Publications by authors named "Hang Fan"

Coenzyme Q (CoQ) is essential for energy production by mitochondrial respiration, and it is a supplement most often used to promote cardiovascular health. Humans make CoQ, but cereals and some vegetable/fruit crops synthesize CoQ with a side chain of nine isoprene units. Engineering CoQ production in crops would benefit human health, but this is hindered by the fact that the specific residues of the enzyme Coq1 that control chain length are unknown.

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Hydrogen embrittlement is a critical issue for zirconium alloys, which receives long-term attention in their applications. The formation of brittle hydrides facilitates crack initiation and propagation, thereby significantly reducing the material's ductility. This study investigates the tensile properties and hydride morphology of a novel zirconium alloy under different hydrogen-charging current densities ranging from 0 to 300 mA/cm, aiming to clarify the influence of hydrides on the fracture behavior of the alloy.

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Due to the remoteness of rural areas, the impact of environmental pollution on residents' health has not received adequate attention. This study examined the relationship between coal consumption and residents' health status in rural areas in China between 2005 and 2021. We explored the impact of air pollution caused by coal combustion on the health of rural residents in China and provided associated countermeasures.

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Background: Central lymph node metastasis (CLNM) in papillary thyroid cancer (PTC) significantly influences surgical decision-making strategies.

Objectives: This study aims to develop a predictive model for CLNM in PTC patients using magnetic resonance imaging (MRI) and clinicopathological data.

Methods: By incorporating deep learning (DL) algorithms, the model seeks to address the challenges in diagnosing CLNM and reduce overtreatment.

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are endosymbiotic bacteria that infect a wide range of arthropods and filarial nematodes, often manipulating host reproduction. The efficacy of -based interventions for dengue and chikungunya control has been validated through numerous field studies in recent years. This study aimed to investigate the diversity and prevalence of infections in sylvatic mosquitoes from two locations in Recife, Brazil.

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  • Plague, caused by Yersinia pestis, has increased in Inner Mongolia since 2000, responsible for 80% of China's cases in the last five years.
  • A study of 585 Y. pestis strains from 1948 to 2021 identified three main lineages, with the 2.MED3 lineage being the most common, along with seven sub-phylogroups displaying different transmission patterns.
  • The Xilingol League region serves as a crucial reservoir for the plague bacterium, showing varied transmission dynamics that improve the understanding of its epidemiology and aid in control measures.
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With the increasing demand for clean energy sources, the need for large-scale energy storage systems to ensure the stable output of renewable energy sources, such as wind and solar, has also increased. Sodium-ion batteries have emerged as a potential solution for these storage systems owing to their high energy density, abundance in the Earth's crust, and low cost. However, the larger atomic radius of sodium ions results in higher energy barriers for ion migration in cathode materials, which can affect the cycle life and rate performance of the battery.

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Objectives: This study investigated the effectiveness of a deep convolutional neural network (CNN) in diagnosing and staging caries lesions in quantitative light-induced fluorescence (QLF) images taken by a self-manufactured handheld device.

Methods: A small toothbrush-like device consisting of a 400 nm UV light-emitting lamp with a 470 nm filter was manufactured for intraoral imaging. A total of 133 cases with 9,478 QLF images of teeth were included for caries lesion evaluation using a CNN model.

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  • SARS-CoV-2 variants, including Alpha, Beta, and Delta, are still emerging and competing for dominance in various cell types, revealing distinct competitive advantages depending on the environment.
  • The study demonstrated that the Beta variant thrived in Caco-2 cells, while the wild type and Alpha were more fit in Vero E6 cells; high neutralizing antibody levels altered these fitness dynamics.
  • Researchers also discovered that homologous recombination occurred among variants during experiments, particularly in a specific genomic region, showing how immune pressure impacts the genetic evolution of SARS-CoV-2.
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Cardiac fibrosis is a pathological response characterized by excessive deposition of fibrous connective tissue within the heart. It typically occurs following cardiac injuries or diseases. However, the lack of suitable models for disease modeling and high-throughput drug discovery has hindered the establishment of an effective treatments for cardiac fibrosis.

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Excessive swelling is one important factor that leads to high fuel permeability and limited operating concentration of methanol for proton exchange membranes. Herein, a collaborative strategy of main-chain and molecular-network engineering is applied to lower swelling ratio and improve methanol resistance for highly sulfonated polyimide. Two m-phenylenediamine monomers (4-(2,3,5,6-tetrafluoro-4-vinylphenoxy)benzene-1,3-diamine and 4,6-bis(2,3,5,6-tetrafluoro-4-vinylphenoxy)benzene-1,3-diamine) with tetrafluorostyrol groups are designed and synthesized.

