Publications by authors named "Hangwei Zhuang"
Background: Quantitative susceptibility mapping (QSM) can study the susceptibility values of brain tissue which allows for noninvasive examination of local brain iron levels in both normal and pathological conditions.
Purpose: Our study compares brain iron deposition in gray matter (GM) nuclei between cerebral small vessel disease (CSVD) patients and healthy controls (HCs), exploring factors that affect iron deposition and cognitive function.
Materials And Methods: A total of 321 subjects were enrolled in this study.
Objective: The objective of this study was to evaluate the whole-brain pattern of oxygen extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen consumption (CMRO) perturbation in Alzheimer's disease (AD) and investigate the relationship between regional cerebral oxygen metabolism and global cognition.
Methods: Twenty-six AD patients and 25 age-matched healthy controls (HC) were prospectively recruited in this study. Mini-Mental State Examination (MMSE) was used to evaluate cognitive status.
Article Synopsis
- Normal pressure hydrocephalus (NPH) can affect brain function and may be treatable with shunt surgery in about 60% of cases; imaging techniques like MRI are used to assess brain viability and oxygen use in these patients.
- Researchers analyzed 16 NPH patients by mapping oxygen extraction fraction (OEF) and cerebral blood flow (CBF) through specialized MRI methods, looking at the impact of various factors including age and brain volume.
- Findings showed that lower OEF was strongly linked to larger brain ventricular volumes, suggesting that as NPH severity increases, brain tissue oxygen usage decreases; this indicates that OEF mapping could help in tracking disease progression and treatment response.
Purpose: Tissue magnetic susceptibility sign can potentially be detected on susceptibility weighted imaging (SWI) phase (SW-P). This study aims to investigate its performance for depicting brain susceptibility structures.
Methods: A simulation was performed to depict magnetic susceptibility structures of various geometries on SW-P and quantitative susceptibility mapping (QSM).