Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis.

Nicotinamide adenine dinucleotide (NAD) plays an important role in tumor progression, but its role in non-small cell lung cancer with brain metastasis (NSCLC BM) remains unclear. Herein, we investigated NAD biosynthesis targeting as a new therapeutic strategy for NSCLC BM. Therapeutic activity of nicotinamide phosphoribosyl transferase (NAMPT) inhibitors was evaluated in mouse models of NSCLC BM and using various assays such as NAD quantitation, cell viability, and apoptosis assays.

Dynamic Ionic Environment Modulation for Precise Electrosynthesis of Heterostructured Bimetallic Nanoparticles.

Bimetallic heterostructures, including core-shell and Janus configurations, often offer unique electrocatalytic properties compared to monometallic nanoparticles. However, achieving precise control over both elemental composition and spatial arrangement within these structures remains a challenge. Here, an electrosynthesis method is introduced that enables the fabrication of heterostructured bimetallic nanoparticles with precise, independent control of their elemental distribution.

PPP1R13L drives cervical cancer progression by suppressing p63-mediated PTEN transcription.

PPP1R13L is a conserved inhibitor of p53, selectively regulating a subset of p53 target genes. Previous studies have reported that PPP1R13L promotes cervical cancer progression, yet its precise mechanism remains unclear and warrants further investigation. In this study, we utilized public databases to reveal the correlation between PPP1R13L and tumor progression pathways.

Single-shot X-ray imaging of two-dimensional strain fields in colloidal crystals.

We used a soft X-ray free-electron laser and the Bragg coherent diffraction imaging method to characterize the defect structure of colloidal crystals. The single-shot X-ray pulse allowed us to reach four powder rings and measured all six reflections of the hexagonal lattice. We reproduced the static shape of the 2D crystal and mapped out the 2D strain tensors inside the crystal.

Facet-controlled electrosynthesis of nanoparticles by combinatorial screening in scanning electrochemical cell microscopy.

Controlled synthesis of faceted nanoparticles on surfaces without explicit use of ligands has gained attention due to their promising applications in electrocatalysis and chemical sensing. Electrodeposition is a desirable method; however, precise control over their size, spatial distribution, and morphology requires extensive optimization. Here, we report the spatially resolved synthesis of shape-controlled Pt nanoparticles and fast screening of synthesis conditions in scanning electrochemical cell microscopy (SECCM) with pulse potentials.

Kinetics and dynamics of atomic-layer dissolution on low-defect Ag.

Electrochemical metal dissolution reaction is a fundamental process in various critical technologies, including metal anode batteries and nanofabrication. However, experimentally revealing the kinetics and dynamics of active sites of metal dissolution reactions is challenging. Herein, we investigate metal dissolution on near-perfect single-crystal surfaces of Ag within regions of a few hundred nanometers isolated by scanning electrochemical cell microscopy (SECCM).

Gas-Liquid-Solid Three-Phase Boundary in Scanning Electrochemical Cell Microscopy.

The gas-liquid-solid interface plays a crucial role in various electrochemical energy conversion devices, including fuel cells and electrolyzers. Understanding the effect of gas transfer on the electrochemistry at this three-phase interface is a grand challenge. Scanning electrochemical cell microscopy (SECCM) is an emerging technique for mapping the heterogeneity in electrochemical activity; it also inherently features a three-phase boundary at the nanodroplet cell.

Advances in nonlinear metasurfaces for imaging, quantum, and sensing applications.

Metasurfaces, composed of artificial meta-atoms of subwavelength size, can support strong light-matter interaction based on multipolar resonances and plasmonics, hence offering the great capability of empowering nonlinear generation. Recently, owing to their ability to manipulate the amplitude and phase of the nonlinear emission in the subwavelength scale, metasurfaces have been recognized as ultra-compact, flat optical components for a vast range of applications, including nonlinear imaging, quantum light sources, and ultrasensitive sensing. This review focuses on the recent progress on nonlinear metasurfaces for those applications.

Identification of lu'an Guapian at different picking periods by using excitation-emission matrix fluorescence spectroscopy coupled with chemometrics.

Lu'an Guapian (LAGP) is a renowned green tea, with its price significantly higher when picked before the Qingming Festival compared to after, posing risks of confusion and counterfeiting. This study proposed using an excitation-emission matrix (EEM) fluorescence method combined with chemometrics for rapid identification of tea picked before and after Qingming Festival. Firstly, the differences among the EEM fingerprints of different tea samples were analyzed using the alternating trilinear decomposition (ATLD) algorithm.

Comprehensive multicentre retrospective analysis for predicting isocitrate dehydrogenase-mutant lower-grade gliomas.

