Spatial Symmetry Operation Breaking Sulfur-Chiral Photoswitchable Ferroelectrics.

Ferroelectrics with switchable spontaneous polarization have gained enormous attention for a century. However, the structural phase transitions of conventional ferroelectrics have been mainly limited to the ones with crystallographic point group changes accompanied by the breaking of spatial symmetry elements. Moreover, although chiral and photoswitchable ferroelectrics have both been of great interest in recent years, heteroatomic chiral photoswitchable ferroelectrics have never been reported.

The First Kleinman-type Second-Harmonic Generation Circular Dichroism On/Off Switchable Ferroelectrics.

Chiral ferroelectrics have recently received considerable interest due to their unique chiroptical properties. They can adopt Kleinman symmetry second-harmonic generation (SHG)-active chiral-polar point groups in the ferroelectric phase while Kleinman symmetry SHG-inactive chiral-nonpolar point groups in the paraelectric phase, providing a great opportunity to realize on/off switching of SHG circular dichroism (SHG-CD) response. However, the SHG-CD effect was rarely explored in chiral ferroelectrics, and the on/off switchable SHG-CD has never been reported.

An organic-inorganic hybrid ferroelastic with a near-room-temperature phase transition.

Organic-inorganic hybrid metal halides (OIMHs) with ferroelastic phase transition properties have recently attracted great attention due to their widespread application prospects in the fields of energy storage, sensors, switches, . However, most of the hybrid ferroelastics exhibit phase transition points () far beyond room temperature, which may limit their applications in mechanical switches and energy storage for daily working requirements. Herein, we synthesized a new zinc halide OIMH ferroelastic (,)-[BPHD]ZnBr (BPHD = 1,6-bis(piperidine-1-yl) hexa-2,4-diene diamide), which experiences a 2/1̄ type paraelastic-ferroelastic phase transition at a near-room-temperature of 285 K.

Corrupted Point Cloud Classification Through Deep Learning with Local Feature Descriptor.

Three-dimensional point cloud recognition is a very fundamental work in fields such as autonomous driving and face recognition. However, in real industrial scenarios, input point cloud data are often accompanied by factors such as occlusion, rotation, and noise. These factors make it challenging to apply existing point cloud classification algorithms in real industrial scenarios.

Innovative Oral Nano/Gene Delivery System Based on Engineered Modified for Colorectal Cancer Therapy.

The efficient delivery of RNA-based drugs to solid tumors remains a formidable obstacle. We aim to develop a safe and efficient oral drug delivery system compatible with RNA-based drugs that is urgently needed to overcome challenges such as enzymatic degradation and gastrointestinal barriers to facilitate effective treatment for treating colorectal cancer (CRC). To address these challenges, we utilized engineered modified to evaluate the delivery efficacy of miR21-antagomir for treating CRC in preclinical mouse models, including adenomatosis polyposis coli mutant transgenic mice and in situ tumor-bearing mice.

RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2.

Background: Breast cancer (BC) is the most common malignant tumor in women worldwide, and further elucidation of the molecular mechanisms involved in BC pathogenesis is essential to improve the prognosis of BC patients. RNA Binding Motif Protein 8 A (RBM8A), with high affinity to a myriad of RNA transcripts, has been shown to play a crucial role in genesis and progression of multiple cancers. We attempted to explore its functional significance and molecular mechanisms in BC.

MZT2A serves as a prognostic biomarker and promotes the progression of kidney renal clear cell carcinoma.

MZT2A is a novel core component in the γ-tubulin ring complex and aberrantly expressed in some types of tumors. However, MZT2A expression pattern across different cancers and its role in kidney renal clear cell carcinoma have not been sufficiently investigated. A thorough analysis of MZT2A expression landscape across 33 cancer types was conducted, utilizing 712 normal samples and 9807 tumor samples from TCGA (version 37.

Discovery of molecular ferroelectric catalytic annulation for quinolines.

Ferroelectrics as emerging and attractive catalysts have shown tremendous potential for applications including wastewater treatment, hydrogen production, nitrogen fixation, and organic synthesis, etc. In this study, we demonstrate that molecular ferroelectric crystal TMCM-CdCl (TMCM = trimethylchloromethylammonium) with multiaxial ferroelectricity and superior piezoelectricity has an effective catalytic activity on the direct construction of the pharmacologically important substituted quinoline derivatives via one-pot [3 + 2 + 1] annulation of anilines and terminal alkynes by using N,N-dimethylformamide (DMF) as the carbon source. The recrystallized TMCM-CdCl crystals from DMF remain well ferroelectricity and piezoelectricity.

