Plasmon-Enhanced Fluorescence Paper Lateral Flow Strip for Point-of-Care Testing of SARS-CoV-2 Antigens.

Currently commercial colorimetric paper lateral flow immunoassays exhibit insufficient limit of detection (LOD) and limited clinical sensitivity toward the detection of SARS-CoV-2 antigens, which causes a high false negative rate. To mitigate this issue, a new plasmon-enhanced fluorescence probe was developed for paper lateral flow strips (PLFSs). The probe is made of a sandwich-structured Ag-core@silica@dye@silica-shell nanoparticle in which fluorescent dyes are sandwiched between the plasmonic Ag core and the silica outer shell, and the separation distance between the Ag core and the dye molecules is controlled by the silica space layer.

TAK-925 (danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-Induced Respiratory Depression and Sedation Without Affecting Analgesia in Healthy Adult Males.

Background: Orexin neuropeptides help regulate sleep/wake states, respiration, and pain. However, their potential role in regulating breathing, particularly in perioperative settings, is not well understood. TAK-925 (danavorexton), a novel, orexin receptor 2-selective agonist, directly activates neurons associated with respiratory control in the brain and improves respiratory parameters in rodents undergoing fentanyl-induced sedation.

Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo.

Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic and phasic action potential (AP) firing patterns in behavior mice. Besides AP numbers, whether and how different AP firing patterns per se modulate DA release remain largely unknown.

Universal analyzer for measuring the orbital angular momentum spectrum of a randomly fluctuated beam.

The orbital angular momentum (OAM) of beams provides an additional degree of freedom and has been applied in various scientific and technological fields. Accurate and quantitative measurement of intensity distributions across different OAM modes, referred to as the OAM spectrum of a beam, is crucial. Here, we propose a straightforward and efficient experimental setup for measuring the OAM spectrum of a randomly fluctuating beam.

Effective sensitization of Dy:H energy level by Tm ions in KPbBr crystal for 4.3 µm lasers.

To the best of our knowledge, this is the first study to investigate the use of Tm to sensitize the Dy ion and enhance the ∼4.3 µm emission from Dy:H → H in the KPbBr (KPB) crystal. The ∼4.

Enhancing automatic sleep stage classification with cerebellar EEG and machine learning techniques.

Sleep disorders have become a significant health concern in modern society. To investigate and diagnose sleep disorders, sleep analysis has emerged as the primary research method. Conventional polysomnography primarily relies on cerebral electroencephalography (EEG) and electromyography (EMG) for sleep stage scoring, but manual scoring is time-consuming and subjective.

[Development of Multi-Parameter Exercise Cardiopulmonary Function Evaluation System with Impedance Cardiogram Monitoring].

Cardiopulmonary exercise testing (CPET) refers to a method of measuring various indicators of the human body under gradually increasing exercise loads to objectively evaluate cardiopulmonary reserve function and exercise endurance. Currently, CPET detection systems primarily measure subjects' ECG, respiratory flow, oxygen (O ), and carbon dioxide (CO ) parameters. This paper introduces a non-invasive multi-parameter exercise cardiopulmonary function evaluation system that incorporates impedance cardiography monitoring.

Localization of micro bronchial stump fistulas via guidewire exploration: A case report.

Bronchopleural fistula (BPF), a common complication of lobectomy, is a pathological communication between the bronchus and the pleural space. The bronchial stump fistula (BSF), which is located on the bronchial stump, is a specific type of BPF. BSF can be directly diagnosed via bronchoscopy.

Proteomics and transcriptomic analyses provide new insights into the pectin polysaccharide biosynthesis in Premna puberula Pamp.

Premna puberula Pamp. is a plant with similarities to both food and medicine, which has attracted the attention of researchers because of the rich pectin in its leaves. However, the mechanism of efficient pectin accumulation remains unclear.

Energy enhancement of Nd,Sc:YAG crystal in passively Q-switched lasers.

We report on the laser performance of Nd,Sc:YAG (yttrium aluminum garnet), for the first time, to our knowledge. In this study, 10 at.% Sc ions were doped into the Nd:YAG crystal to form the Nd,Sc:YAG crystal, which improves the saturation flux while nearly maintaining the excellent properties of the Nd:YAG crystal.

Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.

We conducted a large-scale whole-brain morphometry study by analyzing 3.7 peta-voxels of mouse brain images at the single-cell resolution, producing one of the largest multi-morphometry databases of mammalian brains to date. We registered 204 mouse brains of three major imaging modalities to the Allen Common Coordinate Framework (CCF) atlas, annotated 182,497 neuronal cell bodies, modeled 15,441 dendritic microenvironments, characterized the full morphology of 1876 neurons along with their axonal motifs, and detected 2.

Haploid-Phased Chromosomal Telomere-to-Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosynthesis of Bioactive Alkaloids.

Natural indole alkaloids provide important medicinal resources and defences to environmental stresses. The Uncaria genus is a recorded traditional medicinal woody plant with high alkaloids. Genomic insights into alkaloid variation remain elusive.

Design of a broadband SiN waveguide amplifier based on a gain medium of ion-sliced titanium-doped sapphire.

In recent years, significant progress has been made in the on-chip integration of Ti:sapphire amplifiers and lasers, showing great potential in device miniaturization, cost reduction, and mass production. However, the further integration of such devices on standard CMOS platforms has been challenging due to its limits on the wafer bonding method between gain materials and substrates. Here, we present a novel, to the best of our knowledge, SiN on-chip broadband optical waveguide amplifier scheme with an ultra-wide bandwidth of 650-900 nm and a peak gain of 28 dB based on an ion-sliced Ti:sapphire platform.

The detection and utilization of volatile metabolomics in Klebsiella pneumoniae by gas chromatography-ion mobility spectrometry.

This research aimed to analyze the volatile compounds emitted during the proliferation of Klebsiella pneumoniae (K. pneumoniae) in the laboratory setting using gas chromatography-ion mobility spectrometry (GC-IMS) and to investigate the potential of volatile metabolomics for detecting carbapenemase-producing strains of K. pneumoniae.

Effects of E2 on the IDO1-mediated metabolic KYN pathway in OVX female mice.

The aim of this study was to investigate the role of 17β-estradiol (E2)-mediated oestrogen receptor (ER) in modulating the depressive-like behaviours of ovariectomy (OVX) mice and the associated mechanisms. E2 was administrated in OVX mice. The behaviour and physiological changes of OVX mice including immobility time in tail suspension test (TST) and forced swimming test (FST), levels of serum E2, inflammatory mediators, oxidative stress factors, indoleamine2,3-dioxygenase 1 (IDO1) and the neurotransmitters mediated by IDO1 activation were then recorded.

Microstructure Evolution of the Interface in SiC/TiC-TiSiC Composite under Sequential Xe-He-H Ion Irradiation and Annealing Process.

A new type of SiC/TiC-TiSiC composite was prepared by the Spark Plasma Sintering (SPS) method in this work. The phase transformation and interface cracking of this composite under ion irradiation (single Xe, Xe + He, and Xe + He + H ions) and subsequent annealing were analyzed using transmission electron microscopy (TEM), mainly focusing on the interface regions. Xe ion irradiation resulted in the formation of high-density stacking faults in the TiC coatings and the complete amorphization of SiC fibers.

CAPTURE-24: A large dataset of wrist-worn activity tracker data collected in the wild for human activity recognition.

Existing activity tracker datasets for human activity recognition are typically obtained by having participants perform predefined activities in an enclosed environment under supervision. This results in small datasets with a limited number of activities and heterogeneity, lacking the mixed and nuanced movements normally found in free-living scenarios. As such, models trained on laboratory-style datasets may not generalise out of sample.

Investigating the complex relationship and influencing factors of frailty on nutritional status in maintenance hemodialysis patients.

Introduction: Given the high prevalence and significant challenges of frailty, a state of increased vulnerability to adverse health outcomes, among maintenance hemodialysis (MHD) patients, this cross-sectional study aimed to investigate its prevalence and explore its association with nutritional status and other relevant factors.

Methods: The study involved 290 MHD patients with an average age of 52.98 ± 13.