Publications by authors named "Hang Wenlu"
Objective: To predict the targets of Bufei Huoxue capsule (, BFHX) using network pharmacology analysis and to explore its effects and functional targets in a silicotic rat model.
Methods: The drug and disease targets were correlated through network pharmacology analysis to explore the targets and signaling pathways of BFHX affecting silicosis. NR8383 cells were cultured to verify the core genes and pathways.
Research progress on the pathogenesis and prediction of pneumoconiosis among coal miners.
Environ Geochem Health
July 2024
Article Synopsis
- - Pneumoconiosis, a lung disease common among coal miners, stems from long-term coal dust inhalation and can lead to severe symptoms like pulmonary fibrosis, increased pain, and higher mortality rates, with no effective treatments available.
- - The disease's pathogenesis is complex, influenced by factors such as coal dust composition, particle size, shape, and concentration, but there is currently no standardized method for early prediction among miners.
- - This review highlights recent research on pneumoconiosis in coal miners, discussing its pathogenesis and the impact of coal dust, as well as introducing diagnostic methods like image analysis and biomarker detection, and addressing challenges in early screening.
Article Synopsis
- Lung adenocarcinoma (LUAD) is a common but challenging type of lung cancer, which shows poor survival rates despite advancements in treatment; recent studies highlight a link between ferroptosis and anti-PD-L1 therapy effectiveness.
- The research identified two subtypes of LUAD based on ferroptosis regulator expression, showing significant differences in PD-L1 levels and patient prognosis.
- SLC7A11 was found to be a key prognostic marker, negatively correlated with PD-L1 expression, and its overexpression impacted both PD-L1 levels and ferroptosis in LUAD cells, suggesting new avenues for combining therapies to improve patient outcomes.
Background: Nintedanib and pirfenidone are preferred pharmacological therapies for patients with idiopathic pulmonary fibrosis (IPF). However, evidence favoring antifibrotic therapy in patients with non-IPF fibrosing interstitial lung diseases (ILD) is limited.
Objective: To investigate the effects of antifibrotic therapy on disease progression, all-cause mortality, and acute exacerbation (AE) risk in patients with non-IPF fibrosing ILDs.
Background: Chronic obstructive pulmonary disease (COPD) is considered related to chronic systemic inflammation. Renin angiotensin system (RAS) inhibitor, exerting an anti-inflammatory action in many systems, has been demonstrated relevant to the pathogenesis of COPD. However, the association between RAS inhibitor use and prognosis of patients with COPD remains controversial.
View Article and Find Full Text PDFExperimental study on the effect of Si and P ion content in SiO2 exposure environment on the degree of pulmonary fibrosis.
Indian J Pathol Microbiol
February 2022
Article Synopsis
- Silicosis is a serious public health concern in developing nations and cannot be completely cured.
- The study aimed to investigate how silica exposure affects ion content and the expression of inflammatory cytokines TNF-α and TGF-β in alveolar lavage fluid (BALF) of rats over time, as well as their correlation with pulmonary fibrosis.
- Results showed that TNF-α levels increased before TGF-β, and silica content in BALF peaked at 7 days post-exposure, indicating a relationship between these cytokines and changes in ion levels, particularly phosphorus, which may be important in the progression of silicosis.
The incidence of pulmonary fibrosis (PF), a progressively fatal disease, has increased in recent years. However, there are no effective medicines available. Previous results have shown that sinensetin probably has some curative effects on PF.
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