Publications by authors named "Hang Han"

Objective: This study aims to evaluate the current state of family function and self-management abilities in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and analyze the correlation between the two.

Methods: Baseline data were collected from 243 patients with MASLD, utilizing the Family Care Index and Self-Management Scale. Multiple linear regression analysis was employed to assess factors influencing self-management in these patients.

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Psoriasis is a chronic inflammatory skin condition characterized by erythematous plaques with white scales. Its pathogenesis is closely linked to oxidative stress and an imbalance in Th1/Th2 immune responses. Current treatments for psoriasis, such as topical agents, systemic therapies and phototherapy, frequently fail to achieve complete remission in clinical settings.

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Anthrax is an acute infectious disease caused by Bacillus anthracis, which can infect various animals and humans. Cutaneous anthrax primarily presents as infiltrative, edematous erythema, surface vesicles, hemorrhagic vesicles, and necrotic eschar; some patients may also experience systemic symptoms such as fever and leukocytosis. With economic development and improvements in public health conditions, naturally occurring cases of cutaneous anthrax have significantly decreased, leading to limited reports on the pathological manifestations of this disease.

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Article Synopsis
  • Valproic acid (VPA), an antiepileptic drug, may negatively affect male fertility, though the exact reasons for these effects remain unclear.
  • A systematic review and meta-analysis analyzed preclinical (animal) and clinical (human) studies to evaluate how VPA impacts male reproductive factors, including sperm count and quality.
  • Results showed significant reductions in sperm count and motility in animal studies, an increase in abnormal sperm, and inconclusive findings in human studies regarding sperm count.
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Human-machine interactions (HMIs) have penetrated into various academic and industrial fields, such as robotics, virtual reality, and wearable electronics. However, the practical application of most human-machine interfaces faces notable obstacles due to their complex structure and materials, high power consumption, limited effective skin adhesion, and high cost. Herein, we report a self-powered, skin adhesive, and flexible human-machine interface based on a triboelectric nanogenerator (SSFHMI).

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Inflammatory diseases, including psoriasis, atherosclerosis, rheumatoid arthritis, and ulcerative colitis, are characterized by persistent inflammation. Moreover, the existing treatments for inflammatory diseases only provide temporary relief by controlling symptoms, and treatments of unstable and expensive. Therefore, new therapeutic solutions are urgently needed to address the underlying causes or symptoms of inflammatory diseases.

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Background: Polystyrene nanoplastics (PS-NPs), are ubiquitous pollution sources in human environments, posing significant biosafety and health risks. While recent studies, including our own, have illustrated that PS-NPs can breach the blood-testis barrier and impact germ cells, there remains a gap in understanding their effects on specific spermatogenic cells such as spermatocytes.

Methods And Results: Herein, we employed an integrated approach encompassing phenotype, metabolomics, and transcriptomics analyses to assess the molecular impact of PS-NPs on mouse spermatocyte-derived GC-2spd(ts) cells.

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Microplastics (MPs) and nanoplastics (NPs) have become hazardous materials due to the massive amount of plastic waste and disposable masks, but their specific health effects remain uncertain. In this study, fluorescence-labeled polystyrene NPs (PS-NPs) were injected into the circulatory systems of mice to determine the distribution and potential toxic effects of NPs in vivo. Interestingly, whole-body imaging found that PS-NPs accumulated in the testes of mice.

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The process of mining activities often causes the formation of acid mine drainage (AMD). Through rock fractures and underground rivers, AMD can easily enter the groundwater environment near mines and cause serious pollution to water quality. In order to effectively evaluate the quality of polluted mine water and to understand its threat to the ecosystem around the mine.

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Some major challenges of ovarian tissue vitrification and transplantation include follicle apoptosis induced by cryopreservation and ischemia-reperfusion injury, as well as ovarian follicle loss during post-transplantation. This research aimed to investigate the protective effects and underlying mechanisms of follicle-stimulating hormone (FSH) and Sphingosine-1-phosphate (S1P) on vitrified and post-transplantation ovaries. Ovaries from 21-day-old mice were cryopreservation by vitrification with 0.

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The self-healing of glassy polymer materials on site has always been a huge challenge due to their frozen polymer network. We herein report self-repairable glassy luminescent film by assembling a lanthanide-containing polymer with randomly hyperbranched polymers possessing multiple hydrogen (H) bonds. Because of multiple H bonds, the hybrid film exhibits enhanced mechanical strength, with high glass transition temperature () of 40.

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Microplastics (MPs) and nanoplastics (NPs) are novel environmental pollutants that are ubiquitous in the environment and everyday life. NPs can easily enter the tissues and have more significant potential health risks due to their smaller diameter. Previous studies have shown that NPs can induce male reproductive toxicity, but the detailed mechanisms remain uncertain.