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  • Existing treatments for autoimmune diseases are often ineffective and have serious side effects, which complicates targeted treatment.
  • Researchers have created multifunctional fusion nanovesicles using grapefruit-derived exosomes and engineered stem cell membranes to effectively deliver an immunosuppressant drug called CX5461 directly to inflamed tissue.
  • The new nanovesicles, FV@CX5461, show great promise in treating skin conditions like psoriasis and atopic dermatitis by reducing inflammation and restoring immune balance.
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  • Plague is an illness caused by a germ called Yersinia pestis, and it can come back after being quiet for a long time.
  • Scientists studied 356 samples of this germ from China to learn how it changed and spread over time.
  • They found two different groups of the germ that caused separate outbreaks, showing that the second outbreak wasn’t related to the first one, which helps us understand and prevent future plagues.
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Plague, one of the most devastating infectious diseases in human history, is caused by the bacterium Yersinia pestis. Since the 1950s, the Dehong Dai-Jingpo Autonomous Prefecture (DH) in Yunnan Province, China, has recorded plague outbreaks that have resulted in 1,153 human cases and 379 deaths. The genetic diversity and transmission characteristics of Y.

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  • Future self-continuity can help prevent depression in college students.
  • Two studies in China examined how this works, including the importance of feeling life has meaning and having support from others.
  • The results showed that thinking positively about the future can reduce depression, and having support from friends and family is important as well.
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The seasonal human coronaviruses (HCoVs) have zoonotic origins, repeated infections, and global transmission. The objectives of this study are to elaborate the epidemiological and evolutionary characteristics of HCoVs from patients with acute respiratory illness. We conducted a multicenter surveillance at 36 sentinel hospitals of Beijing Metropolis, China, during 2016-2019.

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Introduction: Based on the ecological systems theory and cumulative risk model, the current study aimed to determine the mediating effects of parenting styles, peer relationship, and psychological capital on family socioeconomic status and adolescents' aggressive behaviors, as well as the moderating effects of economic regional differences.

Methods: In a cross-sectional design, 1271 Chinese adolescents were recruited to complete the MacArthur Scale, the short-form Egna Minnen av Barndoms Uppfostran, the Positive PsyCap Questionnaire, the peer support subscale in the Student Personal Perception of Classroom Climate, and the Aggression Questionnaire.

Results: After controlling for gender and age, parenting style, peer relationship, and psychological capital not only mediated, but also constituted multiple chains mediation between family socioeconomic status and aggressive behaviors.

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  • A four-year-old boy experienced recurrent fever and severe pneumonia due to a reassortant avian influenza A-H3N8 virus, identified through high-throughput sequencing.
  • The virus displayed avian gene characteristics and internal genes from H9N2 strains, suggesting increased virulence and ability to infect mammals, with the child suffering from multiple organ dysfunction and requiring intensive medical support.
  • Although H3N8 RNA was found in pets and the environment around the boy, there were no signs of illness in family members, indicating that person-to-person transmission is unlikely, highlighting the need for ongoing monitoring of avian influenza threats.
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  • Sage is a plant that comes from the Mediterranean and is both useful for medicine and looks nice in gardens.
  • Scientists studied the sage's DNA and found special genes that help produce important substances in its roots and shoots.
  • The research shows how different types of sage have changed over time and how they create different chemicals depending on their growth forms.
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tRNA-derived small RNAs (also known as tsRNAs) are novel kinds of non-coding RNAs. Although tsRNAs are aberrantly expressed in different tumor types, there is scanty of research investigating their expression profiling and functions in pulmonary adenocarcinoma (PADC). We identified the expression of AS-tDR-007872 in 30 non-small-cell lung carcinoma (NSCLC) patients' carcinoma tissues and conducted biological function evaluation.

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Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne bunyavirus, causes mild-to-moderate infection to critical illness or even death in human patients. The effect of virus variations on virulence and related clinical significance is unclear. We prospectively recruited SFTSV-infected patients in a hotspot region of SFTS endemic in China from 2011 to 2020, sequenced whole genome of SFTSV, and assessed the association of virus genomic variants with clinical data, viremia, and inflammatory response.

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  • In September 2019, many children in Shenzhen and Dongguan, China, got sick with gastroenteritis after eating egg sandwiches at a nursery.
  • Health experts quickly teamed up to find out where the sickness came from, using fast lab tests and genetic analysis to trace the source.
  • They discovered that the sickness was caused by a type of bacteria found in the sandwiches, and they realized it was not from the local area, meaning it likely came from further away through the egg supply chain.
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  • Respiratory syncytial virus (RSV) is an RNA virus that primarily causes severe respiratory illness in children under two, as well as affecting infants and the elderly globally.
  • RSV circulates only among humans but was first isolated from chimpanzees; while it can infect some lab animals, it doesn’t naturally spread in them.
  • Research discovered that Malayan pangolins have RSV strains closely related to human strains, indicating the possibility of human-to-wildlife transmission of the virus.
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Ethnopharmacological Relevance: Aconitine, a C-norditerpenoid alkaloid, derives from many medicinal plants such as Aconitum carmichaelii Debx. (Chinese:), Aconitum kusnezoffii Reichb (Chinese:), which were used to rheumatic fever, painful joints and some endocrinal disorders.

Aims Of The Review: The present paper reviews research progress relating to the pharmacokinetics, physiological and pathological processes of aconitine, while some promising research direction and the detoxification of aconitine are also discussed.

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