Mulberrin suppresses gastric cancer progression and enhances chemosensitivity to oxaliplatin through HSP90AA1/PI3K/AKT axis.

Background: Mulberrin, a natural flavonoid featured with two isopentenyl groups, is derived from the mulberry family. Although previous researches have uncovered various properties of mulberrin, including the antioxidant, hypoglycemic, antibacterial, food-preserving, skin-whitening and life-extending effects in nematode, its potential therapeutic application and the underlying mechanism in gastric cancer (GC) remains largely unexplored.

Purpose: This research intends to examine the anti-tumoral effects of mulberrin and reveal the molecular mechanism through which mulberrin inhibits the GC progression.