PIAS family gene expression: implications for prognosis, immunomodulation, and chemotherapy response.

Background: Cancer remains one of the leading causes of mortality worldwide, characterized by uncontrolled cell proliferation and metastasis. Protein Inhibitor of Activated STAT (PIAS) family genes, comprising PIAS1, PIAS2, PIAS3, and PIAS4, are emerging as significant players in cancer biology due to their roles in SUMOylation, transcriptional regulation, and modulation of signal transduction pathways. This study provides a comprehensive analysis of PIAS family genes from a pan-cancer viewpoint.

The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage.

Background: Alcohol-associated liver disease (ALD) is a major clinical issue characterized by progressive stages, including hepatic steatosis, liver fibrosis, cirrhosis, and HCC. Patients with long-term chronic alcoholism often present with gut microbiota dysbiosis and reduced plasma levels of vitamin B6. This study aimed to verify that gut microbiota disruption in ALD significantly contributes to reduced in vivo production of vitamin B6 and to investigate the role of this reduction in the pathogenesis of ALD.

Lattice Strain Regulated by Hetero/Homo Atom Interface Merging on NiMo Nanocluster for High-Performance Hydrogen Production.

Lattice strain engineering represents a cutting-edge approach capable of delivering enhanced performance across various applications. The lattice strain can affect the performance of electrochemical catalysts by changing the binding energy between the surface-active sites and intermediates. In this work, lattice strain is regulated through a homo/heterogeneous atomic interface merging.

Toward mechanical proprioception in autonomously reconfigurable kirigami-inspired mechanical systems.

Mechanical metamaterials have recently been exploited as an interesting platform for information storing, retrieval and processing, analogous to electronic devices. In this work, we describe the design and fabrication a two-dimensional (2D) multistable metamaterial consisting of building blocks that can be switched between two distinct stable phases, and which are capable of storing binary information analogous to digital bits. By changing the spatial distribution of the phases, we can achieve a variety of different configurations and tunable mechanical properties (both static and dynamic).

A novel prognostic and therapeutic target biomarker based on complement-related gene signature in gastric cancer.

Background: Gastric cancer (GC) is one of the most prevalent cancer types that reduce human life expectancy. The current tumor-node-metastasis (TNM) staging system is inadequate in identifying higher or lower risk of GC patients because of tumor heterogeneity. Research shows that complement plays a dual role in the tumor development and progression of GC.

Phase transitions in 2D multistable mechanical metamaterials via collisions of soliton-like pulses.

In recent years, mechanical metamaterials have been developed that support the propagation of an intriguing variety of nonlinear waves, including transition waves and vector solitons (solitons with coupling between multiple degrees of freedom). Here we report observations of phase transitions in 2D multistable mechanical metamaterials that are initiated by collisions of soliton-like pulses in the metamaterial. Analogous to first-order phase transitions in crystalline solids, we observe that the multistable metamaterials support phase transitions if the new phase meets or exceeds a critical nucleus size.

Multi-scale failure mechanisms of hydraulic engineering exposed to seasonally frozen salinization environment: Integrating SBAS-InSAR and mechanical experiments.

Constructing hydraulic engineering ensures agricultural development and improves salinization environments. However, in seasonally frozen salinization regions, hydraulic engineering is prone to deformation failure. Leakage from canal raises the regional groundwater level, triggering secondary salinization environmental issues.

Associations of circulating immunomarkers with the efficacy of immunotherapy for primary hepatic carcinoma.

Background: Peripheral blood immunomarkers are associated with prognosis in patients with solid tumors receiving chemotherapy or immunotherapy. In this study, the associations of circulating neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR), as well as their dynamic changes were investigated in relation to the efficacy of immunotherapy in patients with primary liver cancer.

Methods: Comparisons were made between NLR, MLR, and PLR among individuals exhibiting disease control (defined as the best response of partial response [PR] or stable disease [SD]) and those with progressive disease (PD).

Impact of Heat Stress on Blood, Production, and Physiological Indicators in Heat-Tolerant and Heat-Sensitive Dairy Cows.

