Publications by authors named "Hangyu Liu"

Exploiting high-performance gas sensors is desirable for the on-site and accurate detection of drug precursor chemical gases. Here, the electron-proton conductivity metal-organic frameworks M(HIB) were designed to discriminate typical drug precursor chemical gases. The strong d-π conjugation and substantial HO ligands in M(HIB) generate conducting pathways for electrons and protons, which contribute to novel gas-sensing properties.

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Background: Three-dimensional (3D) visualization has become increasingly prevalent in orthopedic education to tackle the distinct anatomical challenges of the field. However, there is a conspicuous lack of systematic reviews that thoroughly evaluate both the advantages and drawbacks of integrating 3D with problem-based learning (3D + PBL).

Methods: A rigorous search of English databases (Cochrane Library, Embase, PubMed, Scopus, and Web of Science) and Chinese databases (National Knowledge Infrastructure: CNKI, Chongqing VIP: VIP, and Wan Fang) were performed up to July 2024 to identify relevant studies.

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  • The study investigates why Vδ2 T cell-based immunotherapy for cervical cancer is not as effective as hoped, focusing on the mechanisms of T cell exhaustion.
  • Researchers analyzed tumor samples and cell lines to identify the role of BTN3A1 in enhancing exhaustion markers in Vδ2 T cells, which reduces their ability to fight cancer.
  • Findings suggest that inhibiting BTN3A1's effects can rejuvenate Vδ2 T cell function, highlighting potential strategies to improve immunotherapy outcomes in cervical cancer patients.
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Excellent stability, low cost, high response, and sensitivity of indium oxide (InO), a metal oxide semiconductor, have been verified in the field of gas sensing. Conventional InO gas sensors employ simple and easy-to-manufacture resistive components as transducers. However, the swift advancement of the Internet of Things has raised higher requirements for gas sensors based on metal oxides, primarily including lowering operating temperatures, improving selectivity, and realizing integrability.

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Objective: Tuberculosis (TB) is the leading cause of mortality worldwide. Previous studies have reported that TB susceptibility can be caused by vitamin D deficiency, which is affected by polymorphisms in the vitamin D receptor () gene. However, these results have been inconsistent.

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Background: The incidence of composite endpoint of early safety (CEES) after transcatheter aortic valve replacement (TAVR) has been a topic of focus within the cardiovascular field due to its impact on long-term patient outcomes. Timely prophylactic interventions are crucial for patients identified as high risk for CEES through preoperative risk stratification.

Objectives: This study aimed to explore the connection between inflammatory and nutritional markers, specifically the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI), and CEES occurrence.

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  • Epithelial-derived cytokines, particularly IL-33, play a significant role in type 2 inflammation, notably in allergic asthma, especially in children.
  • In a study using a mouse model, researchers found that IL-33 is crucial for neonatal lung health and the development of allergic asthma, while its impact in adults is limited.
  • The findings suggest that age is an important factor in how IL-33 affects immune responses, indicating that treatments for asthma should consider the age of the patient.
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Predicting the health status of lithium-ion batteries is crucial for ensuring safety. The prediction process typically requires inputting multiple time series, which exhibit temporal dependencies. Existing methods for health status prediction fail to uncover both coarse-grained and fine-grained temporal dependencies between these series.

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As a stable, low-cost, environment-friendly, and gas-sensitive material, semiconductor metal oxides have been widely used for gas sensing. In the past few years, single-atom catalysts (SACs) have gained increasing attention in the field of gas sensing with the advantages of maximized atomic utilization and unique electronic and chemical properties and have successfully been applied to enhance the detection sensitivity and selectivity of metal oxide gas sensors. However, the application of SACs in gas sensors is still in its infancy.

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Introduction: Septic cardiomyopathy is a sepsis-mediated cardiovascular complication with severe microcirculatory malperfusion. Emerging evidence has highlighted the protective effects of pulsatile flow in case of microcirculatory disturbance, yet the underlying mechanisms are still elusive. The objective of this study was to investigate the mechanisms of N 6 -methyladenosine (m 6 A) modification in the alleviation of septic cardiomyopathy associated with extracorporeal membrane oxygenation (ECMO)-generated pulsatile flow.

