Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR-induced sol-gel transition as well as good biodegradability and biocompatibility in vitro and in vivo.

Biodegradable near-infrared-photoresponsive shape memory implants based on black phosphorus nanofillers.

In this paper, we propose a new shape memory polymer (SMP) composite with excellent near-infrared (NIR)-photoresponsive shape memory performance and biodegradability. The composite is fabricated by using piperazine-based polyurethane (PU) as thermo-responsive SMP incorporated with black-phosphorus (BP) sheets as NIR photothermal nanofillers. Under 808 nm light irradiation, the incorporated BP sheets with concentration of only 0.

2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.

One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of a 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared (NIR) light irradiation is described. The photothermal membrane, which is fabricated by an electrospinning poly(l-lactic acid) (PLLA) nanofibrous membrane loaded with bismuth selenide (BiSe) nanoplates, exhibits very high photothermal conversion efficiency and long-term stability.

Tri-phase all-optical switching and broadband nonlinear optical response in BiSe nanosheets.

This paper describes the tri-phase all-optical switching and broadband nonlinear optical response in BiSe nanosheets. Using BiSe nanosheets dispersion solution as the sample, the spatial phase of controlled light can be modulated as three phases (unchanging, focusing, diffraction) by changing the incident intensity of controlling light. The mechanism is conjectured that the controlling light changes the phase distribution of overlapping region and then modulates the phase distribution of the controlled light.