A Multiferroic Spin-Crossover Molecular Crystal.

Spin-crossover (SCO) ferroelectrics with dual-function switches have attracted great attention for significant magnetoelectric application prospects. However, the multiferroic crystals with SCO features have rarely been reported. Herein, a molecular multiferroic Fe(II) crystalline complex [Fe(C-F-pbh)] (1-F, C-F-pbh = (1Z,N'E)-3-F-4-(octyloxy)-N'-(pyridin-2-ylmethylene)-benzo-hydrazonate) showing the coexistence of ferroelectricity, ferroelasticity, and SCO behavior is presented for the first time.

Coupling intention and actions of vehicle-pedestrian interaction: A virtual reality experiment study.

The interactions between vehicles and pedestrians are complex due to their interdependence and coupling. Understanding these interactions is crucial for the development of autonomous vehicles, as it enables accurate prediction of pedestrian crossing intentions, more reasonable decision-making, and human-like motion planning at unsignalized intersections. Previous studies have devoted considerable effort to analyzing vehicle and pedestrian behavior and developing models to forecast pedestrian crossing intentions.

TGIF2 is a potential biomarker for diagnosis and prognosis of glioma.

Background: TGFB-induced factor homeobox 2 (TGIF2), a member of the Three-Amino-acid-Loop-Extension (TALE) superfamily, has been implicated in various malignant tumors. However, its prognostic significance in glioma, impact on tumor immune infiltration, and underlying mechanisms in glioma development remain elusive.

Methods: The expression of TGIF2 in various human normal tissues, normal brain tissues, and gliomas was investigated using HPA, TCGA, GTEx, and GEO databases.

Comprehensive analysis reveals TSPEAR as a prognostic biomarker in colorectal cancer.

Colorectal cancer (CRC) is one of the most common malignant tumors and has high morbidity and mortality rates. Previous studies have shown that TSPEAR mutations are involved in the development and progression of gastric cancer and liver cancer. However, the role of TSPEAR in CRC is still unclear.

A chiral two-dimensional perovskite-like lead-free bismuth(III) iodide hybrid with high phase transition temperature.

Bismuth(III) iodide perovskites have attracted great attention as lead-free hybrid semiconductors, but they mainly show zero- and one-dimensional structures. Herein, we report the first two-dimensional chiral perovskite-like bismuth(III) iodide hybrid [()-3-aminopyrrolidinium I]BiI () with a high phase transition temperature of 408.8 K, higher than most of the reported chiral lead-free hybrid semiconductors.

The First Enantiomeric Stereogenic Sulfur-Chiral Organic Ferroelectric Crystals.

Chiral ferroelectric crystals with intriguing features have attracted great interest and many with point or axial chirality based on the stereocarbon have been successively developed in recent years. However, ferroelectric crystals with stereogenic heteroatomic chirality have never been documented so far. Here, we discover and report a pair of enantiomeric stereogenic sulfur-chiral single-component organic ferroelectric crystals, R -tert-butanesulfinamide (R -tBuSA) and S -tert-butanesulfinamide (S -tBuSA) through the deep understanding of the chemical design of molecular ferroelectric crystals.

Fluorination Enables Dual Ferroelectricity in Both Solid- and Liquid-Crystal Phases.

Ferroelectric materials are a special type of polar substances, including solids or liquid crystals. However, obtaining a material to be ferroelectric in both its solid crystal (SC) and liquid crystal (LC) phases is a great challenge. Moreover, although cholesteric LCs inherently possess the advantage of high fluidity, their ferroelectricity remains unknown.

High- Single-Component Organosilicon Ferroelectric Crystal Obtained by H/F Substitution.

Organic single-component ferroelectrics are highly desirable for their low molecular mass, light weight, low processing temperature, and excellent film-forming properties. Organosilicon materials with a strong film-forming ability, weather resistance, nontoxicity, odorlessness, and physiological inertia are very suitable for device applications related to the human body. However, the discovery of high- organic single-component ferroelectrics has been very scarce, and the organosilicon ones even less so.

A photoluminescent chiral lead-free hybrid ferroelastic semiconductor with switchable second-harmonic generation.

