Publications by authors named "Haner Direskeneli"
CT-P13 is a biosimilar version of infliximab, a monoclonal antibody. In individuals with ankylosing spondylitis (AS), CT-P13 has been shown to be effective and to have a well-tolerated safety profile. The aim of this study was to evaluate the long-term drug persistence, safety, and efficacy of infliximab biosimilar CT-P13 in patients with AS undergoing first-line (1st-line) and later (≥2nd-line) treatment in clinical practice.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
- A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
- Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
Clinical course of pediatric-onset Behçet's Disease in young adulthood.
Rheumatology (Oxford)
November 2024
Article Synopsis
- The study investigates the progression of Behçet's disease when it starts in childhood and how it affects patients in adulthood.
- Out of 112 pediatric patients, 93 were analyzed, revealing that around 52.5% had major organ involvement, primarily affecting the eyes, with some showing new complications as they transitioned into adulthood.
- The findings highlight the importance of continued monitoring for these patients, as nearly one-third experienced new symptoms or relapses post-childhood, underscoring the need for regular follow-ups to mitigate potential long-term damage.
Objectives: Pulmonary arterial involvement (PAI) is one of the most common causes of mortality in Behçet's disease (BD). In this study, we aimed to evaluate the clinical features, course, and recurrence risk factors of BD-associated PAI.
Methods: BD patients who were followed up in Marmara University BD outpatient clinic between 1990 and 2023 were included.
Article Synopsis
- The text talks about how our immune system can mistakenly attack our own body, which is called autoimmunity. It explains how scientists have learned about different types of immune responses over time.
- It introduces new ideas like "auto inflammation" to show a different way our immune system can act up against itself, beside the old ideas of autoimmunity.
- The text also mentions specific diseases, like rheumatoid arthritis and psoriasis, and explains how both parts of the immune system (innate and adaptive) work together in these conditions.
Article Synopsis
- Behçet disease (BD) presents with various symptoms, including mucocutaneous, ocular, and vascular manifestations, and this study explores the immune-related cytokines involved in these different BD types.
- Researchers analyzed serum samples from active and remission stages of BD patients, comparing them with healthy controls, to evaluate the levels of specific cytokines like interferon γ and interleukin 35.
- The findings indicate distinct immune responses for each BD phenotype, particularly showing that the IL-17 response is less pronounced in ocular BD, suggesting a need for targeted treatments based on cytokine patterns in various BD subtypes.
Objectives: We aimed to assess first degree relatives (FDRs) of BD patients for the presence of clinical symptoms and signs of BD and evaluate common femoral vein (CFV) wall thickness measurement for the diagnosis.
Methods: Patients with BD(n=129) and FDRs(n=230) of these patients were included. FDRs were questioned in terms of BD symptoms by phone.
Radiographic progression in Ankylosing spondylitis (AS) is driven by mechanical strain. A well-balanced spine provides a favorable weight distribution across the entheses. Pelvic parameters are useful in assessing the shape of the spine.
View Article and Find Full Text PDFArticle Synopsis
- Systemic lupus erythematosus (SLE) significantly increases the risk of cardiovascular disease, prompting a study to evaluate traditional cardiovascular risk factors in SLE patients worldwide between 2015 and 2020.
- The study included 3,401 SLE patients from 24 countries, predominantly women, revealing high rates of hypertension (35.6%), obesity (23.7%), and hyperlipidaemia (19.8%), with poor control of these risk factors across the board.
- Notably, patients with antiphospholipid syndrome had higher prevalence of cardiovascular risks but showed better control of blood pressure and lipid levels compared to those without, highlighting international discrepancies in risk factor management.
Post-thrombotic syndrome (PTS) is a frequent and important consequence of deep vein thrombosis (DVT) for Behcet`s disease (BD) patients. Although various clinical scales are used to diagnose PTS, Villalta scale was accepted as the standard tool to diagnose and grade the severity of PTS. Poor quality of life (Qol) in the general population was defined for patients with PTS, however, studies in BD patients with PTS is limited.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of two common immunosuppressive agents, methotrexate (MTX) and azathioprine (AZA), as first-line treatments for patients with Takayasu's arteritis (TAK), analyzing patient outcomes and safety.
