Publications by authors named "Hanhai Mao"
Parasitic helminth Trichinella spiralis (Ts) induce mixed Th1/Th2 response with predominant type 2 immune responses, with protective immunity mediated by interleukin (IL)-4, IL-5, and IL-13. β-Glucan (BG) has been shown to have the ability to induce trained immunity, confers non-specific protection from secondary infections. However, whether BG-induced trained immunity played a role in protective type 2 immunity against Ts infection is unclear.
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- The study investigates the role of gut microbiota in cardiac fibrosis caused by the helminth Trichinella spiralis, using infected mice as a model.
- Findings show that depleting gut microbes with antibiotics worsens cardiac fibrosis, while restoring microbiota through fecal transplants helps alleviate the condition.
- Increased levels of the gut microbe Akkermansia muciniphila in infected mice improve cardiac fibrosis, suggesting a potential therapeutic approach through oral supplementation.