Heat stress affects production and health in cows severely. Since it is difficult to define heat-tolerant animals, studies of response to heat stress are important for understanding dairy cows' health and production. However, information on the impact of heat stress on various indicators in heat-tolerant and heat-sensitive cows is sparse.

A modular strategy for distributed, embodied control of electronics-free soft robots.

Robots typically interact with their environments via feedback loops consisting of electronic sensors, microcontrollers, and actuators, which can be bulky and complex. Researchers have sought new strategies for achieving autonomous sensing and control in next-generation soft robots. We describe here an electronics-free approach for autonomous control of soft robots, whose compositional and structural features embody the sensing, control, and actuation feedback loop of their soft bodies.

VSIG4 Silencing Inhibits Glioblastoma Growth by Regulating the JAK2/STAT3 Pathway.

Background: Glioblastoma (GBM) is the most common malignant primary brain tumour in adults. VSIG4 has been identified to be associated with GBM. We aimed to determine the downstream regulatory mechanisms of VSIG4 in GBM.

Current Attitudes of Chinese Dairy Practitioners to Pain and Its Management in Intensively Raised Dairy Cattle.

Pain in dairy cattle is gaining attention globally. This study investigated the current attitudes of Chinese dairy practitioners to pain and its management in intensively raised dairy cattle. A total of 465 valid questionnaires with 26 painful conditions scored on numerical rating scales were collected from dairy practitioners.

Endostar Synergizes with Radiotherapy to Inhibit Angiogenesis of Cervical Cancer in a Subcutaneous Xenograft Mouse Model.

Background: To investigate the synergic effect and underlying mechanism of Endostar, a recombinant human endostatin used for anti-angiogenesis, in radiotherapy for cervical cancer.

Methods: The Cell Counting Kit-8 (CCK-8) assay and plate cloning experiment were first employed to analyze the proliferation of HeLa and SiHa cervical cancer cells and human umbilical vein vascular endothelial cells (HUVECs). Flow cytometry was used to detect apoptosis and cell cycle progression.

Behavior Classification and Analysis of Grazing Sheep on Pasture with Different Sward Surface Heights Using Machine Learning.

Behavior classification and recognition of sheep are useful for monitoring their health and productivity. The automatic behavior classification of sheep by using wearable devices based on IMU sensors is becoming more prevalent, but there is little consensus on data processing and classification methods. Most classification accuracy tests are conducted on extracted behavior segments, with only a few trained models applied to continuous behavior segments classification.

Recognition of Cattle's Feeding Behaviors Using Noseband Pressure Sensor With Machine Learning.

Automatic monitoring of feeding behavior especially rumination and eating in cattle is important to keep track of animal health and growth condition and disease warnings. The noseband pressure sensor is not only able to accurately sense the pressure change of the cattle's jaw movements, which can directly reflect the cattle's chewing behavior, but also has strong resistance to interference. However, it is difficult to keep the same initial pressure while wearing the pressure sensor, and this will pose a challenge to process the feeding behavior data.

Classification and Analysis of Multiple Cattle Unitary Behaviors and Movements Based on Machine Learning Methods.

The behavior of livestock on farms is the primary representation of animal welfare, health conditions, and social interactions to determine whether they are healthy or not. The objective of this study was to propose a framework based on inertial measurement unit (IMU) data from 10 dairy cows to classify unitary behaviors such as feeding, standing, lying, ruminating-standing, ruminating-lying, and walking, and identify movements during unitary behaviors. Classification performance was investigated for three machine learning algorithms (K-nearest neighbors (KNN), random forest (RF), and extreme boosting algorithm (XGBoost)) in four time windows (5, 10, 30, and 60 s).

Evaluation of the Best Region for Measuring Eye Temperature in Dairy Cows Exposed to Heat Stress.

Eye temperature (ET) has long been used for predicting or indicating heat stress in dairy cows. However, the region of interest (ROI) and temperature parameter of the eye have not been standardized and various options were adopted by previous studies. The aim of this study was to determine the best ROI for measuring ET as the predictor of heat stress in dairy cows in consideration of repeatability and validity.

