Molecular and Biological Characterization of an Isolate of Fusarium graminearum dsRNA mycovirus 4 (FgV4) from a New Host .

Wheat Fusarium crown rot (FCR), mainly caused by , is one of the most important diseases. Some mycoviruses are reported to have a hypovirulence trait and considered as a biocontrol agent for plant fungal diseases. In most cases, mycovirus biological effects have not been explored clearly.

Addition of anti-PD-1 immunotherapy to BRAF inhibitor-based targeted therapy improves real-world survival and delays brain metastases in patients with BRAF-mutant advanced melanoma: a multicenter cohort study.

Anti-PD-1 immunotherapy and targeted therapy (TT) represent two major therapeutic modalities for BRAF-mutant advanced melanoma, but the efficacy of combination therapy in Asian populations remains unknown. Asian melanoma patients differ significantly from Caucasians in tissue subtypes, pathogenesis and response to treatment. We retrospectively analyzed data of BRAF-mutant advanced melanoma patients treated with first-line vemurafenib (V) ± anti-PD-1 or dabrafenib+trametinib (D+T) ± anti-PD-1 between 2014 and 2023 from three centers in China.

Pickering Emulsions Stabilized by a Naturally Derived One-Dimensional All-In-One Hybrid Nanostructure.

Colloidal particles generated from plant-derived proteins and polysaccharides have high potential as particulate stabilizers since they are environmentally friendly, biocompatible, and biodegradable. It has also been shown that amphiphilic anisotropic particles are more effective particulate stabilizers at the oil/water interface. In this study, a one-dimensional all-in-one zein nanoparticle/cellulose nanofiber hybrid nanostructure (ZCHN) was successfully prepared by self-assembling hydrophilic cellulose nanofibers (CNFs) and hydrophobic zein nanoparticles (ZNPs).

Dynamic Assembly of Microgels and Polymers at Non-Aqueous Liquid/Liquid Interfaces.

Particle assembly at liquid-liquid interfaces presents a promising bottom-up strategy for creating supramolecular materials with advanced functionalities. However, the significantly lower interfacial tension observed in immiscible organic phases compared to traditional oil-water systems has hindered the effective adsorption and assembly of particles at oil-oil interfaces. In this work, a versatile and effective strategy is presented that utilizes the assembly and jamming of microgels and polymer ligands at non-aqueous liquid-liquid interfaces to create non-aqueous Pickering emulsions and reconfigurable droplet networks.

Unveiling the rheological behavior of poly(styrene-co-N-isopropylacrylamide) microgel aqueous suspensions.

Poly(N-isopropylacrylamide)-based microgels are soft and deformable colloids, which can swell and shrink in response to external stimuli such as temperature or pH, making them suitable for various industries. Herein, poly(styrene-co-N-isopropylacrylamide) microgels with varying softness were synthesized through the doping of different proportions of styrene into their network structure. Rheological tests revealed that the deformability, surface charge, and wettability of microgels were precisely regulated through adjustments to styrene doping levels.

Endothelial STING-JAK1 interaction promotes tumor vasculature normalization and antitumor immunity.

Stimulator of interferon genes (STING) agonists have been developed and tested in clinical trials for their antitumor activity. However, the specific cell population(s) responsible for such STING activation-induced antitumor immunity have not been completely understood. In this study, we demonstrated that endothelial STING expression was critical for STING agonist-induced antitumor activity.

Isolation and identification of six newly recorded wheat Fusarium crown rot associated species.

Fusarium crown rot (FCR) has become one of the most serious diseases affecting wheat production worldwide. To date, many Fusarium species associated with wheat FCR disease have been reported. To gain a deeper understanding of Fusarium species diversity associated with wheat FCR, extensive research was conducted to identify different Fusarium species.

Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib-Resistant Non-Small Cell Lung Cancer.

Non-small cell lung cancers (NSCLC) frequently acquire resistance to tyrosine kinase inhibitors (TKI) due to epidermal growth factor receptor (EGFR) mutation or activation of the bypass pathway involving mesenchymal-epithelial transition factor (Met). To address this challenge, a bispecific nanobody-aptamer chimera is designed to target mutated EGFR and Met simultaneously to block their cross-talk in NSCLC. The EGFR-Met chimera is cost-effectively engineered using microbial transglutaminase and click chemistry strategies.

New strategy of LI-RADS v2018 to improve the sensitivity for small hepatocellular carcinoma ≤ 3.0 cm on extracellular-contrast enhanced MRI.

Introduction: We aimed to modify LI-RADS version 2018 to improve sensitivity and determine the value of the combination of high alpha-fetoprotein (AFP) levels for small HCC (sHCC, ≤ 30 mm) diagnosis.

