Reactive Oxygen Species-Responsive Nanoparticle Delivery of Small Interfering Ribonucleic Acid Targeting Olfactory Receptor 2 for Atherosclerosis Theranostics.

Atherosclerosis (AS) is a chronic inflammatory disorder characterized by arterial intimal lipid plaques. Small interfering ribonucleic acid (siRNA)-based therapies, with their ability to suppress specific genes with high targeting precision and minimal side effects, have shown great potential for AS treatment. However, targets of siRNA therapies based on macrophages for AS treatment are still limited.

DNA Framework-Enabled 3D Organization of Antiarrhythmic Drugs for Radiofrequency Catheter Ablation.

Preorganizing molecular drugs within a microenvironment is crucial for the development of efficient and controllable therapeutic systems. Here, the use of tetrahedral DNA framework (TDF) is reported to preorganize antiarrhythmic drugs (herein doxorubicin, Dox) in 3D for catheter ablation, a minimally invasive treatment for fast heartbeats, aiming to address potential complications linked to collateral tissue damage and the post-ablation atrial fibrillation (AF) recurrence resulting from incomplete ablation. Dox preorganization within TDF transforms its random distribution into a confined, regular spatial arrangement governed by DNA.

Collaborative Learning and Style-Adaptive Pooling Network for Perceptual Evaluation of Arbitrary Style Transfer.

Although the research of arbitrary style transfer (AST) has achieved great progress in recent years, few studies pay special attention to the perceptual evaluation of AST images that are usually influenced by complicated factors, such as structure-preserving, style similarity, and overall vision (OV). Existing methods rely on elaborately designed hand-crafted features to obtain quality factors and apply a rough pooling strategy to evaluate the final quality. However, the importance weights between the factors and the final quality will lead to unsatisfactory performances by simple quality pooling.

The serum soluble scavenger with 5 domains levels: A novel biomarker for individuals with heart failure.

We aimed to explore the relationship between the serum Soluble Scavenger with 5 Domains (SSC5D) levels and heart failure (HF). We retrospectively enrolled 276 patients diagnosed with HF or normal during hospitalization in Shanghai General Hospital between September 2020 and December 2021. Previously published RNA sequencing data were re-analyzed to confirm the expression profile of in failing and non-failing human and mouse heart tissues.

Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.

Background And Aims: During the development of atherosclerosis, nicotine activates macrophage inflammation. However, whether nicotine induces macrophage pyroptosis and the underlying mechanisms remain unclear. This study aimed to investigate the role of histone deacetylase 6 (HDAC6) in nicotine-induced macrophage pyroptosis.

Nicotine Modulates CTSS (Cathepsin S) Synthesis and Secretion Through Regulating the Autophagy-Lysosomal Machinery in Atherosclerosis.

Objective: Increased CTSS (cathepsin S) has been reported to play a critical role in atherosclerosis progression. Both CTSS synthesis and secretion are essential for exerting its functions. However, the underlying mechanisms contributing to CTSS synthesis and secretion in atherosclerosis remain unclear.

The interaction between STAT3 and nAChRα1 interferes with nicotine-induced atherosclerosis via Akt/mTOR signaling cascade.

During atherosclerosis development, nicotine and its α1 nicotinic acetylcholine receptors (nAChRα1) activate atherogenic inflammation. However, the effect of signal transducer and activator of transcription 3 (STAT3)-related inflammatory pathways in nicotine-induced atherosclerosis has been poorly studied. This study investigated the transcriptional mechanism of STAT3 in nicotine/nAChRα1-induced atherosclerosis.

Synthesis of Oxylipin Mimics and Their Antifungal Activity against the Citrus Postharvest Pathogens.

Nine oxylipin mimics were designed and synthesized starting from d-mannose. Their antifungal activity against three citrus postharvest pathogens was evaluated by spore germination assay. The results indicated that all the compounds significantly inhibited the growth of Penicillium digitatum, Penicillium italicum and Aspergillus niger.

The value of early diagnostic screens for the diagnosis of influenza A, B and Mycoplasma pneumoniae infections.

Background: Rapid diagnosis of influenza virus and Mycoplasma pneumoniae infections is of importance for therapeutic intervention. It was the aim of the study to evaluate screening tests for influenza A (Flu A), B (Flu B), and Mycoplasma pneumoniae (M. pneumoniae) infections in young patients admitted to the hospital.

Evaluation of a rapid detection influenza virus a antigens kit using paired serum antibody test.

Purpose: To evaluate the feasibility for gold immunochromatographic assay (GICA) in rapid detection of influenza virus A infection.

Materials And Methods: Seventy-three patients were enrolled. All patients contributed nasopharyngeal secretions and paired serum samples.

Pulmonary embolism excluded acute coronary syndrome by coronarography: a retrospective analysis.

Background: Pulmonary embolism (PE) is often mistaken as acute coronary syndromes (ACS) because of the considerable overlap in their clinical features. We evaluated the factors causing misdiagnosis of PE as ACS and factors that differentiate PE from ACS to improve the diagnosis efficacy of PE.

Methods: The medical records of 22 consecutive PE patients, between 2001 and 2010, who were initially suspected of ACS were retrieved.

Depression, anxiety and influencing factors in patients with acute pulmonary embolism.

Background: Psychological distress has been widely studied in many cardiovascular and pulmonary diseases, but the condition in acute pulmonary embolism (APE) is unknown. The purpose of this study was to investigate levels of depression and anxiety and their influencing factors in APE patients.

Methods: Sixty consecutive patients with APE were subjected to investigation of depression and anxiety by the Beck Depression Inventory and State-Trait Anxiety Inventory, and 60 community-based subjects were enrolled as controls.

The evaluation of colloidal gold immunochromatographic assay (GICA) for rapid diagnosis of influenza A disease.

Background: A low cost colloidal gold immunochromatographic assay (GICA) for rapid detection of influenza A virus was developed. The assay was evaluated in this study.

Methods: Six hundred and twenty-six patients were enrolled.

Evaluation of the commercial rapid Mycoplasma pneumoniae medium method using the medium PCR and serum antibody test.

Background: Mycoplasma pneumoniae (M. pneumoniae) is a major cause of respiratory tract infection. There is no specific and simple diagnosis test for the clinic treatment.

Screening for influenza viruses in 7804 patients with influenza-like symptoms.

Objective: To screen a large number of patients with influenza-like symptoms by using the gold-immunochromatographic assay kit.

Methods: All patients with influenza-like symptoms visiting the outpatient department of the General Hospital of Beijing Military Region, Beijing, China between May 2009 and January 2010 were enrolled in the study. Nasopharyngeal swabs were collected immediately after the patient visited, then a gold-immunochromatographic assay was performed for screening of influenza A and B viruses according to the kit protocol.

[The low molecular weight heparin on rat pulmonary surfactant associated protein A of acute pulmonary embolism].

Objective: To explore the effect of low molecular weight heparin (LMWH) on the changes of pulmonary surfactant associated protein A (SPA) of rats in acute pulmonary embolism.

Methods: Male SD rats were injected with medical gelfoam microspheres via jugular vein to induce PE model. Rats were randomized into three groups: control group (n = 8), embolism for 2 weeks group (n = 8) and LMWH therapy group (n = 8); The LMWH therapy group were injected Nadroparin subcutaneously immediately after operation, 0.