Objectives: To determine the outcomes of the second transurethral resection of bladder tumors.
Methods: Patients with bladder cancer who accepted both initial and second resections in our center from January 2021 to March 2024 were included. Tumor residue in the second resection and short-term oncological outcomes were determined.
This study examined the effects of Accentuated Eccentric Loading Countermovement Jump (AEL CMJ) training on jump performance, lower body strength, sprint performance, and change of direction ability, compared to drop jump (DJ) training. This study used a randomized controlled trial (RCT) with a parallel design. Forty men physical education students (Mean ± SD: age 22.
View Article and Find Full Text PDFRNA-binding proteins (RBPs) are pivotal mediators of the alternative splicing (AS) machinery of pre-mRNA. Research has demonstrated that the AS process is significantly dysregulated and plays a crucial role in bladder cancer (BLCA). We conducted comprehensive screening and analysis of the TCGA-BLCA cohort, specifically focusing on genes with significant differences in expression levels between carcinoma and adjacent non-cancerous tissues.
View Article and Find Full Text PDFRolling is a crucial step in black tea manufacturing. Rolling is achieved through a rolling machine, which achieves the processes of crushing, tearing, and curling. At present, the lack of intelligent detection for black tea rolling quality has limited the development of automation in the black tea industry.
View Article and Find Full Text PDFThe study investigated the mechanism of ALDH2 in mitochondrial dysfunction and blood-brain barrier (BBB) damage arising from chronic cerebral hypoperfusion (CCH). A rat model of bilateral common carotid artery occlusion (BCCAO) was established and treated with AAV-ALDH2. ALDH2 expression, cognitive function, and levels of inflammation- and oxidative stress-related factors, were examined, followed by observing changes in BBB and mitochondrial functions.
View Article and Find Full Text PDFAmorphous boron nitride (aBN) films, with extremely low relative dielectric constant () and chemical inertness, are excellent insulation and packaging materials for electronic device interconnection. It is of great significance to prepare the low-aBN films with controllable thickness, but there are still some limitations to achieve the goal. In this study, we succeed in growing wafer-scale aBN films with specific thicknesses from 1.
View Article and Find Full Text PDFPurpose: To evaluate the efficacy of an enhanced recovery after surgery (ERAS) strategy for upper tract urothelial carcinoma (UTUC) patients undergoing laparoscopic radical nephroureterectomy (LRNU).
Methods: 90 patients who received LRNU at Zhongnan Hospital of Wuhan University between January 2018 and July 2022 were retrospectively analyzed, including 43 in the ERAS group and 47 in the pre-ERAS group. The clinical features, postoperative complications, length of hospital stay (LOS), and hospital expenditures of the two groups were compared via t-test, Mann-Whitney test, and Chi-square test.
Background: The efficacy of microwave ablation (MWA) and radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) patients with decompensated cirrhosis remains unclear.
Methods: A total of 315 patients with decompensated cirrhosis and HCC who underwent MWA or RFA were recruited. Recurrence beyond the Milan criteria (RBM), local tumor progression (LTP), overall survival (OS), and complications were evaluated and compared.
Background: Radiomic features and deep features are both vitally helpful for the accurate prediction of tumor information in breast ultrasound. However, whether integrating radiomic features and deep features can improve the prediction performance of tumor information is unclear.
Methods: A feature fusion method based on radiomic features and revised deep features was proposed to predict tumor information.
Objectives: This study aims to describe a novel dorsal venous complex (DVC) ligation-free and parietal endopelvic fascia preserving technique for laparoscopic radical prostatectomy and to evaluate its post-operative outcomes.
Methods: From April 2020 to May 2021, a total of 125 patients with localized prostate cancer received laparoscopic radical prostatectomy by a single surgeon. In the procedure, a novel technique of DVC ligation-free and parietal endopelvic fascia preserving was used.
Integrating scientific principles into machine learning models to enhance their predictive performance and generalizability is a central challenge in the development of AI for Science. Herein, we introduce Uni-p , a novel framework that successfully incorporates thermodynamic principles into machine learning modeling, achieving high-precision predictions of acid dissociation constants (p ), a crucial task in the rational design of drugs and catalysts, as well as a modeling challenge in computational physical chemistry for small organic molecules. Uni-p utilizes a comprehensive free energy model to represent molecular protonation equilibria accurately.
View Article and Find Full Text PDFBackground: The burden of common urologic diseases, including benign prostatic hyperplasia (BPH), urinary tract infections (UTI), urolithiasis, bladder cancer, kidney cancer, and prostate cancer, varies both geographically and within specific regions. It is essential to conduct a comprehensive and precise assessment of the global burden of urologic diseases.