- A total of 301 TAK patients from 10 centers were included; findings revealed similar remission and relapse rates between MTX and AZA, but a significantly higher rate of vascular surgery in the AZA group compared to MTX.
- The study also noted that patients on MTX were more likely to receive lower doses of glucocorticoids post-treatment compared to those on AZA, indicating different management outcomes between the
(1) : Systemic sclerosis (SSc) is a rare systemic disease, which often affects the esophagus, leading to dilation and complications such as dysphagia and reflux. Obstructive sleep apnea (OSA) is a chronic condition with recurrent episodes of upper airway collapsibility and is known to impair quality of life (QoL). The primary aim of this study was to investigate the occurrence of esophagus dilation in patients with SSc and concomitant OSA and, further, to address the impact of these conditions on QoL.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated the occurrence of spondyloarthritis (SpA) features in 350 patients with Takayasu arteritis (TAK), finding that 8.8% had additional SpA-related conditions, such as inflammatory bowel disease (IBD) or psoriasis.
- - Patients with both TAK and SpA displayed earlier onset of disease symptoms and required more aggressive biological treatments for active vasculitis compared to those with TAK alone.
- - The research highlighted the overlap between TAK and SpA, suggesting a potential link in their pathogenesis, possibly related to an MHC class I allele similar to that seen in spondyloarthritis.
Article Synopsis
- A study examined cancer rates in patients with ANCA-associated vasculitis (AAV) by comparing them to cancer risks in the Turkish population and identifying independent risk factors.
- Of the 461 AAV patients tracked, 19 developed cancer after an average follow-up of about 3.4 years, with higher cancer risks noted in older males and those with anti-PR3-ANCA positivity.
- The overall cancer risk for AAV patients was 2.1 times higher than that of the general population, highlighting the need for targeted cancer screening, especially for lung and head-neck cancers in older male patients.
Article Synopsis
- This study evaluated the effectiveness of a systemic score in predicting severe outcomes in patients with Still disease, including the risk of mortality and severe complications like macrophage activation syndrome.
- Involving 597 patients, the study found that a higher systemic score significantly correlated with life-threatening outcomes, with scores of 7 or above indicating a greater risk.
- Key components that were most predictive of severe outcomes included liver and lung involvement, emphasizing the importance of these factors in managing Still disease.
Article Synopsis
- The study investigates the wall thickness of the inferior vena cava (IVC) in patients with Behçet's disease (BD) compared to healthy controls, revealing that BD patients have significantly thicker IVC walls.
- Results showed that IVC wall thickness is associated with mucocutaneous and major organ involvement, indicating a correlation between vascular issues and BD symptoms.
- The findings suggest that venous wall inflammation in BD affects not only lower extremity veins but also larger venous structures like the IVC, pointing to a widespread vascular inflammation in this disease.
Article Synopsis
- A recent study investigated the thickness of the common femoral vein (CFV) in patients with Behçet's Disease (BD) using Doppler ultrasonography in both standing and supine positions.
- The study involved 42 BD patients and 41 healthy controls, finding that CFV thickness was significantly greater in BD patients compared to healthy individuals.
- The research concluded that Doppler US is a reliable, non-invasive method for diagnosing BD and that the patient's position does not influence the CFV wall thickness measurements.
Article Synopsis
- The study gathered data on 358 patients with polyarteritis nodosa (PAN) from nine countries, analyzing demographics, clinical features, and survival rates over 30 years.
- Findings showed common symptoms such as constitutional issues, skin lesions, joint pain, and neurological problems, with a significant relapse rate of 48.5% during an average follow-up of nearly five years.
- Survival rates for systemic PAN showed a decline over time, with important risk factors for mortality including older age, high serum creatinine levels, and involvement of the gastrointestinal system or central nervous system.
Correction: Clinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry.
Intern Emerg Med
January 2024