Publications by authors named "Hanh Tam Tran"
Article Synopsis
- The study analyzed breast cancer patients at Johns Hopkins from 2010 to 2021 to determine if those with genetic variants had a higher likelihood of multifocal or multicentric breast cancer (MFMC).
- Among 282 patients, 24% tested positive for a genetic variant, but there was no significant difference in MFMC rates between variant carriers and non-carriers (28% vs. 22%).
- The findings suggest that having a genetic variant does not increase the risk of developing MFMC breast cancer, contrary to some beliefs regarding breast-conserving surgery in BRCA gene carriers.
Purpose: Axillary Lymph Node Dissection (ALND) is recommended for breast cancer patients who present with clinically node positive disease (cN1) especially if they have residual nodal disease (ypN+) following neoadjuvant therapy (NAT). It is unknown whether axillary dissection improves outcome for these patients.
Methods: A prospectively maintained database was used to identify all patients who were diagnosed with cTis-T4N1M0 breast cancer treated with NAT.
Article Synopsis
- A study investigated the effects of a simplified multidisciplinary clinic (s-MDC) on treatment patterns and perceptions of adjuvant radiation therapy (RT) and hormone therapy (HT) for older adults (≥65 years) with stage I, ER-positive breast cancer after surgery.
- A total of 127 patients were analyzed: 33 from the s-MDC and 94 from traditional consultations, with assessments done through validated questionnaires for decision-making preferences and patient experiences.
- The findings showed no significant difference in RT and HT usage between the two groups, although patients in the s-MDC had smaller tumors and higher comorbidity indices, indicating differences in their healthcare profiles.
Background: As tumor biology takes precedence over anatomic staging to determine breast cancer (BC) prognosis, there is growing interest in limiting axillary surgery. There is a need for tools to identify patients at the lowest risk of harboring axillary lymph node (ALN) disease, to determine when omission of sentinel lymph node biopsy (SLNB) may be appropriate. We examined whether a nomogram using preoperative axillary ultrasound (axUS) findings, clinical tumor size, receptor status, and grade to calculate the probability of nodal metastasis (PNM) has value in surgical decision making.
View Article and Find Full Text PDFIntraductal papilloma falls under the category of benign breast mass. However, recent studies show that it can harbor occult carcinoma. The management of benign intraductal papilloma remains controversial because of its nonspecific radiologic and histological findings, as well as its association with surrounding malignant pathology.
View Article and Find Full Text PDFBackground: The ACOSOG Z0011 (Z11) trial demonstrated that in patients with nonpalpable axillary lymph nodes (LN) and one to two positive sentinel LN (SLN), axillary LN dissection (ALND) is unnecessary.JAMA 305:569-575, [2011], Ann Surg 264:413-42, [2016] The Z11 trial did not require preoperative axillary ultrasound (axUS). In many centers, preoperative axUS is part of the standard workup of a newly diagnosed breast cancer patient, but in light of the Z11 results, its role is now questioned.
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