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The development of repairable MOF-polymer hybrid materials will greatly extend their service life by repairing fractured parts on the spot; however, it is difficult for robust glassy polymers to self-heal below the glass transition temperature () as the polymer network is frozen. We herein report glassy polyMOF-RHP hybrid membranes by integrating lanthanide polyMOF (polyLnMOF) with randomly hyperbranched polymers (RHP) bearing a high density of hydrogen bonds. Since crystalline lanthanide MOFs act as multiconnected cross-linking agents and cross-link the interpenetrating polymer network, the obtained polyLnMOF-polymer membrane shows enhanced mechanical strength with a storage modulus of 3.

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Chinese hamster ovary (CHO) cells represent a group of predominantly used mammalian hosts for producing recombinant therapeutic proteins. Known for their rapid proliferation rates, CHO cells undergo aerobic glycolysis that is characterized by fast glucose consumption, that ultimately gives rise to a group of small-molecule organic acids. However, only the function of lactate has been extensively studied in CHO cell culture.

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Ammopiptanthus mongolicus is the only evergreen broad-leaved shrub present in arid areas of Northwest China and plays an important role in maintaining the stability of the local desert ecosystem. It can survive under extreme temperatures (e.g.

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Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women. polysaccharide (LBP) is an extract from the fruits of the traditional Chinese herb, . LBP is a promising anticancer drug, due to its high activity and low toxicity.

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Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by a variety of clinical features, including anovulation, hyperandrogenism, and ovarian abnormalities, resulting in infertility. PCOS affects approximately 6%-15% of all reproductive-age women worldwide. Metformin, a popular drug used to treat PCOS in patients, has beneficial effects in reducing hyperandrogenism and inducing ovulation; however, the mechanisms by which metformin ameliorates PCOS are not clear.

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The survival and performance of urban forests are increasingly challenged by urban drought, consequently compromising the sustainability and functionality of urban vegetation. Plant-water relations largely determine species drought tolerance, yet little is known about the hydraulics of urban forest species. Here, we report the leaf hydraulic and carbon traits that govern plant growth and drought resistance, including vulnerability to embolism, hydraulic conductivity and leaf gas exchange characteristics, as well as morphological traits that are potentially linked with these physiological attributes, with the aim of guiding species selection and management in urban forests.

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B cell lymphoma 2 () is an important antiapoptotic gene that plays a dual role in the maintenance of the dynamic balance between the survival and death of cancer cells. In our previous study, Bcl-2 was shown to delay the G0/G1 to S phase entry by regulating the mitochondrial metabolic pathways to produce lower levels of adenosine triphosphate (ATP) and reactive oxygen species (ROS). However, the detailed molecular mechanisms or pathways by which Bcl-2 regulates the cell cycle remain unknown.

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To our knowledge, this was the first study in which caffeic acid (CA) was successfully evaluated as a matrix to enhance the detection and imaging of endogenous proteins in three biological tissue sections (, a rat brain and and germinating soybean seeds) by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). Our results show several properties of CA, including strong ultraviolet absorption, a super-wide MS detection mass range close to 200,000 Da, micrometer-sized matrix crystals, uniform matrix deposition, and high ionization efficiency. More high-molecular-weight (HMW) protein ion signals (/ > 30,000) could be clearly detected in biological tissues with the use of CA, compared to two commonly used MALDI matrices, , sinapinic acid (SA) and ferulic acid (FA).

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Herein, we report a metal-free intramolecular carbofluorination protocol for the synthesis of tetrasubstituted monofluoroalkenes from internal -ynones and Selectfluor with both high stereoselectivity and broad functional group tolerance. The chelation between tetrafluoroborate anion and the oxygen present in the aldehyde group rendered the reaction highly stereoselective, with the tetrafluoroborate serving as the direct fluorine source. Therefore, with addition of sodium tetrafluoroborate, Selectfluor could be reused several times without sacrificing reactivity.

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Di-(2-ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers, and it is widely applied in various plastic products. DEHP is an endocrine-disrupting chemical (EDC) that has been shown to disrupt the function of reproductive system in females. Although many studies have shown that DEHP potentially causes female reproductive toxicity, including depletion of the primordial follicle and decreased sex hormone production, the specific mechanisms by which DEHP affects female reproduction remain unknown.

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Article Synopsis
  • Pogonatherum crinitum (P. crinitum) shows potential as a lead (Pb) hyperaccumulator, but the impact of Pb on its rhizosphere soil’s enzymes and microbial composition is not well understood.
  • An indoor experiment exposed P. crinitum seedlings to various concentrations of Pb to measure enzymatic activity (protease, urease, acid phosphatase, invertase) and analyze soil bacteria through 16 S rDNA sequencing.
  • Results demonstrated that higher Pb levels increased acid phosphatase and influenced bacterial composition, with certain bacterial groups thriving under specific Pb concentrations, indicating a complex interaction between Pb contamination and soil microbial health that could aid P. crinitum's growth.
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The niobium nitride (NbN) nanowires fabricated with the high-quality ultra-thin NbN film with a thickness of 3 nm-6 nm were widely used for single photon detectors. These nanowires had a low aspect ratio, less than 1:20. However, increasing the thickness and the aspect ratio of highly-uniformed NbN nanowires without reducing the superconductivity is crucial for the device in detecting high-energy photons.

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