Publications by authors named "Hanene Dhouib"
Article Synopsis
- Organophosphates like dimethoate are harmful pesticides that can cause toxicity in humans and animals by inhibiting an important enzyme and promoting oxidative stress.
- The study focused on the reproductive toxicity of dimethoate in male rats and explored whether N-acetylcysteine could provide protective effects.
- Results showed that dimethoate reduced testosterone levels, increased oxidative damage, and impaired steroid hormone production, while N-acetylcysteine helped restore normal antioxidant levels and steroidogenesis.
The aim of the current study was to investigate the ability of dimethoate (DMT) to induce reprotoxicity in male mice. The dose (20 mg/kg/day) was given orally for 30 days. A significant decrease in sperm count, motility and viability and a significant increase of morphologically abnormal spermatozoa percent in DMT treated mice was observed.
View Article and Find Full Text PDFMalathion toxicity has been related to the inhibition of acetylcholinesterase, induction of oxidative stress, liver damage and impairment of kidney function as well as hematotoxicity. N-acetyl-l-cysteine (NAC) has been shown to possess curative effects in experimental and clinical investigations. The present study was designed to evaluate the protective effect of NAC against toxic consequences of malathion exposure in Wistar rats.
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