Methods: A total of 984 patients at high risk for HCC, with 1204 observations (including 997 small observations ≤ 30 mm), who underwent extracellular contrast-enhanced MRI were enrolled from five independent centers. Blinded readers evaluated the LI-RADS features and categorized each observation according to the LI-RADS v2018, modified LI-RADS and EASL.

The association between weight-adjusted waist index and sleep disorders in U.S. adults: results from NHANES 2005-2008.

The detrimental effects of obesity on sleep disorders have garnered a lot of interest. The weight-adjusted waist index (WWI) is a newly developed anthropometric index calculated in terms of weight and waist circumference. The body mass index has been employed to evaluate obesity in the majority of studies that connect obesity to sleep disorders.

Relationships between Wheat Development, Soil Properties, and Rhizosphere Mycobiota.

Wheat is a vital global food crop, yet it faces challenges in saline-alkali soils where Fusarium crown rot significantly impacts growth. Variations in wheat growth across regions are often attributed to uneven terrain. To explore these disparities, we examined well-growing and poorly growing wheat samples and their rhizosphere soils.

Analysis of risk factors for liver metastasis in patients with gastric cancer and construction of prediction model: A multicenter study.

Background: To retrospectively analyze the risk factors of liver metastases in patients with gastric cancer in a single center, and to establish a Nomogram prediction model to predict the occurrence of liver metastases.

Methods: A total of 96 patients with gastric cancer who were also diagnosed with liver metastasis (GCLM) and treated in our center from January 1, 2010 to December 31, 2020 were included. The clinical data of 1095 patients with gastric cancer who were diagnosed without liver metastases (GC) in our hospital from January 1, 2014 to December 31, 2017 were retrospectively compared by univariate and multivariate logistic regression.

The Multi-Functional Third Acceptor Realizes the Synergistic Improvement in Photovoltaic Parameters and the High-Ratio Tolerance of Ternary Organic Photovoltaics.

The ternary strategy proves effective for breakthroughs in organic photovoltaics (OPVs). Elevating three photovoltaic parameters synergistically, especially the proportion-insensitive third component, is crucial for efficient ternary devices. This work introduces a molecular design strategy by comprehensively analyzing asymmetric end groups, side-chain engineering, and halogenation to explore the outstanding optoelectronic properties of the proportion-insensitive third component in efficient ternary systems.

Facile Preparation of Silica/Tannic Acid/Zein Microcapsules Templated from Non-Aqueous Pickering Emulsions and their Application in Cargo Protection.

Microcapsules have attracted significant attention in academia and industry due to their unique properties for protecting and controlling the release of active substances. However, based on water-insoluble biopolymers, developing a straightforward approach to prepare microcapsules with improved biocompatibility and functional shells remains a great challenge. In this study, zein, a water-insoluble protein, is employed to prepare robust microcapsules facilely using oil-in-aqueous ethanol Pickering emulsions as templates.

Alterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients.

Background: Patients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared to healthy individuals. However, knowledge regarding the bile microbiome and its potential impact on progression-free survival in PDACs remains limited.

Methods: Patients with PDAC (n = 45), including 20 matched pairs before and after surgery, and benign controls (n = 16) were included prospectively.

Histone H3 N-Terminal Lysine Acetylation Governs Fungal Growth, Conidiation, and Pathogenicity through Regulating Gene Expression in .

The acetylation of histone lysine residues regulates multiple life processes, including growth, conidiation, and pathogenicity in filamentous pathogenic fungi. However, the specific function of each lysine residue at the N-terminus of histone H3 in phytopathogenic fungi remains unclear. In this study, we mutated the N-terminal lysine residues of histone H3 in , the main causal agent of Fusarium crown rot of wheat in China, which also produces deoxynivalenol (DON) toxins harmful to humans and animals.

One-Step Formation of Pickering Double Emulsion Costabilized by Hydrophobic Silica Nanoparticles and Sodium Alginate.

Pickering double emulsions exhibit higher stability and biocompatibility compared with surfactant-stabilized double emulsions. However, tailored synthesis of particle stabilizers with appropriate wettability is time consuming and complicated and usually limits their large-scale adoption. Using binary stabilizers may be a simple and scalable strategy for Pickering double emulsion formation.

Urchin-Like Mesoporous TiN Hollow Sphere Enabling Promoted Electrochemical Kinetics of Bromine-Based Flow Batteries.

Bromine-based flow batteries (BFB) have always suffered from poor kinetics due to the sluggish Br /Br redox, hindering their practical applications. Developing cathode materials with high catalytic activity is critical to address this challenge. Herein, the in-depth investigation for the free energy of the bromine redox electrode is conducted initially through DFT calculations, establishing the posterior desorption during oxidation as the rate-determining step.