The relationship between indoor airborne culturable bacteria with passenger flow in 132 traffic stations during 2019-2020, China.

This study aims to provide technical support for the development of a rational administration strategy for indoor environment and passenger flow of stations. The analysis was conducted monitor data of long distance bus stations and train/high speed railway stations from the National project. The monitor and surveyed data included indoor airborne culturable bacteria (IAB), passenger flow, area and height of stations.

Distinct pathway activities are associated with prognosis and response to bortezomib-containing treatment in MCL1-M based molecular subtypes of multiple myeloma.

Multiple myeloma (MM) is the second most prevalent hematological malignancy and remains incurable with remarkable heterogeneity in prognosis and treatment response across the patients. Clinical diagnosis and the existing molecular classification systems are inadequate for predicting treatment responses. Based on the convergence between plasma cell development and MM pathogenesis, we identified a gene co-expression module centered on the plasma cell survival regulator MCL1 (MCL1 module, MCL1-M) in the transcriptomes of pre-treated MM, which enabled stratification of MM patients into MCL1-M high and MCL1-M low molecular subtypes with subtype-specific prognosis and response to bortezomib-containing treatment.

Associations of multiple blood metals with cardiac structure and function: A cross-sectional study in a CAD population.

Coronary artery disease (CAD) is often accompanied by abnormal cardiac structure and function, leading to an increased prognostic risk. However, less is known about the associations of mixed metals with abnormal cardiac structure and function in CAD patients. Here, we aimed to investigate the associations of exposure to metal mixtures with cardiac structure and function and potential interactions in a CAD population.

Globally Guided Deep V-Network-Based Motion Planning Algorithm for Fixed-Wing Unmanned Aerial Vehicles.

Fixed-wing UAVs have shown great potential in both military and civilian applications. However, achieving safe and collision-free flight in complex obstacle environments is still a challenging problem. This paper proposed a hierarchical two-layer fixed-wing UAV motion planning algorithm based on a global planner and a local reinforcement learning (RL) planner in the presence of static obstacles and other UAVs.

Unequal Health Risks and Attributable Mortality Burden of Source-Specific PM in China.

Anthropogenic emissions, originating from human activities, stand as the primary contributors to PM, which is recognized as a global health threat. The disease burden associated with PM has been extensively documented. However, the prevailing estimations have predominantly relied on PM exposure-response functions, neglecting the distinct risks posed by PM from various sources.

Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development.

Constipation is common in the diseases of the digestive system in clinics. With the change in diet structure and the increase in life pressure, the prevalence rate increases year by year. In traditional Chinese medicine (TCM), the location of the disease of constipation is in the large intestine, which is related to the dysfunction of lung, spleen, liver, kidney and other viscera.

Exposure to Concurrent Heatwaves and Ozone Pollution and Associations with Mortality Risk: A Nationwide Study in China.

Background: Concurrent extreme events are projected to occur more frequently under a changing climate. Understanding the mortality risk and burden of the concurrent heatwaves and ozone () pollution may support the formulation of adaptation strategies and early warning systems for concurrent events in the context of climate change.

Objectives: We aimed to estimate the mortality risk and excess deaths of concurrent heatwaves and pollution across 250 counties in China.

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine.

Background: Knee osteoarthritis (KOA) characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults. The pathophysiology of KOA remains poorly understood, as it involves complex mechanisms that result in the same outcome. Consequently, researchers are interested in studying KOA and require appropriate animal models for basic research.

Precisional detection of lymph node metastasis using tFCM in colorectal cancer.

The detection of colorectal cancer (CRC) lymph node (LN) metastases significantly influences treatment choices, yet identifying them in samples is time-consuming and error-prone. To enhance efficiency, we have established a LN metastasis detection method utilizing triple-parameter flow cytometry (tFCM) and have conducted a comparative assessment of its accuracy and cost-effectiveness in contrast to conventional pathological examinations. This technique utilized biomarkers cytokeratin 20 (CK20), epithelial cell adhesion molecules (EpCAM), and Pan-CK.

Association of multiple blood metals and systemic atherosclerosis: A cross-sectional study in the CAD population.

Background: Coronary atherosclerotic disease (CAD) is often accompanied by peripheral atherosclerosis, resulting in a higher risk of ischemia and cardiovascular death. Exposure to metals is associated with atherosclerotic plaques at specific sites. However, less is known about the effects of mixed metals on systemic atherosclerotic burden in CAD patients.

Adjuvant chemotherapy combined with immunotherapy in patients with cholangiocarcinoma after radical resection.

