Publications by authors named "Hang Shangguan"
Fluoride-based lanthanide-doped nanoparticles (LDNPs) featuring second near-infrared (NIR-II, 1000-1700 nm) downconversion emission for bioimaging have attracted extensive attention. However, conventional LDNPs cannot be degraded and eliminated from organisms because of an inert lattice, which obstructs bioimaging applications. Herein, the core-shell LDNPs of NaHfF:Yb,Er@CaF:Ce,Zr(Hf) [labeled as Zr(Hf)Ce-HC] with pH-selective and tunable degradability were synthesized for dual-modal bioimaging.
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- Upconversion and downconversion luminescent lanthanide-doped nanocrystals (LDNCs) are becoming popular in bioimaging due to their ability to be excited by near-infrared (NIR) light, but traditional versions are hard to degrade which limits their medical use.
- Researchers developed a new biodegradable LDNC called HZC, modified with oxidized sodium alginate, which features a "soft" lattice to allow adjustable degradation rates and improve bioimaging capabilities.
- The HZC nanocrystals show significantly enhanced emission qualities and can provide trimodal imaging (NIR-II, computed tomography, and upconversion), as well as ensuring compatibility with biological systems for better tumor diagnosis.
Although plant-derived cancer therapeutic products possess great promise in clinical translations, they still suffer from quick degradation and low targeting rates. Herein, based on the oxygen vacancy (OV)-immobilization strategy, an OV-enriched biodegradable silicate nanoplatform with atomically dispersed Fe/Mn active species and polyethylene glycol modification was innovated for loading gallic acid (GA) (noted as FMMPG) for intratumoral coordination-enhanced multicatalytic cancer therapy. The OV-enriched FMMPG nanozymes with a narrow band gap (1.
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