Evaluation of environmental and physiological indicators in lactating dairy cows exposed to heat stress.

This study aimed to better understand environmental heat stress and physiological heat strain indicators in lactating dairy cows. Sixteen heat stress indicators were derived using microenvironmental parameters that were measured at the surrounding of cows and at usual fixed locations in the barn by using handheld and fixed subarea sensors, respectively. Twenty high-producing Holstein-Friesian dairy cows (> 30.

Myelin Oligodendrocyte Glycoprotein Antibody Associated Cerebral Cortical Encephalitis: Case Reports and Review of Literature.

Myelin oligodendrocyte glycoprotein antibody-associated disease is an immune-mediated demyelinating disease of the central nervous system that is present in both adults and children. The most common clinical manifestations are optic neuritis, myelitis, acute disseminated encephalomyelitis, and brainstem syndrome. Cerebral cortical encephalitis (CCE) is a rare clinical phenotype of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), which usually begins with seizures, headaches, and fever, and may be misdiagnosed as viral encephalitis in the early stages.

Ecological Health Assessment of Chinese National Parks Based on Landscape Pattern: A Case Study in Shennongjia National Park.

Assessing the health of the ecosystem based on the landscape pattern of national parks can facilitate policy makers in formulating more targeted conservation policies to better manage national park ecosystems. To analyze the landscape patterns and characteristics of the national park, the ecosystem health evaluation index system of the national park was constructed using the vigor-organization-resilience (VOR) model to evaluate the health status. In this study, the Shennongjia National Park in China was selected as a case study area to be assessed using the index system.

Microbiota-Gut-Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics.

The gut-brain axis refers to the bidirectional communication between the gut and brain, and regulates intestinal homeostasis and the central nervous system neural networks and neuroendocrine, immune, and inflammatory pathways. The development of sequencing technology has evidenced the key regulatory role of the gut microbiota in several neurological disorders, including Parkinson's disease, Alzheimer's disease, and multiple sclerosis. Epilepsy is a complex disease with multiple risk factors that affect more than 50 million people worldwide; nearly 30% of patients with epilepsy cannot be controlled with drugs.

Effect of a synthetic feline facial pheromone product on stress during transport in domestic cats: a randomised controlled pilot study.

Objectives: Transport can be a stressful experience for domestic cats. The objective of this study was to evaluate the effect of a new synthetic feline facial pheromone product on relieving stress in domestic cats during short-distance transport.

Methods: A randomised, blinded, placebo-controlled pilot study was conducted.

The Efficacy and Safety of Continuous Intravenous Endostar Treatment Combined With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma: A Randomized Controlled Trial.

Objective: To investigate the short-term efficacy and safety of Endostar combined with concurrent chemoradiotherapy in the treatment of locally advanced cervical squamous cell carcinoma (LACSC).

Methods: A total of 91 patients with LACSC admitted to the First Affiliated Hospital of Anhui Medical University from June 2019 to December 2020 were randomly assigned to either the experimental group (n = 48) or control group (n = 43). The control group received radiotherapy for cervical cancer and paclitaxel combined with platinum chemotherapy (CCRT), and the experimental group received Endostar continuous intravenous infusion of anti-angiogenic therapy plus CCRT.

Endoscopic Endonasal Approach for Clipping Anterior Communicating Artery Aneurysms From Cadaver Studies and Three-Dimensional Printed Models to a Clinical Case.

Objectives: Anterior communicating artery (ACoA) aneurysm is one of the most common intracranial aneurysms, and it is also the aneurysm with the highest rupture rate. With the improvement of endoscopic techniques, it is possible to use an endoscopic endonasal approach (EEA) to clip ACoA aneurysms. For further analysis of the EEA for clipping ACoA aneurysms, we used cadaver heads and three-dimensional (3D)-printed models to finish the anatomical study, and we finally selected 1 clinical case to complete the clipping through the EEA.