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  • This study looks at how our immune system changes as we grow older and become frail.
  • Researchers compared immune cells from newborns, young adults, and both healthy and frail older people to see what's different.
  • They found specific immune cell patterns in frail individuals, which may help us understand aging and could lead to better treatments in the future.
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Background: Depressive symptoms are strongly associated with the development of various diseases and are one of the leading causes of disability in the world. However, the relationship between weight-adjusted waist index (WWI) and depressive symptoms has not been studied. This study aimed to assess the relationship between depressive symptoms and WWI.

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Non-syndromic Cleft Lip and Palate (NSCLP) is one of the most common congenital craniofacial malformations. However, there is no enough knowledge about its mechanism, even through many relevant studies verify that cleft lip and palate is caused by interactions between environmental and genetic factors. SATB2 gene is one of the most common candidate genes of NSCLP, and the development of epigenetics provides a new direction on pathogenesis of cleft lip and palate.

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Objectives: The objective of this study was to evaluate the association between weight-adjusted waist index (WWI) and the prevalence of kidney stones among adults in the United States.

Methods: The cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007-2018. A total of 31,344 participants were categorized into two groups: those with kidney stones and those without.

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  • Brachial cleft carcinoma is a rare type of head and neck cancer, which has inconsistent diagnostic classifications among medical professionals.
  • A 63-year-old male initially diagnosed with this carcinoma after a neck mass surgery was later found to have left soft palate cancer and esophageal cancer, raising questions about the original diagnosis.
  • Diagnosing primary squamous cell carcinoma from branchial cleft cysts requires strict criteria, including pathology tests and exclusion of other potential cancers.
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Large mural thrombi in the relatively normal ascending aorta are extremely uncommon conditions that may lead to major adverse cardiovascular events due to new embolism. Because of their changeable variations, the management of these unstable thrombi is challenging and controversial. The size, morphology, location, embolic involvement, and patients' conditions are all crucial for therapeutic decision-making.

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Purpose: To describe a case of Bilateral Morning Glory Syndrome (MGS) associated with Unilateral Persistent Fetal Vasculature (PFV) in a 3-day old neonate.

Observations: A 3-day-old neonate was found bilateral retinal abnormalities due to neonatal eye screening. Dilated fundus exam showed bilateral optic disc dysplasia with the persistent hyaloid vessels in right eye at first.

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The worldwide prevalence of pancreatic cancer has been rising in recent decades, and its prognosis has not improved much. The imbalance of substance and energy metabolism in tumour cells is among the primary causes of tumour formation and occurrence, which is often controlled by the neuroendocrine system. We applied Cox and LASSO regression analysis to develop a neuroendocrine regulation- and metabolism-related prognostic risk score model with three genes (GSK3B, IL18 and VEGFA) for pancreatic cancer.

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Music therapy is increasingly being used to promote physical health. Emotion semantic recognition is more objective and provides direct awareness of the real emotional state based on electroencephalogram (EEG) signals. Therefore, we proposed a music therapy method to carry out emotion semantic matching between the EEG signal and music audio signal, which can improve the reliability of emotional judgments, and, furthermore, deeply mine the potential influence correlations between music and emotions.

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Article Synopsis
  • A new self-aligned patterning technique is proposed to improve precision in creating defect centers in photonic structures, achieving a doping precision of about 15 nm.
  • The method was used to create diamond nanopillar sensor arrays, resulting in high consistency, photon counts near theoretical limits, and exceptional yield rates.
  • The developed sensors demonstrate strong fluorescence rates and enhanced spin properties, making this approach suitable for advancing quantum sensing and information processing technologies.
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  • 5-Hydroxymethylcytosine (5hmC) is a crucial RNA modification that impacts various biological processes.
  • The study presents a machine learning-based approach to effectively identify 5hmC-modified regions in RNA sequences.
  • Utilizing the dna2vec algorithm for sequence feature embedding, the new model outperforms existing state-of-the-art methods, with datasets and source codes available online.
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Synopsis of recent research by authors named "Hangyu Liu"

  • - Hangyu Liu's recent research focuses on various aspects of cancer treatment and biomarker analysis, particularly emphasizing the role of Vγ9Vδ2 T cells in cervical cancer and their mechanisms of exhaustion, which could inform future immunotherapy strategies.
  • - Liu also investigates the properties and advancements in indium-oxide-based gas sensors, highlighting their applications in the evolving landscape of the Internet of Things, where performance and integrability requirements are increasing.
  • - Additionally, Liu explores the genetic polymorphisms related to tuberculosis susceptibility and the role of inflammatory markers in cardiovascular event predictability, showcasing a breadth of interest in both molecular genetics and clinical medicine.

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