Methods: We obtained data on incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for the aforementioned urologic diseases by age, sex, location, and year from the Global Burden of Disease (GBD) 2021.
Bladder cancer(BC) is one of the most prevalent cancers in the urinary tract, with high recurrence and fatality rates. Research indicates that go-ichi-ni-san complex subunit 1 (GINS1) crucially influences cancer progression by regulating DNA replication through cell cycle modulation. Thus, suppressing the active proliferation of cells in tumor tissues may require silencing GINS1.
View Article and Find Full Text PDFCell-free DNA (cfDNA), a burgeoning class of molecular biomarkers, has been extensively studied across a variety of biomedical fields. As a key component of liquid biopsy, cfDNA testing is gaining prominence in disease detection and management due to the convenience of sample collection and the abundant wealth of genetic information it provides. However, the broader clinical application of cfDNA is currently impeded by a lack of standardization in the preanalytical procedures for cfDNA analysis.
View Article and Find Full Text PDFNatural killer (NK) cells represent key player in immune surveillance to eliminate transformed or malignant cells. One of mechanisms of action of NK cells is antibody-dependent cell-mediated cytotoxicity (ADCC) by recognizing tumor antigens on the surface of cancer cells. However, the heterogeneity of tumor antigens and the scarcity of membrane surface targets significantly restrict this strategy.
View Article and Find Full Text PDFThe aim of this systematic review is to comprehensively assess the weight loss (WL) practices in different combat sports (CS). The review protocol was preregistered with PROSPERO [CRD42023487196]. Three databases were searched (Web of Science, EBSCOhost, and PubMed) until 8 December 2023.
View Article and Find Full Text PDFMarburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates to prevent or treat virus disease. However, no antibody has been approved for MARV treatment to date.
View Article and Find Full Text PDFBackground: Hepatoid adenocarcinoma (HAC) is rare in the urinary system, with only 7 reported cases in upper urinary tract. This report aimed to explore the genetic characteristics of ureteral HAC for first time, and to describe the treatment prognosis of ureteral HAC.
Case Presentation: We present a rare case of ureteral HAC in a 53-year-old female, showing elevated serum levels of AFP and CEA, prolonged chronic irritation may be an important cause of her ureteral HAC.
Biochim Biophys Acta Mol Basis Dis
February 2024
Marburg virus (MARV), one member of the Filoviridae family, cause sporadic outbreaks of hemorrhagic fever with high mortality rates. No countermeasures are currently available for the prevention or treatment of MARV infection. Monoclonal antibodies (mAbs) are promising candidates to display high neutralizing activity against MARV infection in vitro and in vivo.
View Article and Find Full Text PDFMacrophage-hitchhiked arsenic/AB bionic preparations were developed to improve the therapeutic effect on liver cancer by means of the tumor-targeting ability of macrophages . and cellular uptake assays demonstrated that arsenic/AB, with negatively charged particles of around 100-200 nm size, could hitchhike to macrophages. Dissolution experiments of arsenic/AB showed that arsenic/AB could delay the release of arsenic and ensure the safety of macrophages during its transport.
View Article and Find Full Text PDFIEEE Trans Image Process
November 2023
As a key problem of auto-vehicle applications, the goal of Anomaly Obstacle Segmentation (AOS) is to detect some strange and unexpected obstacles (possibly are unseen previously) on the drivable area, thereby equipping the semantic perceptual model to be tolerant of unknown things. Due to its practicality, recently AOS is drawing attentions and a long line of works are proposed to tackle the obstacles with almost infinite diversity. However, these methods usually focus less on the priors of driving scenarios and involve image re-generation or the retraining of perceptual model, which lead to large computational quantity or the degradation of perceptual performance.
View Article and Find Full Text PDFEpithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare variant of the inflammatory myofibroblastic tumor, characterized by more aggressive clinical course and nuclear membrane staining of anaplastic lymphoma kinase (ALK) with ALK rearrangement. An elderly male came to the clinic because of an accidental abdominal mass. Abdominal and pelvic enhanced CT revealed a tumor apparently orginated from mesenchymal tissue.
View Article and Find Full Text PDFBackground: Conducting of clinical trials for rare diseases faces multiple challenges. Patients' cognition and attitude toward clinical trials are crucial, which may affect their participation and compliance, and affect the schedule of clinical trials eventually.
Objective And Method: This study aims to explore the knowledge and attitudes of clinical trials of patients with rare diseases or patients' guardians.