Background: The malignancy of cholangiocarcinoma is highly pronounced, and it exhibits a propensity for recurrence and metastasis even in the presence of standard chemotherapy. The efficacy of adjuvant chemotherapy combined with immunotherapy in patients with resected cholangiocarcinoma needs to be substantiated.

Methods: Data from 101 patients with cholangiocarcinoma treated at the Sun Yat-sen University Cancer Center between 2015 and 2020 were studied.

How to Apply Intraoperative Ultrasound when Spinal Trauma Surgery Is Performed in the Lateral Decubitus Position?

Objective: At present, intraoperative ultrasound was widely used in spinal surgery. But there have been no reports on the use of intraoperative ultrasound in lateral decubitus position spinal surgery. The authors' research objective was to describe the applications of intraoperative ultrasound in spinal trauma surgery when performed in the lateral decubitus position.

Indoor air quality of urban public transportation stations in China: Based on air quality evaluation indexes.

Indoor air quality (IAQ) of urban public transportation stations (UPTS) has adverse health impacts on the station employees and commuters. However, there is a lack of comprehensively evaluations of IAQ in waiting rooms of UPTS. Therefore, it is crucial to select appropriate air quality indexes (including fuzzy synthetic index (B), comprehensive index (P), I index, and indoor air quality index (IAQI)) to assess air quality and potential health risks.

Stress Distribution Prediction of Circular Hollow Section Tube in Flexible High-Neck Flange Joints Based on the Hybrid Machine Learning Model.

The flexible high-neck flange is connected to the circular hollow section (CHS) tube through welding, and the placement of the weld seam and corresponding stress concentration factor (SCF) are crucial determinants of the joint's fatigue performance. In this study, three hybrid models combining ant colony optimization (ACO), a genetic algorithm (GA), and grey wolf optimization (GWO) with a random forest (RF) model were developed to predict the stress distribution on the inner and outer walls of the CHS tube under different flange parameter combinations. To achieve this, an automated finite element (FE) analysis program for flexible high-neck flange joints was initially developed based on ABAQUS 2020 software.

Mortality risks from a spectrum of causes associated with sand and dust storms in China.

Sand and Dust Storms (SDS) pose considerable health risks worldwide. Previous studies only indicated risk of SDS on overall mortality. This nationwide multicenter time-series study aimed to examine SDS-associated mortality risks extensively.

Public concerns and attitudes towards autism on Chinese social media based on K-means algorithm.

To investigate the hot topics and attitudes of autism in the larger community. In this study, we analyzed and summarized experimental texts from the social media platform Zhihu using the TF-IDF algorithm and K-means clustering approach. Based on the analysis of the 1,740,826-word experimental text, we found that the popularity of autism has steadily risen over recent years.

The effect of NK cell therapy on sepsis secondary to lung cancer: A case report.

Patients with sepsis face high mortality rates and a bleak prognosis, prompting the need for advanced therapeutic interventions. A male patient diagnosed with moderately low-differentiated squamous cell carcinoma received diverse treatments, including radiotherapy, chemotherapy, immunotherapy, and targeted therapy to inhibit angiogenesis. Subsequently, he developed sepsis after comprehensive treatment, and conventional antibiotic combinations proved ineffective in combating the infection.

CXCL8 and the peritoneal metastasis of ovarian and gastric cancer.

CXCL8 is the most representative chemokine produced autocrine or paracrine by tumor cells, endothelial cells and lymphocytes. It can play a key role in normal tissues and tumors by activating PI3K-Akt, PLC, JAK-STAT, and other signaling pathways after combining with CXCR1/2. The incidence of peritoneal metastasis in ovarian and gastric cancer is extremely high.

Jingfang granules exert anti-psoriasis effect by targeting MAPK-mediated dendritic cell maturation and PPARγ-mediated keratinocytes cell cycle progression in vitro and in vivo.

Background: Jingfang granules (JFG), derived from JingFangBaiDu San (JFBDS), are a traditional herbal formulas used for the treatment of respiratory tract infections. They were initially prescribed to treat skin disease, such as psoriasis in Chinese Taiwan, but are not widely used for psoriasis treatment in mainland China because of the lack of anti-psoriasis mechanism research.

Purposes: The present study was designed to evaluate the anti-psoriasis effect of JFG and reveal the correlated mechanisms of JFG in vivo and in vitro using network pharmacology, UPLC-Q-TOF-MS technology and molecular biotechnology methods.

The Host Protein CAD Regulates the Replication of FMDV through the Function of Pyrimidines' Synthesis.

Foot-and-mouth disease virus (FMDV) is a single-stranded picornavirus that causes economically devastating disease in even-hooved animals. There has been little research on the function of host cells during FMDV infection. We aimed to shed light on key host factors associated with FMDV replication during acute infection.