Objective: To differentiate glioma grading and determine isocitrate dehydrogenase (IDH) mutation status, which are crucial for prognosis assessment and treatment planning in glioma patients.

Methods: This retrospective study included patients diagnosed with adult diffuse glioma from 1 January, 2018 to 31 July, 2023 in two independent institutions. It documented and analysed clinical and radiographic features.

construction of a vanadium dioxide and MXene heterostructure towards high-capacity ammonium ion storage.

A VO@VC (VO@VCM) anode material is prepared for aqueous ammonium ion batteries (AmIBs) by one-step oxidation of a 2D VC MXene. The VO@VCM delivers a high capacity of 226 mA h g, superior rate performance, and long cycling stability due to the synergistic effect of the highly conductive MXene and highly active VO.

Controlling the droplet cell environment in scanning electrochemical cell microscopy (SECCM) migration and electroosmotic flow.

Scanning electrochemical cell microscopy (SECCM) is a powerful nanoscale electrochemical technique that advances our understanding of heterogeneity at the electrode-electrolyte interface. In SECCM, dual-channel nanopipettes can serve as the probe, and a voltage bias between the channels can control the local electrolyte environment inside the droplet cell migration and electroosmotic flow (EOF) between the channels, enabling applications including controlled electrodeposition of bimetallic nanoparticles with variable compositions. Herein, we show quantitatively how the voltage bias between the channels modulates the local electrolyte environment experiment and finite element modeling.

Integrated terahertz topological valley-locked power divider with arbitrary power ratios.

Integrated power dividers (PDs) are essential in terahertz (THz) communication and radar systems, but miniaturization often leads to performance degradation due to fabrication inaccuracies and sharp bends. Topological photonics offers a solution to these issues, yet creating THz power dividers with arbitrary splitting ratios remains challenging. We present a design methodology for on-chip topological THz power dividers with customizable splitting ratios using valley-locked photonic crystals.

Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.

Background: β-Amyloid (Aβ) fibrillation is critical for Aβ deposition and cytotoxicity during the progression of Alzheimer's disease (AD). Consequently, anti-Aβ monoclonal antibody drugs targeting Aβ oligomers and aggregation are considered potential therapeutic strategies for AD treatment. Similar to the working mechanisms of anti-Aβ monoclonal antibody drugs, our study identified osmundacetone (OAC), a small-molecule compound isolated from the traditional Chinese medicine Rhizoma Osmundae, as exerting anti-AD effects by targeting Aβ.

Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice.

Increased astrocytic lactoferrin (Lf) expression was observed in the brains of elderly individuals and Alzheimer's disease (AD) patients. Our previous study revealed that astrocytic Lf overexpression improved cognitive capacity by facilitating Lf secretion to neurons to inhibit β-amyloid protein (Aβ) production in APP/PS1 mice. Here, we further discovered that astrocytic Lf overexpression inhibited neuronal loss by decreasing iron accumulation and increasing glutathione peroxidase 4 (GPX4) expression in neurons within APP/PS1 mice.

Identification of AS1842856 as a novel small-molecule GSK3α/β inhibitor against Tauopathy by accelerating GSK3α/β exocytosis.

Glycogen synthase kinase-3α/β (GSK3α/β) is a critical kinase for Tau hyperphosphorylation which contributes to neurodegeneration. Despite the termination of clinical trials for GSK3α/β inhibitors in Alzheimer's disease (AD) treatment, there is a pressing need for novel therapeutic strategies targeting GSK3α/β. Here, we identified the compound AS1842856 (AS), a specific forkhead box protein O1 (FOXO1) inhibitor, reduced intracellular GSK3α/β content in a FOXO1-independent manner.

Highly Efficient One-Pot Synthesis of 2,4,5-Trisubstituted 3(2)-Furanones Utilizing a Au(I)-Catalyzed Oxidation/Pinacol Rearrangement/-Michael Cascade.

A highly efficient Au(I)-catalyzed cascade reaction between bispropargylic alcohols and pyridine--oxides has been realized. The reaction process involved a gold(I)-catalyzed sequential oxidation/Pinacol rearrangement/oxacyclization. Moreover, 1,2-aryl, 1,2-alkyl, or 1,2-vinyl migration was favored over 1,2-alkynyl in the crucial gold(I)-catalyzed Pinacol rearrangement step.

Inhibition of Experimental Corneal Neovascularization by the Tight Junction Protein ZO-1.

To explore the effects of the tight junction protein zonula occludens 1 (ZO-1) on experimental corneal neovascularization (CNV). CNV models were established in the left eyes of BALB/c mice using NaOH. Anti-ZO-1 neutralizing antibody was topically applied to the burnt corneas after modeling thrice a day for 1 week.