Chiral organic-inorganic hybrid semiconductors (COIHSs) dominated by lead halides have recently gained tremendous interest. Here, we report a lead-free photoluminescent COIHS [-3-hydroxylpiperidinium]SbCl with a bandgap of 3.14 eV.

Advanced Sensing and Safety Control for Connected and Automated Vehicles.

The connected and automated vehicle (CAV) is a promising technology, anticipated to enhance the safety and effectiveness of mobility [...

Improving the activity and thermostability of PETase from Ideonella sakaiensis through modulating its post-translational glycan modification.

The large-scale preparation of Polyehylene terephthalate (PET) hydrolysing enzymes in low-cost is critical for the biodegradation of PET in industry. In the present study, we demonstrate that the post-translational glycosylation of Pichia pastoris makes it a remarkable host for the heterologous expression of PETase from Ideonella sakaiensis 201-F6 (IsPETase). Taking advantage of the abundant N- and O-linked glycosylation sites in IsPETase and the efficient post-translational modification in endoplasmic reticulum, IsPETase is heavily glycosylated during secretory expression with P.

Remarkable Enhancement of Piezoelectric Performance by Heavy Halogen Substitution in Hybrid Perovskite Ferroelectrics.

Piezoelectric materials that enable electromechanical conversion have great application value in actuators, transducers, sensors, and energy harvesters. Large piezoelectric () and piezoelectric voltage () coefficients are highly desired and critical to their practical applications. However, obtaining a material with simultaneously large and has long been a huge challenge.

Genome sequence and comparative analysis of fungal antagonistic strain Bacillus velezensis LJBV19.

Bacillus species as fungal antagonistic agents have been widely used in the agriculture and considered as safe products for the management of plant pathogens. In this study, we reported the whole genome sequence of strain LJBV19 isolated from grapevine rhizosphere soil. Strain LJBV19 was identified as Bacillus velezensis through morphological, physicochemical, molecular analysis and genome comparison.

CircFAT1 Promotes Lung Adenocarcinoma Progression by Sequestering miR-7 from Repressing IRS2-ERK-mediated CCND1 Expression.

Our understanding of coding gene functions in lung cancer leads to the development of multiple generations of targeted drugs. Noncoding RNAs, including circular RNAs (circRNAs), have been demonstrated to play a vital role in tumorigenesis. Uncovering the functions of circRNAs in tumorigenesis and their underlying regulatory mechanisms may shed new light on the development of novel diagnostic and therapeutic strategies for human cancer.

ILP-2: A New Bane and Therapeutic Target for Human Cancers.

Inhibitor of apoptosis protein-related-like protein-2 (ILP-2), also known as BIRC-8, is a member of the inhibitor of apoptosis protein (IAPs) family, which mainly encodes the negative regulator of apoptosis. It is selectively overexpressed in a variety of human tumors and can help tumor cells evade apoptosis, promote tumor cell growth, increase tumor cell aggressiveness, and appears to be involved in tumor cell resistance to chemotherapeutic drugs. Several studies have shown that downregulation of ILP-2 expression increases apoptosis, inhibits metastasis, reduces cell growth potential, and sensitizes tumor cells to chemotherapeutic drugs.

An unprecedented azobenzene-based organic single-component ferroelectric.

Organic single-component ferroelectrics, as an important class of metal-free ferroelectrics, are highly desirable because of their easy processing, mechanical flexibility, and biocompatibility. However, although nearly 50 years have passed since the discovery of photochromism in azobenzene-doped cholesteric liquid crystals, ferroelectricity has never been found in azobenzene-based crystals. Here, we use an amino group to substitute a fluorine atom of 2,2',4,4',6,6'-hexafluoroazobenzene, which successfully introduces ferroelectricity into 2-amino-2',4,4',6,6'-pentafluoroazobenzene (APFA).

Nonlinear Predictive Motion Control for Autonomous Mobile Robots Considering Active Fault-Tolerant Control and Regenerative Braking.

To further advance the performance and safety of autonomous mobile robots (AMRs), an integrated chassis control framework is proposed. In the longitudinal motion control module, a velocity-tracking controller was designed with the integrated feedforward and feedback control algorithm. Besides, the nonlinear model predictive control (NMPC) method was applied to the four-wheel steering (4WS) path-tracking controller design.